Skip to main content

Major Depressive Disorder Topic Center

The US Food and Drug Administration headquarters sign.
FDA Alerts
01/21/2025
The US Food and Drug Administration (FDA) has approved a supplemental New Drug Application for esketamine CIII nasal spray (marketed as Spravato) as monotherapy for major depressive disorder (MDD) in adults who haven’t responded significantly...
The US Food and Drug Administration (FDA) has approved a supplemental New Drug Application for esketamine CIII nasal spray (marketed as Spravato) as monotherapy for major depressive disorder (MDD) in adults who haven’t responded significantly...
The US Food and Drug...
01/21/2025
Psych Congress Network
Quiz
Quiz
01/15/2025
According to a recent study published in the Journal of Affective Disorders, what percentage of people experienced hypomanic symptoms during a major depressive disorder (MDD) episode?
According to a recent study published in the Journal of Affective Disorders, what percentage of people experienced hypomanic symptoms during a major depressive disorder (MDD) episode?
According to a recent study...
01/15/2025
Psych Congress Network
Major Depressive Disorder MDD
News
01/03/2025
Common in patients with unipolar depression, hypomanic symptoms are associated with both treatment-resistant depression and reduced remission of suicidal thoughts, according to a study in the Journal of Affective Disorders.
Common in patients with unipolar depression, hypomanic symptoms are associated with both treatment-resistant depression and reduced remission of suicidal thoughts, according to a study in the Journal of Affective Disorders.
Common in patients with unipolar...
01/03/2025
Psych Congress Network
DSM-5
Quiz
12/13/2024
Quiz! What is the definition of remission in the context of major depressive disorder (MDD), according to the DSM-5-TR?
Quiz! What is the definition of remission in the context of major depressive disorder (MDD), according to the DSM-5-TR?
Quiz! What is the definition of...
12/13/2024
Psych Congress Network
depression stock photo
News
12/05/2024
A trio of newly identified mitophagy-related genes in astrocytes are promising biomarkers for diagnosing and treating MDD, according to a study in the Journal of Affective Disorders.
A trio of newly identified mitophagy-related genes in astrocytes are promising biomarkers for diagnosing and treating MDD, according to a study in the Journal of Affective Disorders.
A trio of newly identified...
12/05/2024
Psych Congress Network
quiz
Quiz
12/02/2024
Esketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, is indicated in conjunction with an oral antidepressant for the treatment of what? Take the quiz!
Esketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, is indicated in conjunction with an oral antidepressant for the treatment of what? Take the quiz!
Esketamine, a non-competitive...
12/02/2024
Psych Congress Network
Depression
News
11/22/2024
A study presented in a poster at Psych Congress 2024 in Boston, Massachusetts, aimed to understand the characteristics and treatment patterns of patients with MDD who experience prominent anhedonia compared to those who do not or who have low...
A study presented in a poster at Psych Congress 2024 in Boston, Massachusetts, aimed to understand the characteristics and treatment patterns of patients with MDD who experience prominent anhedonia compared to those who do not or who have low...
A study presented in a poster at...
11/22/2024
Psych Congress Network
quiz
Quiz
11/18/2024
The key barriers to a tardive dyskinesia diagnosis DID NOT include which of the following, according to data presented in a poster at Psych Congress 2024? Take the quiz now!
The key barriers to a tardive dyskinesia diagnosis DID NOT include which of the following, according to data presented in a poster at Psych Congress 2024? Take the quiz now!
The key barriers to a tardive...
11/18/2024
Psych Congress Network
An illustrated picture shows two cartoon doctors, one holding up a magnifying glass to a cartoon brain.
Conference Coverage
11/12/2024
Analysis of a long-term extension study of flexibly dosed esketamine nasal spray, in combination with an oral antidepressant, found durable long-term efficacy and safety of the treatment whether dosed weekly, every other week, or every 4...
Analysis of a long-term extension study of flexibly dosed esketamine nasal spray, in combination with an oral antidepressant, found durable long-term efficacy and safety of the treatment whether dosed weekly, every other week, or every 4...
