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Depression

a young woman lies awake in bed
News
06/25/2026
Maria Mantas
A 3-year longitudinal study found that insomnia, excessive daytime sleepiness (EDS), and their co-occurrence were associated with increased risk of depression. 
A 3-year longitudinal study found that insomnia, excessive daytime sleepiness (EDS), and their co-occurrence were associated with increased risk of depression. 
A 3-year longitudinal study...
06/25/2026
Psych Congress Network
a woman scrolls on her phone while laying in bed
News
05/28/2026
Maria Mantas
A recent target trial emulation found no evidence of a causal relationship between frequent AI use and increased depressive symptoms among adults.
A recent target trial emulation found no evidence of a causal relationship between frequent AI use and increased depressive symptoms among adults.
A recent target trial emulation...
05/28/2026
Psych Congress Network
A lab tech handles psilocybin research
FDA Update
04/29/2026
Brionna Mendoza
Following an April 18 executive order, the US Food and Drug Administration (FDA) announced new regulatory actions to accelerate the development of psychedelic-assisted therapy for mental health conditions.
Following an April 18 executive order, the US Food and Drug Administration (FDA) announced new regulatory actions to accelerate the development of psychedelic-assisted therapy for mental health conditions.
Following an April 18 executive...
04/29/2026
Psych Congress Network
A patient receives psychedelic-assisted therapy
News
04/29/2026
Brionna Mendoza
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed...
04/29/2026
Psych Congress Network
a woman sits on a windowsill and looks out the window
Research Summary
03/27/2026
Brionna Mendoza
A phase 2b randomized clinical trial found that inhaled GH001, a synthetic formulation of mebufotenin, produced rapid antidepressant effects in adults with treatment-resistant depression (TRD). 
A phase 2b randomized clinical trial found that inhaled GH001, a synthetic formulation of mebufotenin, produced rapid antidepressant effects in adults with treatment-resistant depression (TRD). 
A phase 2b randomized clinical...
03/27/2026
Psych Congress Network
A woman lies on the couch holding an ice pack to her head
News
03/10/2026
Brionna Mendoza
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2...
03/10/2026
Psych Congress Network
Ketogenic diet for depression keto healthy fats
News
02/10/2026
Brionna Mendoza
A randomized clinical trial (RCT) assessed whether a keto diet could offer therapeutic benefit in adults with treatment-resistant depression (TRD) and found a modest improvement in depression measures versus control diet.
A randomized clinical trial (RCT) assessed whether a keto diet could offer therapeutic benefit in adults with treatment-resistant depression (TRD) and found a modest improvement in depression measures versus control diet.
A randomized clinical trial...
02/10/2026
Psych Congress Network
An orange prescription container with generic pills spilling out in front of it
News
02/03/2026
Brionna Mendoza
A large nationwide cohort study found no evidence that preinjury antidepressant use increases short-term mortality, need for emergency brain surgery, or length of hospitalization following TBI.
A large nationwide cohort study found no evidence that preinjury antidepressant use increases short-term mortality, need for emergency brain surgery, or length of hospitalization following TBI.
A large nationwide cohort study...
02/03/2026
Psych Congress Network
A frustrated man works on a laptop
News
01/23/2026
Maria Mantas
Daily or more frequent generative AI use was associated with higher depressive symptom scores on the PHQ-9 compared with nonuse in a large US survey.
Daily or more frequent generative AI use was associated with higher depressive symptom scores on the PHQ-9 compared with nonuse in a large US survey.
Daily or more frequent...
01/23/2026
Psych Congress Network
a depressed teen adolescent holds head in hands crying upset sad major depression
News
01/20/2026
Brionna Mendoza
A multicenter randomized clinical trial found that adding omega-3 fatty acid supplements to psychotherapy did not improve outcomes in children and adolescents with moderate-to-severe major depression.
A multicenter randomized clinical trial found that adding omega-3 fatty acid supplements to psychotherapy did not improve outcomes in children and adolescents with moderate-to-severe major depression.
A multicenter randomized...
01/20/2026
Psych Congress Network
woman experiencing depression
Research Summary
12/01/2025
Maria Mantas
A systematic review and meta-analysis of 7 clinical trials and 4 published protocol papers found that nitrous oxide (N2O) may offer rapid-acting benefit for the treatment of depression.
A systematic review and meta-analysis of 7 clinical trials and 4 published protocol papers found that nitrous oxide (N2O) may offer rapid-acting benefit for the treatment of depression.
A systematic review and...
12/01/2025
Psych Congress Network

News

a young woman lies awake in bed
News
06/25/2026
Maria Mantas
A 3-year longitudinal study found that insomnia, excessive daytime sleepiness (EDS), and their co-occurrence were associated with increased risk of depression. 
