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Comparative Effectiveness Topic Center

Featured Article

Research Review
Comparing Intermittent Injectable Cabotegravir + Rilpivirine vs Daily Oral HIV Treatments: SOLAR Study Highlights
01/12/2024
Hannah Musick
In this research review, long-acting injectable regimen cabotegravir + rilpivirine (CAB+RPV LA) and daily bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) treatment regimens for patients with HIV are compared in terms of...
In this research review, long-acting injectable regimen cabotegravir + rilpivirine (CAB+RPV LA) and daily bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) treatment regimens for patients with HIV are compared in terms of...
In this research review,...
01/12/2024
First Report Managed Care
Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023

Danielle Sposato

Danielle Sposato
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021

Edan Stanley

Edan Stanley
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care
News
Secukinumab May be More Efficient for Psoriatic Arthritis
08/25/2020
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more...
08/25/2020
First Report Managed Care
News
Study Finds Comparable Short-Term Outcomes Among Psoriasis Biologics
07/20/2020
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning...
07/20/2020
First Report Managed Care
Conference Insider
Comparative Effectiveness Study Examines Safety, Efficacy of Biosimilar in Clinical Trial, Real-World Practice
07/19/2018
According to a presentation at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, results from a randomized controlled trial were compared with a real-world cohort for the safety and efficacy of a biosimilar to treat...
According to a presentation at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting, results from a randomized controlled trial were compared with a real-world cohort for the safety and efficacy of a biosimilar to treat...
According to a presentation at...
07/19/2018
First Report Managed Care
Conference Insider
Urgent TAVR Has Beneficial Outcomes Compared With Elective TAVR
05/07/2018
Recent research presented at the ACC 2018 Scientific Session found that urgent or emergent transcatheter aortic valve replacement (TAVR) has acceptable outcomes when compared with elective TAVR. 
Recent research presented at the ACC 2018 Scientific Session found that urgent or emergent transcatheter aortic valve replacement (TAVR) has acceptable outcomes when compared with elective TAVR. 
Recent research presented at the...
05/07/2018
First Report Managed Care
News Connection
TAVR Improves Quality of Life Compared With Surgery
04/04/2018
A study in Age and Ageing found that patients who receive the minimally invasive procedure transcatheter aortic valve replacement (TAVR) had improved quality of life compared with patients who underwent surgery.
A study in Age and Ageing found that patients who receive the minimally invasive procedure transcatheter aortic valve replacement (TAVR) had improved quality of life compared with patients who underwent surgery.
A study in Age and Ageing found...
04/04/2018
First Report Managed Care
Conference Insider
TAVR Does Not Significantly Reduce Mortality Compared With Surgery
01/02/2018
Data presented at the AHA 2017 Scientific Sessions found that all-cause mortality among patients undergoing transcatheter aortic valve replacement (TAVR) was not significantly different compared with patients undergoing surgical aortic valve...
Data presented at the AHA 2017 Scientific Sessions found that all-cause mortality among patients undergoing transcatheter aortic valve replacement (TAVR) was not significantly different compared with patients undergoing surgical aortic valve...
Data presented at the AHA 2017...
01/02/2018
First Report Managed Care
Conference Insider
Oral, Subcutaneous Insulin Demonstrate Similar Efficacy
07/31/2017
A presentation at the American Diabetes Association’s 77th Scientific Sessions showed that oral insulin achieved similar HbA1c and fasting plasma glucose levels in patients with type 2 diabetes compared with subcutaneous insulin injections.
A presentation at the American Diabetes Association’s 77th Scientific Sessions showed that oral insulin achieved similar HbA1c and fasting plasma glucose levels in patients with type 2 diabetes compared with subcutaneous insulin injections.
A presentation at the American...
07/31/2017
First Report Managed Care
News Connection
Gilead’s Bictegravir Shows Equivalent Efficacy to Tivicay in Phase 3 Trials
06/08/2017
Multiple phase 3 HIV trials suggest fixed-dose combination treatment regimens containing Gilead's investigational agent bictegravir are noninferior to those containing GlaxoSmithKline’s Tivicay.
Multiple phase 3 HIV trials suggest fixed-dose combination treatment regimens containing Gilead's investigational agent bictegravir are noninferior to those containing GlaxoSmithKline’s Tivicay.
Multiple phase 3 HIV trials...
06/08/2017
First Report Managed Care

