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Poll: Treating Acute Severe Ulcerative Colitis

Rebecca Mashaw
12/17/2024

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Conference Coverage
Mirikizumab Shows Progressive Histologic Improvement in Ulcerative Colitis, With Strong Rectal Response
05/06/2026
Jessica Garlewicz
The study uniquely focused on patients with baseline bowel urgency, integrating symptom burden with objective mucosal healing endpoints.
The study uniquely focused on patients with baseline bowel urgency, integrating symptom burden with objective mucosal healing endpoints.
The study uniquely focused on...
05/06/2026
Advances in Inflammatory Bowel Disease Network
Research Highlights
Early Endoscopic and Histologic Response With Guselkumab Predicts Long-Term Remission in UC
05/06/2026
Jessica Garlewicz
Endoscopic and histologic improvements early in treatment appear to serve as reliable indicators of sustained remission without corticosteroids.
Endoscopic and histologic improvements early in treatment appear to serve as reliable indicators of sustained remission without corticosteroids.
Endoscopic and histologic...
05/06/2026
Advances in Inflammatory Bowel Disease Network
Videos
Jean-Frederic Colombel, MD, on Disease Clearance With Mirikizumab in Ulcerative Colitis
05/06/2026
Jean-Frederic Colombel
Dr Colombel discusses his presentation at DDW 2026 on a post-doc analysis of the long-term outcomes of the LUCENT trial of mirikizumab, which showed that the IL-23p19 inhibitor achieved and maintained disease clearance for up to 4 years among...
Dr Colombel discusses his presentation at DDW 2026 on a post-doc analysis of the long-term outcomes of the LUCENT trial of mirikizumab, which showed that the IL-23p19 inhibitor achieved and maintained disease clearance for up to 4 years among...
Dr Colombel discusses his...
05/06/2026
Advances in Inflammatory Bowel Disease Network
RESEARCH INSIGHTS
Early Endoscopic and Histologic Response With Guselkumab Predicts Long-Term Remission in UC
05/06/2026
Jessica Garlewicz
At week 0, 66.8% to 77.3% of patients who achieved these endpoints went on to achieve corticosteroid-free clinical remission at week 92.
At week 0, 66.8% to 77.3% of patients who achieved these endpoints went on to achieve corticosteroid-free clinical remission at week 92.
At week 0, 66.8% to 77.3% of...
05/06/2026
Advances in Inflammatory Bowel Disease Network