A 3-year longitudinal study found that insomnia, excessive daytime sleepiness (EDS), and their co-occurrence were associated with increased risk of depression. 
A 3-year longitudinal study...
06/25/2026
Psych Congress Network
a woman scrolls on her phone while laying in bed
News
05/28/2026
Maria Mantas
A recent target trial emulation found no evidence of a causal relationship between frequent AI use and increased depressive symptoms among adults.
A recent target trial emulation found no evidence of a causal relationship between frequent AI use and increased depressive symptoms among adults.
A recent target trial emulation...
05/28/2026
Psych Congress Network
A patient receives psychedelic-assisted therapy
News
04/29/2026
Brionna Mendoza
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed an executive order titled “Accelerating Medical Treatments for Serious Mental Illness,” which aims to expand psychedelic therapy access for significant mental health issues, such as suicidality, major...
President Donald J. Trump signed...
04/29/2026
Psych Congress Network
a woman sits on a windowsill and looks out the window
Research Summary
03/27/2026
Brionna Mendoza
A phase 2b randomized clinical trial found that inhaled GH001, a synthetic formulation of mebufotenin, produced rapid antidepressant effects in adults with treatment-resistant depression (TRD). 
A phase 2b randomized clinical trial found that inhaled GH001, a synthetic formulation of mebufotenin, produced rapid antidepressant effects in adults with treatment-resistant depression (TRD). 
A phase 2b randomized clinical...
03/27/2026
Psych Congress Network
A woman lies on the couch holding an ice pack to her head
News
03/10/2026
Brionna Mendoza
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2 times the risk for depression or anxiety compared to those without migraine, according to a large nationwide Swedish cohort study published in The Journal of Headache and Pain.
Patients with migraine are at 2...
03/10/2026
Psych Congress Network
Ketogenic diet for depression keto healthy fats
News
02/10/2026
Brionna Mendoza
A randomized clinical trial (RCT) assessed whether a keto diet could offer therapeutic benefit in adults with treatment-resistant depression (TRD) and found a modest improvement in depression measures versus control diet.
A randomized clinical trial (RCT) assessed whether a keto diet could offer therapeutic benefit in adults with treatment-resistant depression (TRD) and found a modest improvement in depression measures versus control diet.
A randomized clinical trial...
02/10/2026
Psych Congress Network
An orange prescription container with generic pills spilling out in front of it
News
02/03/2026
Brionna Mendoza
A large nationwide cohort study found no evidence that preinjury antidepressant use increases short-term mortality, need for emergency brain surgery, or length of hospitalization following TBI.
A large nationwide cohort study found no evidence that preinjury antidepressant use increases short-term mortality, need for emergency brain surgery, or length of hospitalization following TBI.
A large nationwide cohort study...
02/03/2026
Psych Congress Network
A frustrated man works on a laptop
News
01/23/2026
Maria Mantas
Daily or more frequent generative AI use was associated with higher depressive symptom scores on the PHQ-9 compared with nonuse in a large US survey.
Daily or more frequent generative AI use was associated with higher depressive symptom scores on the PHQ-9 compared with nonuse in a large US survey.
Daily or more frequent...
01/23/2026
Psych Congress Network
a depressed teen adolescent holds head in hands crying upset sad major depression
News
01/20/2026
Brionna Mendoza
A multicenter randomized clinical trial found that adding omega-3 fatty acid supplements to psychotherapy did not improve outcomes in children and adolescents with moderate-to-severe major depression.
A multicenter randomized clinical trial found that adding omega-3 fatty acid supplements to psychotherapy did not improve outcomes in children and adolescents with moderate-to-severe major depression.
A multicenter randomized...
01/20/2026
Psych Congress Network
open and spilled bottle of pills
News
11/03/2025
Maria Mantas
According to a recent systematic review and meta-analysis, the physiological effects of antidepressants vary greatly, particularly for cardiometabolic parameters.
According to a recent systematic review and meta-analysis, the physiological effects of antidepressants vary greatly, particularly for cardiometabolic parameters.
According to a recent systematic...
11/03/2025
Psych Congress Network
3D illustration of a brain in blue and white against a black background
Research Summary
10/21/2026
Brionna Mendoza
Home transcranial direct current stimulation paired with cognitive training delivered through a video game was feasible but offered no superior antidepressant benefit in a randomized clinical trial published in JAMA Network Open.
Home transcranial direct current stimulation paired with cognitive training delivered through a video game was feasible but offered no superior antidepressant benefit in a randomized clinical trial published in JAMA Network Open.
Home transcranial direct current...