Analysis of a long-term...
11/12/2024
Psychiatry & Behavioral Health
From Psychiatry & Behavioral Health
Patient survey
News
11/06/2024
Key barriers to tardive dyskinesia (TD) diagnosis include a lack of communication with the health care professional, lack of a physical exam, and low educational and socioeconomic status, according to a survey of adults with TD symptoms.
Key barriers to tardive dyskinesia (TD) diagnosis include a lack of communication with the health care professional, lack of a physical exam, and low educational and socioeconomic status, according to a survey of adults with TD symptoms.
Key barriers to tardive...
11/06/2024
Psych Congress Network

News

Major Depressive Disorder MDD
News
01/03/2025
Common in patients with unipolar depression, hypomanic symptoms are associated with both treatment-resistant depression and reduced remission of suicidal thoughts, according to a study in the Journal of Affective Disorders.
Common in patients with unipolar depression, hypomanic symptoms are associated with both treatment-resistant depression and reduced remission of suicidal thoughts, according to a study in the Journal of Affective Disorders.
Common in patients with unipolar...
01/03/2025
Psych Congress Network
depression stock photo
News
12/05/2024
A trio of newly identified mitophagy-related genes in astrocytes are promising biomarkers for diagnosing and treating MDD, according to a study in the Journal of Affective Disorders.
A trio of newly identified mitophagy-related genes in astrocytes are promising biomarkers for diagnosing and treating MDD, according to a study in the Journal of Affective Disorders.
A trio of newly identified...
12/05/2024
Psych Congress Network
Depression
News
11/22/2024
A study presented in a poster at Psych Congress 2024 in Boston, Massachusetts, aimed to understand the characteristics and treatment patterns of patients with MDD who experience prominent anhedonia compared to those who do not or who have low...
A study presented in a poster at Psych Congress 2024 in Boston, Massachusetts, aimed to understand the characteristics and treatment patterns of patients with MDD who experience prominent anhedonia compared to those who do not or who have low...
A study presented in a poster at...
11/22/2024
Psych Congress Network
Patient survey
News
11/06/2024
Key barriers to tardive dyskinesia (TD) diagnosis include a lack of communication with the health care professional, lack of a physical exam, and low educational and socioeconomic status, according to a survey of adults with TD symptoms.
Key barriers to tardive dyskinesia (TD) diagnosis include a lack of communication with the health care professional, lack of a physical exam, and low educational and socioeconomic status, according to a survey of adults with TD symptoms.
Key barriers to tardive...
11/06/2024
Psych Congress Network
depression stock photo
News
11/04/2024
Adjunctive treatment with the atypical antipsychotic lumateperone improved depressive symptoms and severity more than adjunctive placebo in patients with MDD with inadequate response to previous antidepressant therapy, according to a poster...
Adjunctive treatment with the atypical antipsychotic lumateperone improved depressive symptoms and severity more than adjunctive placebo in patients with MDD with inadequate response to previous antidepressant therapy, according to a poster...
Adjunctive treatment with the...
11/04/2024
Psych Congress Network
Psilocybin
News
10/08/2024
While intensive treatments with psilocybin and the serotonin reuptake inhibitor (SSRI) escitalopram were associated with long-term improvements in major depressive disorder (MDD) symptom severity, recent phase 2 double-blind, randomized,...
While intensive treatments with psilocybin and the serotonin reuptake inhibitor (SSRI) escitalopram were associated with long-term improvements in major depressive disorder (MDD) symptom severity, recent phase 2 double-blind, randomized,...
While intensive treatments with...
10/08/2024
Psych Congress Network
brain netw
News
09/05/2024
Patients with a particular cognitive biotype of treatment-resistant depression are more likely to experience improvement with TMS compared with other patients, study finds.
Patients with a particular cognitive biotype of treatment-resistant depression are more likely to experience improvement with TMS compared with other patients, study finds.
Patients with a particular...