Latest News

RESEARCH INSIGHTS
Early Endoscopic and Histologic Response With Guselkumab Predicts Long-Term Remission in UC
05/06/2026
Jessica Garlewicz
At week 0, 66.8% to 77.3% of patients who achieved these endpoints went on to achieve corticosteroid-free clinical remission at week 92.
At week 0, 66.8% to 77.3% of patients who achieved these endpoints went on to achieve corticosteroid-free clinical remission at week 92.
At week 0, 66.8% to 77.3% of...
05/06/2026
Advances in Inflammatory Bowel Disease Network
News
Oral Icotrokinra Demonstrates Efficacy in Ulcerative Colitis Regardless of Prior Advanced Therapy Exposure
05/05/2026
Jessica Garlewicz
While response rates were generally higher in patients without prior advanced therapy failure, meaningful improvements were still seen in those with treatment-resistant disease.
While response rates were generally higher in patients without prior advanced therapy failure, meaningful improvements were still seen in those with treatment-resistant disease.
While response rates were...
05/05/2026
Advances in Inflammatory Bowel Disease Network
Research Review
Early “Top-Down” Therapy Reduces Long-Term Complications in Crohn’s Disease
05/05/2026
Jessica Garlewicz
Disease progression and hospitalizations were more common in the step-up group, with higher rates of stricturing and penetrating complications.
Disease progression and hospitalizations were more common in the step-up group, with higher rates of stricturing and penetrating complications.
Disease progression and...
05/05/2026
Advances in Inflammatory Bowel Disease Network
Research Review
Upper GI Crohn’s Disease Remains Underrecognized, Lacks Standardized Guidance
04/02/2026
Jessica Garlewicz
A recent review noted a lack of consistent diagnostic definitions across modalities, complicating clinical interpretation and research comparisons.
A recent review noted a lack of consistent diagnostic definitions across modalities, complicating clinical interpretation and research comparisons.
A recent review noted a lack of...
04/02/2026
Advances in Inflammatory Bowel Disease Network
Research Summary
Advanced Therapy May Reduce Antibiotic Dependence in Chronic Pouchitis After IPAA
03/18/2026
Jessica Garlewicz
These findings support considering immune-mediated therapy in selected patients although more research is needed to identify the patients likely to benefit most from advanced therapy.
These findings support considering immune-mediated therapy in selected patients although more research is needed to identify the patients likely to benefit most from advanced therapy.
These findings support...
03/18/2026
Advances in Inflammatory Bowel Disease Network
Research Review
New Meta-Analysis Highlights Burden of MASLD Among IBD Patients
02/03/2026
Rebecca Mashaw
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from...
02/03/2026
Gastroenterology
News
Medicare Will Cover GLP-1s for Obesity Under Deal with Pharma
11/06/2025
Rebecca Mashaw
Administration officials said the new lower prices also will be provided for Medicaid programs, with prices and timing decided state by state as they opt in.
Administration officials said the new lower prices also will be provided for Medicaid programs, with prices and timing decided state by state as they opt in.
Administration officials said...
11/06/2025
Advances in Inflammatory Bowel Disease Network
FDA alert
FDA Alert
FDA Approves Updated Indication for Upadacitinib in IBD
10/14/2025
Rebecca Mashaw
The new indication allows for upadacitinib therapy among patients who have received any approved systemic therapy for IBD “in the event TNF blockers are clinically inadvisable."
The new indication allows for upadacitinib therapy among patients who have received any approved systemic therapy for IBD “in the event TNF blockers are clinically inadvisable."
The new indication allows for...
10/14/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Concomitant Medications Do Not Alter Efficacy of Advanced Therapies in Ulcerative Colitis, Study Finds
09/18/2025
Jessica Garlewicz
New study findings suggest that most baseline concomitant therapies do not require modification or exclusion when initiating advanced therapy in clinical trial settings.
New study findings suggest that most baseline concomitant therapies do not require modification or exclusion when initiating advanced therapy in clinical trial settings.
New study findings suggest that...
09/18/2025
Advances in Inflammatory Bowel Disease Network
Research Highlights
Persistent Prothrombotic State Observed in Patients With ASUC
09/04/2025
Rebecca Mashaw
New findings show patients with acute severe ulcerative colitis remain at elevated thrombotic risk for up to 12 weeks post-hospitalization.
New findings show patients with acute severe ulcerative colitis remain at elevated thrombotic risk for up to 12 weeks post-hospitalization.
New findings show patients with...
09/04/2025
Advances in Inflammatory Bowel Disease Network

