Clinical Outcomes for Patients With Ulcerative Colitis and Upper Extremity Deep Venous Thrombosis: An Analysis of the National Inpatient Sample

Background: There is limited data specifically for patients with upper extremity deep venous thrombosis (UEDVT) and Ulcerative Colitis. We sought to examine the national inpatient sample database to describe in-hospital outcomes among those patients. Methods: Data were extracted from the National Inpatient Sample (NIS) Database for the years 2019 and 2020. The NIS was searched for hospitalizations of adult patients with UEDVT with and without a concomitant diagnosis of UC using international classification of diseases-10th revision codes. Multivariate logistic was used to adjust for confounders. The primary outcome was inpatient mortality. Secondary outcomes were hospital length of stay (LOS), and total hospital charges (TOTHCG). SPSS software was used for statistical analysis. Results: This study included 25,064 patients with UEDVT, of which 3,198 (12.7%) patients also had UC. UEDVT patients with UC had higher prevalence of anemia (16.1% Vs 15.5% P< 0.001), thyroid disease (12.6% Vs 12.3% p < 0.001), and obesity (15.5% Vs 13.5% P< 0.001). In-hospital mortality was higher among the UC cohort (9.9 % Vs 9.2% P< 0.001). Multivariate regression showed that Patients with UC and UEDVT had higher inpatient mortality (OR 1.822, CI 1.737-1.869 P< 0.001). Total hospital charges were more for UEDVT patients with UC ($191,570 vs 171,538, P< 0.001). On secondary analysis it has shown that UEDVT with UC patients have higher odds of having pulmonary embolism (OR 1.513, CI 1.428-1.601, P< 0.001), GI bleed (1.301, CI 1.298-1.345, P< 0.001), arrhythmias (OR 1.479, CI 1.439-1.521, P< 0.001) and Acute kidney injury (OR 1.317, CI 1.286-1.448, P< 0.001). Conclusions: In this nationally representative population-based retrospective cohort study, UC was associated with higher mortality and worse outcomes among UEDVT patients.