09/05/2024
Psych Congress Network
Doctor and patient
News
08/01/2024
Antidepressant prescribing patterns and outcomes for patients with MDD vary significantly between prescriber groups, suggest study findings published in JAMA Psychiatry.
Antidepressant prescribing patterns and outcomes for patients with MDD vary significantly between prescriber groups, suggest study findings published in JAMA Psychiatry.
Antidepressant prescribing...
08/01/2024
Psych Congress Network
Combining TMS or tDCS With Certain Medications May Reduce MDD Symptoms
News
07/16/2024
Combining certain medications or psychotherapy with TMS or tDCS may decrease symptoms of MDD, though some limitations still exist, according to a review published in the Harvard Review of Psychiatry. 
Combining certain medications or psychotherapy with TMS or tDCS may decrease symptoms of MDD, though some limitations still exist, according to a review published in the Harvard Review of Psychiatry. 
Combining certain medications or...
07/16/2024
Psych Congress Network
ketamine brain image
News
05/14/2024
To address the challenges and “inadequate outcomes” with monoamine-based therapies, a Toronto-based research team investigated novel alternatives for TRD.
To address the challenges and “inadequate outcomes” with monoamine-based therapies, a Toronto-based research team investigated novel alternatives for TRD.
To address the challenges and...
05/14/2024
Psych Congress Network
Buprenorphine With Naloxone May Be Safe During Pregnancy for OUD Treatment
News
02/13/2025
When compared to buprenorphine alone, buprenorphine with naloxone during pregnancy may also be a safe treatment option for patients with opioid use disorder (OUD), according to results from a population-based cohort study published in JAMA. 
When compared to buprenorphine alone, buprenorphine with naloxone during pregnancy may also be a safe treatment option for patients with opioid use disorder (OUD), according to results from a population-based cohort study published in JAMA. 
When compared to buprenorphine...
02/13/2025
Psych Congress Network
A person holds a cannabis joint in their hands
News
02/11/2025
A lifetime history of heavy cannabis use in young adults was associated with lower brain activation during a working memory task, according to a study in JAMA Network Open
A lifetime history of heavy cannabis use in young adults was associated with lower brain activation during a working memory task, according to a study in JAMA Network Open
A lifetime history of heavy...
02/11/2025
Neurology
Methylphenidate Improved Driving Performance in Adults
News
02/10/2025
Methylphenidate improved driving performance in adults by reducing lane weaving and speed variation, according to results from a recent randomized controlled trial published in the Journal of Psychopharmacology. 
Methylphenidate improved driving performance in adults by reducing lane weaving and speed variation, according to results from a recent randomized controlled trial published in the Journal of Psychopharmacology. 
Methylphenidate improved driving...
02/10/2025
Psych Congress Network
News
02/07/2025
A recent study published in JAMA Network Open highlights the financial benefits of employer-sponsored behavioral health programs, demonstrating that these programs can result in significant net medical costs savings.
A recent study published in JAMA Network Open highlights the financial benefits of employer-sponsored behavioral health programs, demonstrating that these programs can result in significant net medical costs savings.
A recent study published in JAMA...
02/07/2025
First Report Managed Care
A woman holds her forehead looking stressed
News
02/03/2025
Elevated translocator protein (TSPO) binding, a marker of neuroinflammatory processes, was associated with more pronounced daily suicidal ideation and negative affect during real-world stress in patients with major depressive disorder (MDD).
Elevated translocator protein (TSPO) binding, a marker of neuroinflammatory processes, was associated with more pronounced daily suicidal ideation and negative affect during real-world stress in patients with major depressive disorder (MDD).
Elevated translocator protein...
02/03/2025
Psych Congress Network
Drug Overdose Deaths Overall Decrease from 2022 to 2023
News
01/31/2025
A recent report from the National Center for Health Statistics found many decreases in drug overdose deaths between 2022 and 2023, though certain subsections remained stable or increased year over year, according to the CDC and the National...
