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Atypical Wounds Topic Center

Case Series
Unusual Clinical Presentations of Cutaneous Squamous Cell Involving Distal Extremities in Four Patients: The Importance of Tissue Sampling
05/03/2023
Carolyn Ziemer; Jayson Miedema; Scott Jaros; Paul Googe
The authors present four cases in which wounds originally thought to be nonhealing ulcers or cellulitis were revealed to be cancerous upon tissue sampling.
The authors present four cases in which wounds originally thought to be nonhealing ulcers or cellulitis were revealed to be cancerous upon tissue sampling.
The authors present four cases...
05/03/2023
Wounds
Unusual Wounds
The Novel Use of Cryopreserved Human Allograft in Extensive Hurley Stage III Hidradenitis Suppurativa
04/10/2023
David Matera; Lisa Jacob
The authors detail a case in which cryopreserved human allograft was successfully used as a bridge to skin grafting in a 37-year-old male with Hurley stage III hidradenitis suppurativa.
The authors detail a case in which cryopreserved human allograft was successfully used as a bridge to skin grafting in a 37-year-old male with Hurley stage III hidradenitis suppurativa.
The authors detail a case in...
04/10/2023
Wounds
Case Report
Pancreatic Panniculitis Secondary to Pancreatic Cyst With Lower Extremity Wounds as a Primary Presenting Feature: A Case Report and Literature Review
04/05/2023
Richard Simman, MD, FACS, FACCWS; Assava-Aree Chompunut; Lauren Fang; Samar Ayoub
The authors detail the cases of a 68-year-old male with pancreatic panniculitis characterized by erythematous wounds of the lower extremities and histology that included "ghost cells."
The authors detail the cases of a 68-year-old male with pancreatic panniculitis characterized by erythematous wounds of the lower extremities and histology that included "ghost cells."
The authors detail the cases of...
04/05/2023
Wounds
Case Report
Calciphylaxis and Skin Ulcers: A Diagnostic and Therapeutic Challenge
03/14/2023
Emanuela Francisco; Carlos Casimiro; Aline A. Gomes; Raquel Barros Pereira
In this case report, a 55-year-old White male was admitted with chronic necrotic ulcers on the right leg and an irregular violaceous plaque on the left leg under an initial suspicion of necrotizing fasciitis; following a diagnosis of...
In this case report, a 55-year-old White male was admitted with chronic necrotic ulcers on the right leg and an irregular violaceous plaque on the left leg under an initial suspicion of necrotizing fasciitis; following a diagnosis of...
In this case report, a...
03/14/2023
Wounds
Case Report
Platelet-rich Plasma Injection for Enterocutaneous Fistula: A Case Report
12/28/2022
Limin Bai; Gang Xu; Haijun Lin
A 52-year-old male patient diagnosed with an enterocutaneous fistula was treated with one application of platelet-rich plasma and saw fistula closure within 2 weeks.
A 52-year-old male patient diagnosed with an enterocutaneous fistula was treated with one application of platelet-rich plasma and saw fistula closure within 2 weeks.
A 52-year-old male patient...
12/28/2022
Wounds
Preview Image
Videos
Performing a Wound Biopsy to Diagnose Atypical Wounds
10/28/2022
Windy E. Cole, DPM, CWSP, FACCWS
In this video, Dr. Windy E. Cole reports the results of a case series in which 3 patients who presented with rare diseases—atypical wounds—were diagnosed via biopsy results. Data were presented at the 2022 SAWC Fall.
In this video, Dr. Windy E. Cole reports the results of a case series in which 3 patients who presented with rare diseases—atypical wounds—were diagnosed via biopsy results. Data were presented at the 2022 SAWC Fall.
In this video, Dr. Windy E. Cole...
10/28/2022
Wounds
Review
Atypical Ulcers: A Stepwise Approach for Clinicians
09/22/2022
Igor A. Altman; Maria M. Tsoukas; Melissa A. Nickles, BA; William J. Ennis; Nadera Sweiss
The authors share a stepwise approach for identifying, diagnosing, and treating atypical ulcers in this review.
The authors share a stepwise approach for identifying, diagnosing, and treating atypical ulcers in this review.
The authors share a stepwise...
09/22/2022
Wounds
Review
Understanding the Zebras of Wound Care: An Overview of Atypical Wounds
05/03/2022
Elizabeth A. Ansert, MA, DPM, MBA; Weldon Murry; Donald Cohen, DPM; Anthony Tickner, DPM, FRCPS, FACCWS, FAPWH, FAPWCA; Samuel Gorelik, DPM
This review provides a general overview of various atypical wound etiologies, clinical presentations and appearance, and current treatment protocols.