Newsfeed

News
Secukinumab May be More Efficient for Psoriatic Arthritis
08/25/2020
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more efficient first biologic option than adalimumab to treat patients with psoriatic arthritis, according to a recent study.
Secukinumab could be a more...
08/25/2020
First Report Managed Care
News
Study Finds Comparable Short-Term Outcomes Among Psoriasis Biologics
07/20/2020
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning 11 biologic therapies for the treatment of psoriasis found comparable short-term efficacy and tolerability among most agents.
A network meta-analysis spanning...
07/20/2020
First Report Managed Care
News
Pradaxa Efficacy Comparable to Warfarin for Treating Patients with AF
08/18/2016
A recent post-hoc analysis from the RE-LY clinical trial of dabigatran (Pradaxa), found that patients with AF who received the treatment experienced the same benefits and risks relative to warfarin treatment, regardless of valvular heart...
A recent post-hoc analysis from the RE-LY clinical trial of dabigatran (Pradaxa), found that patients with AF who received the treatment experienced the same benefits and risks relative to warfarin treatment, regardless of valvular heart...
A recent post-hoc analysis from...
08/18/2016
First Report Managed Care

Literature Review

Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023

Danielle Sposato

Danielle Sposato
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021

Edan Stanley

Edan Stanley
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care
Literature Review
Promising Outcomes for SER-109: A New Approach to Managing Recurrent CDI
10/23/2023

Danielle Sposato

Danielle Sposato
Not only does SER-109 effectively treat CDI, but results show that it can even reduce recurrence. A major benefit when it comes to associated health care costs for patients.
Not only does SER-109 effectively treat CDI, but results show that it can even reduce recurrence. A major benefit when it comes to associated health care costs for patients.
Not only does SER-109...
10/23/2023
First Report Managed Care
Literature Review
Comparing IL-6 Inhibitors and Glucocorticoids in Treating PMR: SAPHYR Trial Results
10/16/2023

Danielle Sposato

Danielle Sposato
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided researchers with valuable insights into alternative treatment options for PMR due to its larger patient population. The effectiveness of sarilumab and the achieved rates of remission offer promise for enhancing...
The SAPHYR trial has provided...
10/16/2023
First Report Managed Care
Literature Review
A Look at the Impact, Prevalence of Demodex Blepharitis
12/06/2022
Edan Stanley
This article explores the incidence, prevalence, and management of Demodex Blepharitis.
This article explores the incidence, prevalence, and management of Demodex Blepharitis.
This article explores the...
12/06/2022
First Report Managed Care
Literature Review
Anti-CD38 Monoclonal Antibody for Multiple Myeloma: A Review of Clinical Trials
11/29/2022
Maria Asimopoulos
Several ongoing and upcoming clinical trials are testing the efficacy and safety of a monoclonal antibody in combination with other therapies for multiple myeloma.
Several ongoing and upcoming clinical trials are testing the efficacy and safety of a monoclonal antibody in combination with other therapies for multiple myeloma.
Several ongoing and upcoming...
11/29/2022
First Report Managed Care
Literature Review
Isatuximab Demonstrates Significant PFS Among Patients With Multiple Myeloma
09/23/2022
Edan Stanley
This literature review explores the latest progression-free survival data for a multiple myeloma therapy option.
This literature review explores the latest progression-free survival data for a multiple myeloma therapy option.
This literature review explores...
09/23/2022
First Report Managed Care
Literature Review
Bladder Cancers: What is Low-Grade Upper Tract Urothelial Carcinoma?
09/16/2022
Edan Stanley
This literature review explores key data related to the epidemiology, clinical presentation, and treatment considerations for patients with low-grade upper tract urothelial carcinoma.
This literature review explores key data related to the epidemiology, clinical presentation, and treatment considerations for patients with low-grade upper tract urothelial carcinoma.
This literature review explores...
09/16/2022
First Report Managed Care
Literature Review
Examining 177Lu-PSMA-617 as a Treatment for Metastatic Castration-resistant Prostate Cancer
09/16/2021
Jeff Craven
In this literature review, we explore the data from the phase 3 VISION trial recently presented at the 2021 virtual annual meeting of the American Society of Clinical Oncology and published in the New England Journal of Medicine, examining...
In this literature review, we explore the data from the phase 3 VISION trial recently presented at the 2021 virtual annual meeting of the American Society of Clinical Oncology and published in the New England Journal of Medicine, examining...
In this literature review, we...
09/16/2021
First Report Managed Care
Literature Review
Examining Benefits of Cannabidiol for Patients With Seizures
08/12/2021
Edan Stanley
For the purpose of this literature review, we examine the latest data presented at the American Academy of Neurology’s (AAN) 2021 Virtual Annual Meeting regarding the use of CBD for patients with seizure disorders including TSC.  
For the purpose of this literature review, we examine the latest data presented at the American Academy of Neurology’s (AAN) 2021 Virtual Annual Meeting regarding the use of CBD for patients with seizure disorders including TSC.  
For the purpose of this...
08/12/2021
First Report Managed Care
Literature Review
Examining Dry Eye Disease Flare Treatments
05/28/2021
Edan Stanley
With a newly proposed and easily applicable definition for dry eye disease, researchers believe the condition can be diagnosed with more consistency as well as inform future trials and research. 
With a newly proposed and easily applicable definition for dry eye disease, researchers believe the condition can be diagnosed with more consistency as well as inform future trials and research. 
With a newly proposed and easily...
05/28/2021
First Report Managed Care
Literature Review
Examining Lasmiditan for the Acute Treatment of Migraine Compared With Triptans
02/12/2021

