Poster
113
(#113) Clinical Characteristics and Productivity Losses Among Individuals Diagnosed With Narcolepsy or Idiopathic Hypersomnia
Psych Congress 2025
Abstract: Background: Narcolepsy and idiopathic hypersomnia (IH) are associated with higher comorbidity burden and healthcare costs, compared with the general population. This study described clinical characteristics and productivity losses in individuals with narcolepsy or IH.
Methods: MarketScan® linked to the Health and Productivity Management (HPM) Database (01/2017‒12/2023) identified individuals with narcolepsy or IH, matched to individuals without narcolepsy/IH. Clinical characteristics, short-term disability (STD), long-term disability (LTD), workplace absence (WA), and workers' compensation (WC) days missed from work were descriptively analyzed.
Results: Individuals with versus without narcolepsy or IH had a higher prevalence of cardiovascular (eg, hypertension; narcolepsy: 40.9% vs 26.2%; IH: 41.9% vs 27.4%), metabolic (eg, obesity; narcolepsy: 30.2% vs 17.0%; IH: 35.1% vs 17.6%), and psychiatric (eg, mood disorders; narcolepsy: 45.3% vs 17.0%; IH: 46.5% vs 17.8%) comorbidities. Higher proportions of individuals with versus without narcolepsy had at least one claim for STD (n=351/2553; 13.7% vs n=404/5106; 7.9%) and LTD (n=16/2553; 0.6% vs n=28/5106; 0.5%), but similar WC claims (n=56/1812 vs n=111/3624; both 3.1%); a smaller proportion had WA claims (n=205/407; 50.4% vs n=509/814; 62.5%). Higher proportions of individuals with versus without IH had claims for STD (n=99/950; 10.4% vs n=151/1900; 7.9%), LTD (n=7/950; 0.7% vs n=8/1899; 0.4%), WC (n=23/597; 3.9% vs n=34/1194; 2.8%), and WA (n=140/179; 78.2% vs n=243/358; 67.9%).
Conclusions: Individuals with narcolepsy or IH had higher comorbidity burden and productivity losses. Findings underscore the high comorbidity burden in these populations and need for more holistic management of narcolepsy and IH to mitigate excess personal and societal impact
Short Description: This observational analysis of data from MarketScan® linked to the Health and Productivity Management (HPM) Database (01/2017‒12/2023) found that individuals with narcolepsy or idiopathic hypersomnia had a higher cardiovascular, metabolic, and psychiatric comorbidity burden and experienced greater productivity losses than individuals without narcolepsy or idiopathic hypersomnia. Findings underscore the need for improved management to mitigate excess personal and societal impact.
Name of Sponsoring Organization(s): Jazz Pharmaceuticals
Methods: MarketScan® linked to the Health and Productivity Management (HPM) Database (01/2017‒12/2023) identified individuals with narcolepsy or IH, matched to individuals without narcolepsy/IH. Clinical characteristics, short-term disability (STD), long-term disability (LTD), workplace absence (WA), and workers' compensation (WC) days missed from work were descriptively analyzed.
Results: Individuals with versus without narcolepsy or IH had a higher prevalence of cardiovascular (eg, hypertension; narcolepsy: 40.9% vs 26.2%; IH: 41.9% vs 27.4%), metabolic (eg, obesity; narcolepsy: 30.2% vs 17.0%; IH: 35.1% vs 17.6%), and psychiatric (eg, mood disorders; narcolepsy: 45.3% vs 17.0%; IH: 46.5% vs 17.8%) comorbidities. Higher proportions of individuals with versus without narcolepsy had at least one claim for STD (n=351/2553; 13.7% vs n=404/5106; 7.9%) and LTD (n=16/2553; 0.6% vs n=28/5106; 0.5%), but similar WC claims (n=56/1812 vs n=111/3624; both 3.1%); a smaller proportion had WA claims (n=205/407; 50.4% vs n=509/814; 62.5%). Higher proportions of individuals with versus without IH had claims for STD (n=99/950; 10.4% vs n=151/1900; 7.9%), LTD (n=7/950; 0.7% vs n=8/1899; 0.4%), WC (n=23/597; 3.9% vs n=34/1194; 2.8%), and WA (n=140/179; 78.2% vs n=243/358; 67.9%).
Conclusions: Individuals with narcolepsy or IH had higher comorbidity burden and productivity losses. Findings underscore the high comorbidity burden in these populations and need for more holistic management of narcolepsy and IH to mitigate excess personal and societal impact
Short Description: This observational analysis of data from MarketScan® linked to the Health and Productivity Management (HPM) Database (01/2017‒12/2023) found that individuals with narcolepsy or idiopathic hypersomnia had a higher cardiovascular, metabolic, and psychiatric comorbidity burden and experienced greater productivity losses than individuals without narcolepsy or idiopathic hypersomnia. Findings underscore the need for improved management to mitigate excess personal and societal impact.
Name of Sponsoring Organization(s): Jazz Pharmaceuticals
