Standardized Cognitive Remediation Program Improves Function and Goal Attainment in Veterans With MS

A standardized, values-driven cognitive remediation program for veterans with multiple sclerosis (MS) shows early promise in improving patient-reported function, task efficiency, and engagement in meaningful activities, according to preliminary findings from the IMPACT-MS study.

The intervention consists of a 6-module, 7-week cognitive therapy protocol delivered by rehabilitation neuropsychologists. It targets deficits in processing speed, memory, attention, and executive function—domains commonly affected in MS. Patients received individualized therapy addressing both objectively measured impairments and self-reported concerns, with their values and personal goals guiding treatment focus.

“The brief, comprehensive treatment protocol also addressed the complex relations among mood, fatigue, and cognition,” researchers wrote. Cognitive and functional assessments were conducted before treatment, immediately afterward, and 6 months post-intervention.

As of December 2024, 5 participants have completed the protocol. All reported progress toward their long-term goals and full achievement of their short-term goals. Importantly, patients continued to experience cognitive symptoms and MS-related fatigue but noted improved management and greater ability to participate in daily life.

“Patients also reported improved task efficiency and increased participation in values-driven behavior,” the study noted.

This integrated prospective and retrospective study highlights the feasibility of implementing a standardized but adaptable intervention within clinical settings. The protocol was designed to be scalable, low-cost, and minimal risk—factors critical for broader deployment in routine MS care.

The authors concluded, “This novel, standardized yet adaptable cognitive remediation protocol shows promise as a minimal-risk, low-cost intervention.” Ongoing recruitment and longitudinal follow-up aim to further evaluate sustained benefits across MS phenotypes.

If validated in larger cohorts, this model could support wider access to cognitive therapy tailored to individual needs and personal goals, addressing a long-standing gap in MS symptom management.

Reference
Mariouw K, Fritz NE, Omar S, Memon AB. Impact-MS: a novel cognitive remediation program to enhance functional outcomes in veterans with Multiple Sclerosis. Presented at: CMSC 2025; May 28-31; Phoenix, AZ.