Edan Stanley

Edan Stanley
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine foundation, oral and intranasal triptan therapy has proven consistently effective when used to treat migraine earlier in the attack; however, triptan therapy is not effective for all patients with migraine and cannot...
Per the American Migraine...
02/12/2021
First Report Managed Care

First Report

Dupilumab Associated With Reduced Severe Asthma Exacerbation Rates Compared to Other Biologics
Per the results of an indirect treatment comparison, researchers found that dupilumab is associated with lower severe asthma exacerbation rates than patients treated with anti-IL-5s and o...
Weekly Dose of Hemophilia Factor VIII Therapy Delivers Significant Bleed Protection
Pegloticase Benefit Enhanced When Combined With Methotrexate for Patients With Chronic Gout
HCRU Burden of Chronic vs Episodic Migraine and Effect of Early vs Late Nonoral Triptan Use
Zanubrutinib Exhibits Superior Overall Response Rate for Adult Patients With Chronic Lymphocytic Leukemia
Access to Acute Treatments for Migraine Can Reduce Costs for Employers, Health Care System
Addition of Daratumumab to a Treatment Plan for Transplant Ineligible Patients With Multiple Myeloma Proves Beneficial
Atezolizumab Demonstrates Positive Disease-free Survival Benefit Among Patients With NSCLC
Data Supports Progression-Free Survival, Overall Survival for Long-Term CLL/SLL Treatment
ICER Report Ranks Value, Clinical Effectiveness of Dupilumab and Other AD Treatments
Dupilumab Reduces Type 2 Inflammation, May Offer Clinical Benefits for Multiple Comorbid Diseases

