NPs/PAs Can Play Expanding Role in Dermatology Clinical Research

During her presentation at the Masterclasses in Dermatology NP/PA Institute, Alexa Hetzel, DMSc, PA-C, director of clinical trials at Schweiger Dermatology in East Windsor, New Jersey, shared how nurse practitioners (NPs) and physician assistants (PAs) are well positioned to expand patient access to dermatology clinical trials while taking on roles ranging from sub-investigator to research leadership.

Dr Hetzel outlined why NPs and PAs are valuable to clinical research, the responsibilities they can assume, and practical steps for clinicians interested in becoming involved.

Research plays a central role in expanding therapeutic options, Dr Hetzel noted. Every approved therapy begins with volunteers and investigators and must progress through multiple phases of research before receiving US Food and Drug Administration approval. Clinical trials can also provide patients with access to innovative treatments while generating evidence that may shape future standards of care.

NPs and PAs bring several strengths to this process, including long-term patient relationships, disease expertise, and continuity of care. These relationships can help clinicians identify eligible trial participants, support retention, and educate patients during the informed consent process.

For NPs and PAs interested in research, opportunities can progress from research-interested clinician to sub-investigator and potentially principal investigator. Experience may also lead to roles in medical affairs, industry, contract research organization leadership, and advisory boards.

Within a clinical trial, NP and PA responsibilities may include screening and recruiting participants; interpreting inclusion and exclusion criteria; conducting protocol visits and safety assessments; reviewing laboratory results and electrocardiograms; documenting adverse events; and collaborating with sponsors, monitors, and research coordinators.

Clinicians do not need extensive research experience to begin, Dr Hetzel emphasized. Practical first steps include completing Good Clinical Practice training, identifying nearby research-active practices, asking to shadow a research visit, volunteering as a sub-investigator, and attending investigator meetings and journal clubs.

“Getting started requires curiosity, not years of experiences,” Dr Hetzel noted.

Opportunities for NPs and PAs may continue to expand as clinical research evolves. Dr Hetzel highlighted decentralized and hybrid trials, artificial intelligence-assisted recruitment, precision medicine and biomarkers, and greater leadership opportunities for NP and PA investigators.

For NPs and PAs considering clinical research, Dr Hetzel emphasized that their existing clinical skills and patient relationships can provide a foundation for participation.

“The opportunities are endless!” she stated.

Dr Hetzel also underscored the potential impact of participation at the individual patient level, noting that “one enrolled patient can change and progress science, as well as the patient’s life.”

Reference

Hetzel A. How to get involved in clinical trials. Presented at: Masterclasses in Dermatology NP/PA Institute; September 26–27, 2026; New York City, NY.