10/21/2026
Psych Congress Network
a woman pours a pill from a pill bottle into her hand
Research Summary
10/15/2026
Maria Mantas
An individual participant data meta-analysis of 18 fixed-dose trials involving 7062 adults with acute schizophrenia found no evidence of sex differences in antipsychotic efficacy for overall symptom improvement.
An individual participant data meta-analysis of 18 fixed-dose trials involving 7062 adults with acute schizophrenia found no evidence of sex differences in antipsychotic efficacy for overall symptom improvement.
An individual participant data...
10/15/2026
Psych Congress Network
Head in profile with brain visible and target over brain
Research Summary
10/08/2026
Brionna Mendoza
A connectivity-guided approach to accelerated iTBS produced greater short-term reductions in depression severity than conventional scalp-based targeting.
A connectivity-guided approach to accelerated iTBS produced greater short-term reductions in depression severity than conventional scalp-based targeting.
A connectivity-guided approach...
10/08/2026
Psych Congress Network
an illustration of a man sitting on the ground holding his head with his profile and brain in the background
Research Summary
10/06/2026
Brionna Mendoza
Young people beginning antipsychotic treatment after first-episode psychosis had low medication adherence, according to a retrospective US cohort study published in JAMA Network Open.
Young people beginning antipsychotic treatment after first-episode psychosis had low medication adherence, according to a retrospective US cohort study published in JAMA Network Open.
Young people beginning...
10/06/2026
Psych Congress Network
A selection of ultraprocessed foods, including donuts, hamburgers, pizza, and fries.
News
09/25/2026
Brionna Mendoza
Reducing ultraprocessed food consumption was feasible and acceptable among adults with major depressive disorder (MDD) and was associated with lower depression and anxiety scores.
Reducing ultraprocessed food consumption was feasible and acceptable among adults with major depressive disorder (MDD) and was associated with lower depression and anxiety scores.
Reducing ultraprocessed food...
09/25/2026
Psych Congress Network
older woman with depression
Research Summary
09/23/2026
Maria Mantas
Vortioxetine was consistently associated with reduced depressive symptoms in older adults with MDD, while its effects on cognition were less consistent, according to a systematic review.
Vortioxetine was consistently associated with reduced depressive symptoms in older adults with MDD, while its effects on cognition were less consistent, according to a systematic review.
Vortioxetine was consistently...
09/23/2026
Psych Congress Network
a woman holds her hands as she looks at her computer screen
Conference Coverage
09/19/2026
Maria Mantas
Semaglutide initiation was associated with fewer clinician-recorded cognitive signs and symptoms among adults with psychiatric disorders, according to a poster presented at Psych Congress.
Semaglutide initiation was associated with fewer clinician-recorded cognitive signs and symptoms among adults with psychiatric disorders, according to a poster presented at Psych Congress.
Semaglutide initiation was...
09/19/2026
Psych Congress Network
a woman holds her head in her hands
Research Summary
09/01/2026
Maria Mantas
Negative expectations about the future were associated with differences in brain structure and a longer course of depressive illness among patients with MDD.
Negative expectations about the future were associated with differences in brain structure and a longer course of depressive illness among patients with MDD.
Negative expectations about the...
09/01/2026
Psych Congress Network
psilocybin
Research Summary
08/20/2026
Maria Mantas
Participants in Oregon’s state-regulated psilocybin program reported improvements in depression, anxiety, PTSD symptoms, mental well-being, and life satisfaction over 3 months.
Participants in Oregon’s state-regulated psilocybin program reported improvements in depression, anxiety, PTSD symptoms, mental well-being, and life satisfaction over 3 months.
Participants in Oregon’s...
08/20/2026
Psych Congress Network
A pregnant woman attends her doctor's appointment
News
08/18/2026
Brionna Mendoza
Treating MDD during pregnancy should be prioritized as part of maternal and fetal health care, argued the authors of a Special Communication published in JAMA Psychiatry.
Treating MDD during pregnancy should be prioritized as part of maternal and fetal health care, argued the authors of a Special Communication published in JAMA Psychiatry.
Treating MDD during pregnancy...
08/18/2026
Psych Congress Network

Quizzes

Pop quiz written on a blackboard with white chalk
Quiz
11/19/2025
Brionna Mendoza
Test your knowledge with this quiz!
Test your knowledge with this quiz!
Test your knowledge with this...
11/19/2025
Psych Congress Network
sticky note that reads "take the quiz"
Quiz
07/31/2025
Maria Mantas
Do you remember what the medication's guideline suggests?
Do you remember what the medication's guideline suggests?
Do you remember what the...
07/31/2025
Psych Congress Network
pencil erasers that spell out the word "quiz"
Quiz
07/14/2025
Maria Mantas
Do you remember the clinical guideline recommendations?
Do you remember the clinical guideline recommendations?
Do you remember the clinical...