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FRMC Volume 21, Issue 1

Current Issue

March 2024
Volume 21
Issue 1
Current Issue
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Cover Story
Navigating Work With PBMs: Negotiations, Misalignments, and Drug Costs
12/07/2023
Mary Beth Nierengarten
Ignoring the appropriate use of drugs is equally harmful when negotiating with PBMs, as it can and does result in the wrong drugs getting on a formulary with the obvious downstream effect on patient care, costs, and outcomes.
Ignoring the appropriate use of drugs is equally harmful when negotiating with PBMs, as it can and does result in the wrong drugs getting on a formulary with the obvious downstream effect on patient care, costs, and outcomes.
Ignoring the appropriate use of...
12/07/2023
First Report Managed Care
News
CMS Issues Rules on Loss Ratios for Medicare Plans
02/19/2013
02/19/2013
First Report Managed Care
News
Study Finds No Treatment-Related Adverse Events in Boys Treated With Purified FIX Concentrate
05/09/2024
Jolynn Tumolo
Purified factor IX (FIX) concentrate was effective in treating and preventing bleeding episodes in real-world pediatric patients 6 years and younger with hemophilia B, according to a study published in the Journal of Blood Medicine.
Purified factor IX (FIX) concentrate was effective in treating and preventing bleeding episodes in real-world pediatric patients 6 years and younger with hemophilia B, according to a study published in the Journal of Blood Medicine.
Purified factor IX (FIX)...
05/09/2024
First Report Managed Care
New Approaches to Treating Diverticular Disease
09/14/2012

Tim Casey

Tim Casey
San Diego—Recent research has indicated healthcare professionals should consider new approaches when treating diverticular disease, which affects the colon and has no known cause. Primarily, the disease affects older adults, however, the...
San Diego—Recent research has indicated healthcare professionals should consider new approaches when treating diverticular disease, which affects the colon and has no known cause. Primarily, the disease affects older adults, however, the...
San Diego—Recent research has...
09/14/2012
First Report Managed Care
Jennifer L. Mathieu Senior Vice President, Professional and Government Affairs at AMCP
Interview
Unlocking the Future of Managed Care Pharmacy: A Deep Dive into Federal Legislation and Regulations
05/15/2024
Jennifer L. Mathieu Senior Vice President, Professional and Government Affairs, AMCP
Learn about developments in federal legislation and regulations within the pharmacy landscape shaping the future of managed care in an interview with a session presenter from AMCP 2024.
Learn about developments in federal legislation and regulations within the pharmacy landscape shaping the future of managed care in an interview with a session presenter from AMCP 2024.
Learn about developments in...
05/15/2024
First Report Managed Care

Video Insights

Tejaswi Kompala
Videos
Personalizing Weight Loss Management With GLP-1 Agonists
04/05/2024

Featuring Tejaswi Kompala, MD, head of cardiometabolic clinical strategy, Teladoc 

Featuring Tejaswi Kompala, MD, head o...
Delve into the rising demand for anti-obesity medications, the complexities of obesity management, and the importance of personalized approaches in improving cardiometabolic health in this insightful interview.
Delve into the rising demand for anti-obesity medications, the complexities of obesity management, and the importance of personalized approaches in improving cardiometabolic health in this insightful interview.
Delve into the rising demand for...
04/05/2024
First Report Managed Care
Zaubler Headshot
Videos
Integrating Behavioral Health Services to Reduce ED Visits: Substance Use Disorder and Social Determinants of Health
03/27/2024

Featuring Tom Zaubler, MD, MPH, CMO at NeuroFlow

Featuring Tom Zaubler, MD, MPH, CMO a...
Join us for the continuation of an engaging two-part series showcasing an expert dedicated to reducing emergency department visits through the integration of behavioral health practices. Dr Zaubler will share invaluable insights into...
Join us for the continuation of an engaging two-part series showcasing an expert dedicated to reducing emergency department visits through the integration of behavioral health practices. Dr Zaubler will share invaluable insights into...
Join us for the continuation of...
03/27/2024
First Report Managed Care
Zaubler Headshot
Videos
Integrating Behavioral Health Services to Reduce ED Visits: Suicide Prevention and Preemptive Primary Care
03/25/2024

Featuring Tom Zaubler, MD, MPH, CMO at NeuroFlow

Featuring Tom Zaubler, MD, MPH, CMO a...
Come join us for the first installment of a captivating two-part series featuring an expert committed to minimizing emergency department visits through the implementation of behavioral health integrations. Dr Zaubler will offer valuable...
Come join us for the first installment of a captivating two-part series featuring an expert committed to minimizing emergency department visits through the implementation of behavioral health integrations. Dr Zaubler will offer valuable...
Come join us for the first...
03/25/2024
First Report Managed Care
Yash Prajapati
Videos
Navigating the Evolution of Digital Solutions in Health Care
02/27/2024