This review provides a general overview of various atypical wound etiologies, clinical presentations and appearance, and current treatment protocols.
This review provides a general...
05/03/2022
Wounds
Case Report
Atypical Ulcer Arising on Stasis Dermatitis: Achromic Melanoma
03/03/2022
Valentina Dini; Angelo D'Erme; Giulia Davini; Marco Romanelli; Barbara Loggini; Agata Janowska; Cristian Fidanzi; Giovanni Bagnoni
The authors report a very rare case of malignant melanoma in a 70-year-old female with stasis dermatitis.
The authors report a very rare case of malignant melanoma in a 70-year-old female with stasis dermatitis.
The authors report a very rare...
03/03/2022
Wounds

From the Publications

Case Series
Unusual Clinical Presentations of Cutaneous Squamous Cell Involving Distal Extremities in Four Patients: The Importance of Tissue Sampling
05/03/2023
Carolyn Ziemer; Jayson Miedema; Scott Jaros; Paul Googe
The authors present four cases in which wounds originally thought to be nonhealing ulcers or cellulitis were revealed to be cancerous upon tissue sampling.
The authors present four cases in which wounds originally thought to be nonhealing ulcers or cellulitis were revealed to be cancerous upon tissue sampling.
The authors present four cases...
05/03/2023
Wounds
Case Report
Pancreatic Panniculitis Secondary to Pancreatic Cyst With Lower Extremity Wounds as a Primary Presenting Feature: A Case Report and Literature Review
04/05/2023
Richard Simman, MD, FACS, FACCWS; Assava-Aree Chompunut; Lauren Fang; Samar Ayoub
The authors detail the cases of a 68-year-old male with pancreatic panniculitis characterized by erythematous wounds of the lower extremities and histology that included "ghost cells."
The authors detail the cases of a 68-year-old male with pancreatic panniculitis characterized by erythematous wounds of the lower extremities and histology that included "ghost cells."
The authors detail the cases of...
04/05/2023
Wounds
Case Report
Calciphylaxis and Skin Ulcers: A Diagnostic and Therapeutic Challenge
03/14/2023
Emanuela Francisco; Carlos Casimiro; Aline A. Gomes; Raquel Barros Pereira
In this case report, a 55-year-old White male was admitted with chronic necrotic ulcers on the right leg and an irregular violaceous plaque on the left leg under an initial suspicion of necrotizing fasciitis; following a diagnosis of...
In this case report, a 55-year-old White male was admitted with chronic necrotic ulcers on the right leg and an irregular violaceous plaque on the left leg under an initial suspicion of necrotizing fasciitis; following a diagnosis of...
In this case report, a...
03/14/2023
Wounds
Case Report
Platelet-rich Plasma Injection for Enterocutaneous Fistula: A Case Report
12/28/2022
Limin Bai; Gang Xu; Haijun Lin
A 52-year-old male patient diagnosed with an enterocutaneous fistula was treated with one application of platelet-rich plasma and saw fistula closure within 2 weeks.
A 52-year-old male patient diagnosed with an enterocutaneous fistula was treated with one application of platelet-rich plasma and saw fistula closure within 2 weeks.
A 52-year-old male patient...
12/28/2022
Wounds
Review
Atypical Ulcers: A Stepwise Approach for Clinicians
09/22/2022
Igor A. Altman; Maria M. Tsoukas; Melissa A. Nickles, BA; William J. Ennis; Nadera Sweiss
The authors share a stepwise approach for identifying, diagnosing, and treating atypical ulcers in this review.
The authors share a stepwise approach for identifying, diagnosing, and treating atypical ulcers in this review.
The authors share a stepwise...
09/22/2022
Wounds
Review
Understanding the Zebras of Wound Care: An Overview of Atypical Wounds
05/03/2022
Elizabeth A. Ansert, MA, DPM, MBA; Weldon Murry; Donald Cohen, DPM; Anthony Tickner, DPM, FRCPS, FACCWS, FAPWH, FAPWCA; Samuel Gorelik, DPM
This review provides a general overview of various atypical wound etiologies, clinical presentations and appearance, and current treatment protocols.
This review provides a general overview of various atypical wound etiologies, clinical presentations and appearance, and current treatment protocols.
This review provides a general...
