Psoriasis Accelerates Parkinson Disease Progression

Psoriasis risk is associated with Parkinson disease (PD) progression to dementia and depression, according to results from a recent study published in the Journal of the European Academy of Dermatology.

Researchers aimed to evaluate the casual role of psoriasis in PD progression in a mendelian randomization study. Summary statistics were used to conduct the study from a genome-wide association of psoriasis, age at onset, and progression of PD.

Genetically determined psoriasis risk was associated with progression to dementia (OR=1.07, 95 % CI: 0.1.03-1.1, P=.0004). Higher psoriasis risk was also associated with PD progression (OR=1.05, 95 % CI: 1.02-1.08, P=.001) and depression (OR=1.06, 95 % CI: 1.02-1.11, P=.001).

“These results suggested psoriasis accelerated overall progression of PD, and increased risk of dementia and depression of PD,” concluded the study authors. “A deeper understanding of neuroinflammation and immune response is likely to elucidate the potential pathogenesis of PD progression and identify novel therapeutic targets,” they added.

Reference
Li C, Li X, Lin J, Cui Y, Shang H. Psoriasis and progression of Parkinson's disease: a mendelian randomization study. J Eur Acad Dermatol Venereol. Published online July 23, 2022;10.1111/jdv.18459. doi:10.1111/jdv.18459