07/14/2025
Psych Congress Network
sticky note that reads "take the quiz"
Quiz
05/23/2025
Maria Mantas
Do you remember the details of this study?
Do you remember the details of this study?
Do you remember the details of...
05/23/2025
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
12/23/2024
Test your knowledge with this quick quiz!
Test your knowledge with this quick quiz!
Test your knowledge with this...
12/23/2024
Psych Congress Network
Are men or women more affected by depressive episodes?
Quiz
12/17/2024
Pop quiz!
Pop quiz!
Pop quiz!
12/17/2024
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
03/04/2024
Test your clinical knowledge with this quick quiz!
Test your clinical knowledge with this quick quiz!
Test your clinical knowledge...
03/04/2024
Psych Congress Network
Three illustrated faces, one sad, one neutral, one happy.
Quiz
01/08/2024
Test your psychiatry knowledge with this quiz!
Test your psychiatry knowledge with this quiz!
Test your psychiatry knowledge...
01/08/2024
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
11/20/2023
Can you ace this psychiatry quiz?
Can you ace this psychiatry quiz?
Can you ace this psychiatry quiz?
11/20/2023
Psych Congress Network
Pencils spell out quiz.
Quiz
09/25/2023
Test your psychiatry knowledge with this quick quiz!
Test your psychiatry knowledge with this quick quiz!
Test your psychiatry knowledge...
09/25/2023
Psych Congress Network
Rakesh Jain, MD, MPH
Quiz
10/13/2026
Maria Mantas
According to an interview with Rakesh Jain, MD, MPH, what is a common mistake clinicians make when evaluating sleep complaints in patients with psychiatric disorders?
According to an interview with Rakesh Jain, MD, MPH, what is a common mistake clinicians make when evaluating sleep complaints in patients with psychiatric disorders?
According to an interview with...
10/13/2026
Psych Congress Network
illustration of a laptop screen displaying a test
Quiz
10/13/2026
Maria Mantas
Can you recall how biomarker-consistent antidepressant treatment compared to biomarker-inconsistent treatment?
Can you recall how biomarker-consistent antidepressant treatment compared to biomarker-inconsistent treatment?
Can you recall how...
10/13/2026
Psych Congress Network
pencil erasers that spell out the word "quiz"
Quiz
09/15/2026
Maria Mantas
Can you recall how iBTS compared to sham in addressing clinician-rated depressive symptoms among adults with MDD?
Can you recall how iBTS compared to sham in addressing clinician-rated depressive symptoms among adults with MDD?
Can you recall how iBTS compared...
09/15/2026
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
09/09/2026
Brionna Mendoza
Test your treatment knowledge with this quiz!
Test your treatment knowledge with this quiz!
Test your treatment knowledge...
09/09/2026
Psych Congress Network
Craig Chepke, MD, DFAPA
Quiz
09/03/2026
Maria Mantas
Test your knowledge of VMAT2 inhibitor dosing!
Test your knowledge of VMAT2 inhibitor dosing!
Test your knowledge of VMAT2...
09/03/2026
Psych Congress Network
Craig Chepke, MD, DFAPA
Quiz
09/03/2026
Maria Mantas
Test your knowledge of VMAT2 inhibitor dosing!
Test your knowledge of VMAT2 inhibitor dosing!
Test your knowledge of VMAT2...
09/03/2026
Psych Congress Network
an illustrated laptop screen displaying a quiz
Quiz
08/26/2026
Maria Mantas
Can you recall which drug demonstrated the highest efficacy as adjunctive therapy for major depressive disorder?
Can you recall which drug demonstrated the highest efficacy as adjunctive therapy for major depressive disorder?
Can you recall which drug...
08/26/2026
Psych Congress Network
pencil erasers that spell out the word "quiz"
Quiz
08/25/2026
Maria Mantas
What is the recommended dosage of citalopram for older patients? Test your prescribing knowledge with this quiz!
What is the recommended dosage of citalopram for older patients? Test your prescribing knowledge with this quiz!
What is the recommended dosage...
08/25/2026
Psych Congress Network
Chelsie Monroe Expert Insights Quiz
Expert Insights Quiz
08/03/2026
Maria Mantas
What key characteristics can help clinicians differentiate fatigue from excessive daytime sleepiness in clinical practice?
What key characteristics can help clinicians differentiate fatigue from excessive daytime sleepiness in clinical practice?
What key characteristics can...
08/03/2026
Psych Congress Network
a printed test, pencil, and clock on a desk
Quiz
07/23/2026
Maria Mantas
Can you recall what the APA guideline recommends? Test yourself with this quick quiz!
Can you recall what the APA guideline recommends? Test yourself with this quick quiz!
Can you recall what the APA...
07/23/2026
Psych Congress Network