05/03/2022
Wounds
Case Report
Atypical Ulcer Arising on Stasis Dermatitis: Achromic Melanoma
03/03/2022
Valentina Dini; Angelo D'Erme; Giulia Davini; Marco Romanelli; Barbara Loggini; Agata Janowska; Cristian Fidanzi; Giovanni Bagnoni
The authors report a very rare case of malignant melanoma in a 70-year-old female with stasis dermatitis.
The authors report a very rare case of malignant melanoma in a 70-year-old female with stasis dermatitis.
The authors report a very rare...
03/03/2022
Wounds
Original Research
Evaluation of A Multilayer Antimicrobial Foam Dressing Indicated for Use on Surgical Incisions
12/18/2025
This article examines clinician experiences using a multilayer antimicrobial surgical incision dressing prophylactically in low-risk orthopedic and other surgical patients.
This article examines clinician experiences using a multilayer antimicrobial surgical incision dressing prophylactically in low-risk orthopedic and other surgical patients.
This article examines clinician...
12/18/2025
Wounds
Clinical Trial Protocol
A Multicenter Hybrid Platform Trial Evaluating Amniotic Tissue Grafts in Chronic Wounds: A Real-World Evidence Protocol for Diabetic Foot and Venous Leg Ulcers
12/11/2025
This trial protocol describes a pragmatic hybrid real-world evidence design assessing trilayer versus single-layer amniotic grafts for diabetic and venous leg ulcers.
This trial protocol describes a pragmatic hybrid real-world evidence design assessing trilayer versus single-layer amniotic grafts for diabetic and venous leg ulcers.
This trial protocol describes a...
12/11/2025
Wounds
Original Research
Nonhealing Wound Debridement Using a Finger-Mounted Debridement Tool
12/09/2025
This study assesses a novel finger-mounted debridement tool's usability, patient tolerability, and wound accessibility in managing chronic nonhealing wounds.
This study assesses a novel finger-mounted debridement tool's usability, patient tolerability, and wound accessibility in managing chronic nonhealing wounds.
This study assesses a novel...
12/09/2025
Wounds
Original Research
Patient-Reported Outcomes Favor Below-Knee Over Above-Knee Amputation in Patients With Nontraumatic Lower Extremity Wounds
12/04/2025
This study evaluates long-term pain, psychological well-being, resilience, and functional outcomes after above- versus below-knee amputation for chronic lower extremity wounds.
This study evaluates long-term pain, psychological well-being, resilience, and functional outcomes after above- versus below-knee amputation for chronic lower extremity wounds.
This study evaluates long-term...
12/04/2025
Wounds
Case Report
Challenges in Cadaveric Skin Graft Survival in Organ Transplant Recipients on Immunosuppressive Regimens: A Case Report
11/17/2025
Steven Tohmasi, MD, MPHS; Carolyn Tsung, BA; Ariana Naaseh, MD, MPHS; Jennifer Yu, MD, MPHS; John P. Kirby, MD; Lindsay M. Kranker
11/17/2025
Wounds
Original Research
Photobiomodulation in Wounds of Individuals With Diabetes: A Nonrandomized Pilot Study
11/17/2025
Beatriz Barbieri Bortolozo, MSc; Amanda Ramiro Gomes da Silva, MSc; Thais Paulino Prado, PhD; Bianca Campos Oliveira, PhD; Joseane Morari, PhD; Flávia Cristina Zanchetta, PhD; Eliana Pereira Araújo, PhD; Beatriz Guitton Renaud Baptista de Oliveira, PhD; Bruna Maiara Ferreira Barreto Pires, BSN, PhD; Priscila Peruzzo Apolinario, PhD; Maria Helena M. Lima, RN, PhD
This prospective study examined the impact of photobiomodulation on lower extremity wounds in patients with diabetes over the course of 12 weeks.
This prospective study examined the impact of photobiomodulation on lower extremity wounds in patients with diabetes over the course of 12 weeks.
This prospective study examined...
11/17/2025
Wounds
Original Research
Effect of Negative Pressure Wound Therapy with Instillation and Dwell Time on Health Care Utilization and Costs in South Africa
11/03/2025
Maeyane S. Moeng; Suleman Vadia, MBChB; Ashley W. Collinsworth, ScD, MPH; Siobhan Lookess, BSc, PGDip; Paolo Capelli
The authors of this article examine the utilization and cost impact of negative pressure wound therapy with instillation and dwell time in South Africa.
The authors of this article examine the utilization and cost impact of negative pressure wound therapy with instillation and dwell time in South Africa.
The authors of this article...
