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Research Summary
Refined Fibrosis Screening Criteria Reduce Eligible Population, Improve Detection of Advanced Liver Disease
08/10/2026
Jessica Garlewicz
Individuals meeting the refined criteria for liver stiffness measurement had approximately sixfold higher 10-year risks of both incident cirrhosis (0.99% vs 0.18%) and liver-related death (0.40% vs 0.07%) over patients who did not meet the...
Individuals meeting the refined criteria for liver stiffness measurement had approximately sixfold higher 10-year risks of both incident cirrhosis (0.99% vs 0.18%) and liver-related death (0.40% vs 0.07%) over patients who did not meet the...
Individuals meeting the refined...
08/10/2026
Gastroenterology
Gut Check logo
Expert Insights
Gut Check: Benjamin Lebwohl, MD, on Celiac Disease
07/30/2026
Brian E. Lacy, PhD, MD; Benjamin Lebwohl
Dr Brian Lacy hosts celiac disease expert Dr Benjamin Lebwohl to explain the prevalence of the disease, the complexities of accurate diagnosis, and the importance of not relying on symptoms alone.
Dr Brian Lacy hosts celiac disease expert Dr Benjamin Lebwohl to explain the prevalence of the disease, the complexities of accurate diagnosis, and the importance of not relying on symptoms alone.
Dr Brian Lacy hosts celiac...
07/30/2026
Gastroenterology
FDA Approval
FDA Approves SimpleScreen CRC Blood Test for U.S. Colorectal Cancer Screening
07/28/2026
Rebecca Mashaw
FDA approval was based on results of PREEMPT CRC, a prospective clinical validation study that enrolled more than 48,000 asymptomatic, average-risk adults between the ages of 45 and 85.
FDA approval was based on results of PREEMPT CRC, a prospective clinical validation study that enrolled more than 48,000 asymptomatic, average-risk adults between the ages of 45 and 85.
FDA approval was based on...
07/28/2026
Gastroenterology
Research Highlights
Tenapanor Linked to Earlier, Sustained Symptom Relief in IBS-C
07/23/2026
Rebecca Mashaw
A novel post hoc analysis demonstrates that tenapanor reduces the time to first response in irritable bowel syndrome with constipation compared to placebo.
A novel post hoc analysis demonstrates that tenapanor reduces the time to first response in irritable bowel syndrome with constipation compared to placebo.
A novel post hoc analysis...
07/23/2026
Gastroenterology
Research Insights
U.S. Dietary Guideline Changes May Conflict With Liver Health Findings
07/16/2026
Rebecca Mashaw
An analysis of just under 11,000 US adults suggest that dietary recommendations for liver health may benefit from greater emphasis on specific food sources rather than total nutrient intake alone.
An analysis of just under 11,000 US adults suggest that dietary recommendations for liver health may benefit from greater emphasis on specific food sources rather than total nutrient intake alone.
An analysis of just under 11,000...
07/16/2026
Gastroenterology
Research Review
IBS-C Review Emphasizes Multisymptom Management Beyond Constipation and Pain
07/15/2026
Rebecca Mashaw
A narrative review synthesizes current evidence on diagnosis of constipation-dominant IBS, its differentiation from chronic idiopathic constipation (CIC), and pharmacologic and nonpharmacologic approaches that target multiple gastrointestinal...
A narrative review synthesizes current evidence on diagnosis of constipation-dominant IBS, its differentiation from chronic idiopathic constipation (CIC), and pharmacologic and nonpharmacologic approaches that target multiple gastrointestinal...
A narrative review synthesizes...
07/15/2026
Gastroenterology
Research Review
Tenapanor Improves IBS-C Symptoms in Systematic Review and Meta-Analysis
07/15/2026
Rebecca Mashaw
A recent systematic review and meta-analysis concluded that tenapanor is effective for IBS-C symptom management but investigators emphasized the need for additional studies to evaluate its long-term safety.
A recent systematic review and meta-analysis concluded that tenapanor is effective for IBS-C symptom management but investigators emphasized the need for additional studies to evaluate its long-term safety.
A recent systematic review and...
07/15/2026
Gastroenterology
Robert Gish
Expert Insights
Robert Gish, MD, on Advances in Managing Hepatitis B and D
07/15/2026
Robert Gish, MD
Dr Gish discusses the recent approval of bulevirtide for the treatment of hepatitis D, and the importance of screening and monitoring patients with hepatitis B for hepatitis D to enable effective treatment.
Dr Gish discusses the recent approval of bulevirtide for the treatment of hepatitis D, and the importance of screening and monitoring patients with hepatitis B for hepatitis D to enable effective treatment.
Dr Gish discusses the recent...
07/15/2026
Gastroenterology
Research Highlights
AI-Assisted Colonoscopy May Offset Impact of Suboptimal Bowel Preparation
07/13/2026
Jessica Garlewicz
The findings of a recent study suggest a potential role for AI in colonoscopy for maintaining quality metrics when bowel preparation is suboptimal.
The findings of a recent study suggest a potential role for AI in colonoscopy for maintaining quality metrics when bowel preparation is suboptimal.
The findings of a recent study...
07/13/2026
Gastroenterology
Research Summary
Low-FODMAP Diet May Improve IBS-D Through Effects on Mast Cells and Intestinal Barrier Function
07/13/2026
Jessica Garlewicz
Patients with diarrhea-predominant irritable bowel syndrome showed improvement in colonic barrier dysfunction and mast cell recruitment after following a low-FODMAP diet, a recent study showed.
Patients with diarrhea-predominant irritable bowel syndrome showed improvement in colonic barrier dysfunction and mast cell recruitment after following a low-FODMAP diet, a recent study showed.
Patients with...
07/13/2026
Gastroenterology
Manal Abdelmalek
How I Treat
How I Treat MASLD/MASH: Manal Abdelmalek, MD
07/13/2026
Manal Abdelmalek, MD
Dr Abdelmalek reviews her approach to screening, diagnosis, treatment, and monitoring of metabolic dysfunction-associated steatotic liver disease.
Dr Abdelmalek reviews her approach to screening, diagnosis, treatment, and monitoring of metabolic dysfunction-associated steatotic liver disease.
Dr Abdelmalek reviews her...
07/13/2026
Gastroenterology