Latest Podcasts

IBD Drive time logo
Expert Insights
IBD Drive Time: Colleen Kelly, MD, on Obesity and IBD
04/20/2026
Raymond Cross, MD; Colleen Kelly, MD
Host Raymond Cross, MD, calls on Dr Colleen Kelly to discuss the increasing prevalence of obesity among patients with IBD, how obesity can complicate Crohn's disease and ulcerative colitis, and the role of GLP-1 RAs and bariatric surgery in...
Host Raymond Cross, MD, calls on Dr Colleen Kelly to discuss the increasing prevalence of obesity among patients with IBD, how obesity can complicate Crohn's disease and ulcerative colitis, and the role of GLP-1 RAs and bariatric surgery in...
Host Raymond Cross, MD, calls on...
04/20/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Jared Magee, MD, on Men's Health in IBD
04/07/2026
Raymond Cross, MD; Jared Magee, MD
Drs Raymond Cross and Jared Magee discuss some of the special concerns that affect men with inflammatory bowel disease, from cardiac concerns to sexual dysfunction and assessing for anal cancer.
Drs Raymond Cross and Jared Magee discuss some of the special concerns that affect men with inflammatory bowel disease, from cardiac concerns to sexual dysfunction and assessing for anal cancer.
Drs Raymond Cross and Jared...
04/07/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: The Best of ECCO 2026
03/25/2026
Raymond Cross, MD; Sara Horst, MD; Jordan Axelrad, MD
Host Raymond Cross, MD, is joined by Drs Sara Horst and Jordan Axelrad to review the findings of their picks for the best presentations from the European Crohn's and Colitis Organization meeting held earlier this year.
Host Raymond Cross, MD, is joined by Drs Sara Horst and Jordan Axelrad to review the findings of their picks for the best presentations from the European Crohn's and Colitis Organization meeting held earlier this year.
Host Raymond Cross, MD, is...
03/25/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Shirley Cohen-Mekelburg, MD on Self-Care for IBD Patients
03/17/2026
Shirley Cohen-Mekelburg; Raymond Cross, MD
Host Raymond Cross, MD, calls on Dr Shirley Mekelburg-Cohen to discuss the importance of self-care among patients with IBD, what self-care consists of, and how to help patients learn to partner with their clinicians in controlling their...
Host Raymond Cross, MD, calls on Dr Shirley Mekelburg-Cohen to discuss the importance of self-care among patients with IBD, what self-care consists of, and how to help patients learn to partner with their clinicians in controlling their...
Host Raymond Cross, MD, calls on...
03/17/2026
Advances in Inflammatory Bowel Disease Network
New IBD Logo
Expert Insights
IBD Drive Time: James Lewis, MD, on Dysplasia Surveillance in IBD
02/23/2026
Raymond Cross, MD; James D. Lewis, MD
Dr James Lewis from the University of Pennsylvania and host Dr Raymond Cross discuss the risk of colon cancer among patients with inflammatory bowel disease, the importance of appropriate surveillance, and special considerations for choosing...
Dr James Lewis from the University of Pennsylvania and host Dr Raymond Cross discuss the risk of colon cancer among patients with inflammatory bowel disease, the importance of appropriate surveillance, and special considerations for choosing...
Dr James Lewis from the...
02/23/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Expert Insights
IBD Drive Time: Raymond Cross, MD, on Ostomy Complications
01/13/2026
Raymond Cross, MD; Sara Horst, MD
In this episode of IBD Drive Time, Dr Raymond Cross switches seats and acts as the guest with Sara Horst, MD, as host, to discuss the complexities of ostomy complications.
In this episode of IBD Drive Time, Dr Raymond Cross switches seats and acts as the guest with Sara Horst, MD, as host, to discuss the complexities of ostomy complications.
In this episode of IBD Drive...
01/13/2026
Advances in Inflammatory Bowel Disease Network
IBD Drive time logo
Conference Coverage
IBD Drive Time: The Best of ACG With Dr Sara Horst
12/01/2025
Raymond Cross, MD; Sara Horst, MD
Dr Sara Horst joins IBD Drive Time host Dr Raymond Cross to review their choices for the best presentations from the American College of Gastroenterology annual meeting.
Dr Sara Horst joins IBD Drive Time host Dr Raymond Cross to review their choices for the best presentations from the American College of Gastroenterology annual meeting.
Dr Sara Horst joins IBD Drive...
12/01/2025
Advances in Inflammatory Bowel Disease Network
IBD Drive Time
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IBD Drive Time: Freddy Caldera, MD, on Vaccines for Patients With IBD
11/03/2025
Raymond Cross, MD; Freddy Caldera, DO
Freddy Caldera, DO, returns to talk to IBD Drive Time host Raymond Cross, MD, about the best current recommendations for patients with IBD in the midst of controversy and confusion.
Freddy Caldera, DO, returns to talk to IBD Drive Time host Raymond Cross, MD, about the best current recommendations for patients with IBD in the midst of controversy and confusion.
Freddy Caldera, DO, returns to...
11/03/2025
Advances in Inflammatory Bowel Disease Network
IBD Drive Time
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IBD Drive Time: Megan Riehl, PsyD, on Mental Health and IBD
10/22/2025
Raymond Cross, MD; Megan Riehl, PsyD
Clinical psychologist Megan Riehl, Psy D, talks with IBD Drive Time host Raymond Cross, MD, about the prevalence of anxiety and depression and even post-traumatic stress disorder among patients with inflammatory bowel disease--and how...
Clinical psychologist Megan Riehl, Psy D, talks with IBD Drive Time host Raymond Cross, MD, about the prevalence of anxiety and depression and even post-traumatic stress disorder among patients with inflammatory bowel disease--and how...
Clinical psychologist Megan...
10/22/2025
Advances in Inflammatory Bowel Disease Network
IBD Drive Time
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IBD Drive Time: Florian Rieder, MD, on Stricturing and Penetrating Crohn's Disease
10/06/2025
Raymond Cross, MD; Florian Rieder
Host Raymond Cross, MD, welcomes back Dr Florian Rieder, an internationally recognized expert in penetrating and stricturing complications of Crohn's disease, to talk about diagnosing, performing endoscopy, and treating this challenging...
Host Raymond Cross, MD, welcomes back Dr Florian Rieder, an internationally recognized expert in penetrating and stricturing complications of Crohn's disease, to talk about diagnosing, performing endoscopy, and treating this challenging...
Host Raymond Cross, MD, welcomes...
10/06/2025
Advances in Inflammatory Bowel Disease Network

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