11/03/2025
Wounds
Original Research
Use of a Novel Debriding Agent Based on Collagenase and Hyaluronate Lyase to Enhance Angiogenesis, Stimulate Healing, and Reduce Pain in Chronic Cutaneous Wounds
10/31/2025
Jorge Adrián Garza-Cerna, MD, MSc; Gabriel Ángel Mecott-Rivera, MD, PhD; Yanko Castro-Govea, MD, PhD; José Juan Pérez-Trujillo, PhD; Roberto Montes de Oca-Luna, MD, PhD; Daniel Salas-Treviño, PhD; Valeria Kopytina, PhD; Jorge López Berroa, MD
This study evaluated the safety and efficacy of a novel debriding agent comprised of collagenases G and H, and hyaluronate lyase, in chronic wounds.
This study evaluated the safety and efficacy of a novel debriding agent comprised of collagenases G and H, and hyaluronate lyase, in chronic wounds.
This study evaluated the safety...
10/31/2025
Wounds
Case Report
Recurrent Martorell Ulcer in a Patient With Hypertension: A Therapeutic Success With Pentoxifylline
10/22/2025
This case describes pentoxifylline for Martorell ulcer when antihypertensive targets preclude standard therapies, highlighting vigilance and management in cerebrovascular comorbidity.
This case describes pentoxifylline for Martorell ulcer when antihypertensive targets preclude standard therapies, highlighting vigilance and management in cerebrovascular comorbidity.
This case describes...
10/22/2025
Wounds
Literature Review
Advancing Chronic Wound Care With Near-Infrared Spectroscopy Imaging: Clinical Applications, Measurement Parameters, and Insights Into Healing Dynamics
10/21/2025
Alisha Oropallo, MD; Alex G. Ortega-Loayza, MD, MCR; Holly Korzendorfer, PT, PhD, CWS; Francis James, BFA; Peggy Dotson, RN, BS; Anna Khimchenko, PhD; Vickie R. Driver, DPM, MS; Sharon Eve Sonenblum, PhD
This review delineates near-infrared spectroscopy modalities, measurement parameters, and clinical applications for real-time microvascular assessment in wound management and decision-making.
This review delineates near-infrared spectroscopy modalities, measurement parameters, and clinical applications for real-time microvascular assessment in wound management and decision-making.
This review delineates...
10/21/2025
Wounds

Multimedia

Preview Image
Videos
Performing a Wound Biopsy to Diagnose Atypical Wounds
10/28/2022
Windy E. Cole, DPM, CWSP, FACCWS
In this video, Dr. Windy E. Cole reports the results of a case series in which 3 patients who presented with rare diseases—atypical wounds—were diagnosed via biopsy results. Data were presented at the 2022 SAWC Fall.
In this video, Dr. Windy E. Cole reports the results of a case series in which 3 patients who presented with rare diseases—atypical wounds—were diagnosed via biopsy results. Data were presented at the 2022 SAWC Fall.
In this video, Dr. Windy E. Cole...
10/28/2022
Wounds
Viewpoints
CMS CTP Pricing Changes Could Shift Wound Care Volume to Academic Centers—and Limit Patient Access
01/15/2026
Alton R. Johnson, Jr., DPM, DABPM, FACPM, FASPS, CWSP
Finalized CMS pricing and regulatory changes for cellular and tissue-based products (CTPs) are expected to significantly alter where—and how—wound care is delivered. In this interview, Alton R. Johnson, Jr., DPM, explains why private...
Finalized CMS pricing and regulatory changes for cellular and tissue-based products (CTPs) are expected to significantly alter where—and how—wound care is delivered. In this interview, Alton R. Johnson, Jr., DPM, explains why private...
Finalized CMS pricing and...
01/15/2026
Wounds
Viewpoints
From Uncertainty to Clarity: How MIMOSA Could Help Clinicians Navigate CTP Regulations With Objective Imaging
01/14/2026
01/14/2026
Wounds
Viewpoints
From Uncertainty to Clarity: How MIMOSA Could Help Clinicians Navigate CTP Regulations With Objective Imaging
01/14/2026
Chris Boodoo, MSc; Karen Cross, MD, PhD
In this video discussion, Chris Boodoo, MSc, and Karen Cross, MD, PhD, discuss how technology companies keep up with the uncertainty surrounding cellular- and tissue-based products (CTPs).
In this video discussion, Chris Boodoo, MSc, and Karen Cross, MD, PhD, discuss how technology companies keep up with the uncertainty surrounding cellular- and tissue-based products (CTPs).
In this video discussion, Chris...