News

FDA Approval
FDA Approves SimpleScreen CRC Blood Test for U.S. Colorectal Cancer Screening
07/28/2026
Rebecca Mashaw
FDA approval was based on results of PREEMPT CRC, a prospective clinical validation study that enrolled more than 48,000 asymptomatic, average-risk adults between the ages of 45 and 85.
FDA approval was based on results of PREEMPT CRC, a prospective clinical validation study that enrolled more than 48,000 asymptomatic, average-risk adults between the ages of 45 and 85.
FDA approval was based on...
07/28/2026
Gastroenterology
Research Highlights
GLP-1 RAs Linked to Lower Risk of Hepatic Complications in MASLD and T2D
06/11/2026
Jessica Garlewicz
A real-world cohort study found that patients with MASLD and type 2 diabetes who were not using GLP-1 RAs had a signficantly higher rate of hepatic complications compared to patients receiving GLP-1 therapy.
A real-world cohort study found that patients with MASLD and type 2 diabetes who were not using GLP-1 RAs had a signficantly higher rate of hepatic complications compared to patients receiving GLP-1 therapy.
A real-world cohort study found...
06/11/2026
Gastroenterology
Research Insights
IBS-C Microbiome Signatures Offer Insights Into Parkinson’s-Related Constipation
06/09/2026
Rebecca Mashaw
New research highlights important similarities and differences between IBS-C and Parkinson’s disease–associated constipation.
New research highlights important similarities and differences between IBS-C and Parkinson’s disease–associated constipation.
New research highlights...
06/09/2026
Gastroenterology
Research Review
Colonoscopy Associated With Lower Colorectal Cancer Risk in Adults Aged 40–49 Years
06/03/2026
Jessica Garlewicz
Investigators observed a lower cumulative incidence of CRC among individuals who underwent colonoscopy across both age groups studied.
Investigators observed a lower cumulative incidence of CRC among individuals who underwent colonoscopy across both age groups studied.
Investigators observed a lower...
06/03/2026
Gastroenterology
Research Insights
Early-Onset Colorectal Cancer Survivors Report Persistent Sexual Health Challenges
05/27/2026
Rebecca Mashaw
A new study adds to growing evidence that sexual and reproductive health issues are common yet frequently overlooked among younger colorectal cancer survivors.
A new study adds to growing evidence that sexual and reproductive health issues are common yet frequently overlooked among younger colorectal cancer survivors.
A new study adds to growing...
05/27/2026
Gastroenterology
Research Review
Synchronous Colon Cancer Not Associated With Worse Survival in Stage I–III Disease
05/27/2026
Jessica Garlewicz
The findings provide reassurance regarding prognosis in patients presenting with multiple primary tumors.
The findings provide reassurance regarding prognosis in patients presenting with multiple primary tumors.
The findings provide reassurance...
05/27/2026
Gastroenterology
Research Review
High Rehospitalization and Mortality Rates Persist After ICI-Associated Colitis
05/06/2026
Jessica Garlewicz
Rehospitalization remained common among patients who experienced immune checkpoint inhibitor-associated colitis, indicating that adverse effects often persist beyond ICI exposure.
Rehospitalization remained common among patients who experienced immune checkpoint inhibitor-associated colitis, indicating that adverse effects often persist beyond ICI exposure.
Rehospitalization remained...
05/06/2026
Gastroenterology
Research Highlights
MAPI Offers New Biomarker in Screening for MetALD and ALD
04/23/2026
Jessica Garlewicz
MetALD-ALD Prediction Index (MAP) proved to be the top-performing model among all commonly used indirect alcohol biomarkers.
MetALD-ALD Prediction Index (MAP) proved to be the top-performing model among all commonly used indirect alcohol biomarkers.
MetALD-ALD Prediction Index...
04/23/2026
Gastroenterology
News
Lifetime Alcohol Intake Linked to Colorectal Cancer Risk
02/11/2026
Jessica Garlewicz
For gastroenterologists, the key takeaway is that cumulative alcohol exposure and long-term drinking patterns matter when assessing CRC risk.
For gastroenterologists, the key takeaway is that cumulative alcohol exposure and long-term drinking patterns matter when assessing CRC risk.
For gastroenterologists, the key...
02/11/2026
Gastroenterology
Research Review
New Meta-Analysis Highlights Burden of MASLD Among IBD Patients
02/03/2026
Rebecca Mashaw
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from more than 1.5 million individuals, providing the most extensive evidence yet on MASLD’s prevalence and associated factors in patients with Crohn’s disease and ulcerative colitis.
The study draws on data from...
02/03/2026
Gastroenterology

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