Featuring Yash Prajapati, consultant at ZS Associates 

Featuring Yash Prajapati, consultant ...
Join us in exploring the challenges and opportunities in the development, approval, and integration of digital therapeutic solutions with ZS Associates consultant Yash Prajapati.
Join us in exploring the challenges and opportunities in the development, approval, and integration of digital therapeutic solutions with ZS Associates consultant Yash Prajapati.
Join us in exploring the...
02/27/2024
First Report Managed Care
Mansur Shomali
Videos
Advancements and Challenges in Diabetes Management
02/27/2024

Featuring Mansur Shomali, MD, chief medical officer at Welldoc, endocrinologist at MedStar Health 

Featuring Mansur Shomali, MD, chief m...
Learn about the state of digital therapeutics for disease management such as diabetes care in terms of cost, outcomes, integration, and more with Dr Mansur Shomali, CMO at Welldoc.
Learn about the state of digital therapeutics for disease management such as diabetes care in terms of cost, outcomes, integration, and more with Dr Mansur Shomali, CMO at Welldoc.
Learn about the state of digital...
02/27/2024
First Report Managed Care
kevin cowart md
Videos
Costs and Benefits: How a New Cholesterol-Lowering Drug Compares to Others
10/24/2023

Featuring Kevin Cowart, PharmD, MPH, BCACP, CDCES

Featuring Kevin Cowart, PharmD, MPH, ...
Dr Kevin Cowart, assistant professor at the University of South Florida College of Pharmacy, discusses inclisiran, a new non-statin treatment for high cholesterol.
Dr Kevin Cowart, assistant professor at the University of South Florida College of Pharmacy, discusses inclisiran, a new non-statin treatment for high cholesterol.
Dr Kevin Cowart, assistant...
10/24/2023
First Report Managed Care
John Hennessy Headshot
Videos
Biosimilars, Explained
10/24/2023

Featuring John Hennessey, MBA

Featuring John Hennessey, MBA
In this video, John Hennessey, MBA, Valuate Health Consultancy, explains biosimilars in relation to cancer care: what they are, why they matter, and how they have and haven’t lived up to their promise.
In this video, John Hennessey, MBA, Valuate Health Consultancy, explains biosimilars in relation to cancer care: what they are, why they matter, and how they have and haven’t lived up to their promise.
In this video, John Hennessey,...
10/24/2023
First Report Managed Care
Videos
AVAHO 2023: Andrew Brunner, MD, Discusses Updates in MDS
10/20/2023

Featuring Andrew Brunner, MD

Featuring Andrew Brunner, MD
In this video, Dr Brunner reviews his recent discussion he held at the 2023 AVAHO Annual Meeting, and provides treatment updates in the treatment of MDS.
In this video, Dr Brunner reviews his recent discussion he held at the 2023 AVAHO Annual Meeting, and provides treatment updates in the treatment of MDS.
In this video, Dr Brunner...
10/20/2023
First Report Managed Care
Dr Kesty Headshot
Videos
A Dermatologist's Perspective on Demodex Blepharitis: Causes, Symptoms, and Treatment Options
10/19/2023

Featuring Katarina Kesty, MD, MBA, FAAD, Dermatologist and Medical Director at St. Petersburg Skin and Laser

Featuring Katarina Kesty, MD, MBA, FA...
Katarina Kesty, MD, MBA, FAAD, Dermatologist and Medical Director at St. Petersburg Skin and Laser, weighs in on Demodex blepharitis, a condition characterized by inflammation of the eyelid margin caused by an overpopulation of Demodex mites,...
Katarina Kesty, MD, MBA, FAAD, Dermatologist and Medical Director at St. Petersburg Skin and Laser, weighs in on Demodex blepharitis, a condition characterized by inflammation of the eyelid margin caused by an overpopulation of Demodex mites,...
Katarina Kesty, MD, MBA, FAAD,...
10/19/2023
First Report Managed Care

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