Virtual Endoscopy Can Detect More Dysplasia in Patients With Inflammatory Bowel Disease
Background:
Epithelial dysplasia is a risk for colon cancer in patients with long-standing inflammatory bowel disease. The rates of dysplasia detection using virtual-based versus dye-based chromoendoscopy remain controversial. Therefore, we conducted a systematic review and meta-analysis to analyze the available data on this topic.
Methods:
We identified potentially eligible studies from the MEDLINE and EMBASE databases, searching from inception to September 2024, to compare the differences in virtual-based (VCE) and dye-based chromoendoscopy (DCE) in detecting dysplasia in inflammatory bowel disease patients. Studies are needed to compare dysplasia detection rates between DCE and VCE in inflammatory bowel disease patients to be included. Effect size and 95% confidence intervals (CIs) were combined using the generic inverse variance method. All statistical analyses were performed by Review Manager 5.4.
Results:
Our meta-analysis included 11 studies that met the eligibility criteria. There were 1,395 participants, with a mean age of 50.7 years, and 52% were males. We found that patients undergoing VCE had a 43% higher rate of detecting dysplasia than DCE (95% CI: 1.04, 1.98; I<sup>2</sup> = 0%; <italic>P =</italic>0.03) in inflammatory bowel disease patients after post-sensitivity analysis.
Conclusions:
Our study revealed that VCE is superior in detecting dysplasia lesions in inflammatory bowel disease patients. Large-scale cohort studies may be required to reinforce this relationship.