01/14/2026
Wounds
Viewpoints
How CTP Regulatory Changes Could Impact Wound Type and Subpopulations
01/13/2026
Caroline E. Fife, MD, FAAFP, CWS, FUHM
As Dr. Fife notes, reduced margins may challenge home-based care previously supported by higher product profits; however, low-cost products can still yield margins, especially for large wounds,
As Dr. Fife notes, reduced margins may challenge home-based care previously supported by higher product profits; however, low-cost products can still yield margins, especially for large wounds,
As Dr. Fife notes, reduced...
01/13/2026
Wounds
Viewpoints
Is Mobile Wound Care Sustainable in Light of CTP/CAMPs Regulations? 
01/12/2026
Zwelithini Tunyiswa, BA; Ryan P. Dirks, PA-C
With tightening skin substitute reimbursement and increasing regulatory scrutiny, many are questioning whether mobile wound care remains sustainable. Drawing on real-world experience, this discussion reframes sustainability as a...
With tightening skin substitute reimbursement and increasing regulatory scrutiny, many are questioning whether mobile wound care remains sustainable. Drawing on real-world experience, this discussion reframes sustainability as a...
With tightening skin substitute...
01/12/2026
Wounds
Viewpoints
Focus on Compliance: Observations on the Impact of Skin Substitute Fraud, Waste, and Abuse
01/09/2026
Zwelithini Tunyiswa; Ryan P. Dirks, PA-C
In Part 2 of this interview series, Zwelithini Tunyiswa, BS, and Ryan Dirks, PA-C, of Open Wound Research confront the emotional and operational fallout of intensified fraud, waste, and abuse scrutiny in wound care—particularly as it relates...
In Part 2 of this interview series, Zwelithini Tunyiswa, BS, and Ryan Dirks, PA-C, of Open Wound Research confront the emotional and operational fallout of intensified fraud, waste, and abuse scrutiny in wound care—particularly as it relates...
In Part 2 of this...
01/09/2026
Wounds
Viewpoints
The Impact of CTP Changes on Provider Types
01/08/2026
Caroline E. Fife, MD, FAAFP, CWS, FUHM
Dr. Fife discusses the effects of CTP changes on hospital-based, mobile clinicians, skilled nursing and other settings, also touching on considerations with product handling.
Dr. Fife discusses the effects of CTP changes on hospital-based, mobile clinicians, skilled nursing and other settings, also touching on considerations with product handling.
Dr. Fife discusses the effects...
01/08/2026
Wounds
Viewpoints
Skin Substitutes' Influence on Wound Practice Sustainability: Historic and Research-Based Context
01/06/2026
Zwelithini Tunyiswa; Ryan P. Dirks, PA-C
In part 1 of this interview series, Zwelithini Tunyiswa, BS, and Ryan Dirks, PA-C, of Open Wound Research examine how mobile wound care has been reshaped by the rapid rise of cellular and acellular matrix products (CAMPs)/skin substitutes.
In part 1 of this interview series, Zwelithini Tunyiswa, BS, and Ryan Dirks, PA-C, of Open Wound Research examine how mobile wound care has been reshaped by the rapid rise of cellular and acellular matrix products (CAMPs)/skin substitutes.
In part 1 of this interview...
01/06/2026
Wounds
Matthew Regulski, DPM, FFPM, RCPS (Glasgow), DABMSP
Viewpoints
Cutting Costs, Raising Standards: The Case for Evidence-Based CTP Use
12/30/2025
Matthew J. Regulski, DPM, ABMSP, CMET, FAPWH(c)
CMS reimbursement reforms are reshaping the use of skin substitutes in wound care, phasing out high-cost, low-evidence products in favor of therapies backed by rigorous clinical data. New models like WISeR promote prior authorization to...
CMS reimbursement reforms are reshaping the use of skin substitutes in wound care, phasing out high-cost, low-evidence products in favor of therapies backed by rigorous clinical data. New models like WISeR promote prior authorization to...
CMS reimbursement reforms are...
12/30/2025
Wounds
Viewpoints
How CTP Changes Impact Providers, Patients, the Industry, and Policy
12/29/2025
Diane G. Weiss, CPC, CPB, CCP, CHRI
This speaker discusses how CTP changes affect various stakeholders, how prepared providers will be, whether regulatory efforts are fostering or stifling innovation, and what policy actions would ensure sustainable growth and fair competition...
This speaker discusses how CTP changes affect various stakeholders, how prepared providers will be, whether regulatory efforts are fostering or stifling innovation, and what policy actions would ensure sustainable growth and fair competition...
This speaker discusses how CTP...
12/29/2025
Wounds

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