A recent report from the National Center for Health Statistics found many decreases in drug overdose deaths between 2022 and 2023, though certain subsections remained stable or increased year over year, according to the CDC and the National...
A recent report from the...
01/31/2025
Psych Congress Network
FDA building
News
01/28/2025
The FDA has approved a supplemental biologics license application for lecanemab-irmb (Leqembi, Eisai Co., Ltd.; Biogen Inc.), an intravenous treatment (IV) for early Alzheimer disease (AD).
The FDA has approved a supplemental biologics license application for lecanemab-irmb (Leqembi, Eisai Co., Ltd.; Biogen Inc.), an intravenous treatment (IV) for early Alzheimer disease (AD).
The FDA has approved a...
01/28/2025
Psych Congress Network
Brexpiprazole and Sertraline Combination Treatment Improves PTSD Symptoms
News
01/27/2025
Combining brexpiprazole and sertraline in treatment of post-traumatic stress disorder (PTSD) significantly improved PTSD symptoms when compared with sertraline and placebo treatment, according to results from a randomized clinical trial...
Combining brexpiprazole and sertraline in treatment of post-traumatic stress disorder (PTSD) significantly improved PTSD symptoms when compared with sertraline and placebo treatment, according to results from a randomized clinical trial...
Combining brexpiprazole and...
01/27/2025
Psych Congress Network
IED Linked With Multiple Psychiatric, Neurologic Comorbidities
News
01/24/2025
Intermittent explosive disorder (IED) was found to have many comorbidities, including substance use disorder, neurodegenerative diseases, sleep disorders, and many somatic diseases, according to a recent cohort study published in JAMA...
Intermittent explosive disorder (IED) was found to have many comorbidities, including substance use disorder, neurodegenerative diseases, sleep disorders, and many somatic diseases, according to a recent cohort study published in JAMA...
Intermittent explosive disorder...
01/24/2025
Psych Congress Network
ADHD Symptoms Associated With Lower Academic Performance in College Students
News
01/23/2025
Symptoms of attention-deficit/hyperactivity disorder (ADHD) were associated with a lower academic performance in college students, especially those with inattention symptoms, according to a recent systematic review published in the Journal of...
Symptoms of attention-deficit/hyperactivity disorder (ADHD) were associated with a lower academic performance in college students, especially those with inattention symptoms, according to a recent systematic review published in the Journal of...
Symptoms of...
01/23/2025
Psych Congress Network

Quizzes

Quiz
Quiz
01/15/2025
According to a recent study published in the Journal of Affective Disorders, what percentage of people experienced hypomanic symptoms during a major depressive disorder (MDD) episode?
According to a recent study published in the Journal of Affective Disorders, what percentage of people experienced hypomanic symptoms during a major depressive disorder (MDD) episode?
According to a recent study...
01/15/2025
Psych Congress Network
DSM-5
Quiz
12/13/2024
Quiz! What is the definition of remission in the context of major depressive disorder (MDD), according to the DSM-5-TR?
Quiz! What is the definition of remission in the context of major depressive disorder (MDD), according to the DSM-5-TR?
Quiz! What is the definition of...
12/13/2024
Psych Congress Network
quiz
Quiz
12/02/2024
Esketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, is indicated in conjunction with an oral antidepressant for the treatment of what? Take the quiz!
Esketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, is indicated in conjunction with an oral antidepressant for the treatment of what? Take the quiz!
Esketamine, a non-competitive...
12/02/2024
Psych Congress Network
quiz
Quiz
11/18/2024
The key barriers to a tardive dyskinesia diagnosis DID NOT include which of the following, according to data presented in a poster at Psych Congress 2024? Take the quiz now!
The key barriers to a tardive dyskinesia diagnosis DID NOT include which of the following, according to data presented in a poster at Psych Congress 2024? Take the quiz now!
The key barriers to a tardive...
11/18/2024
Psych Congress Network
pop quiz
Quiz
10/01/2024
During the induction and maintenance phases of esketamine treatment, how frequently should the medication be administered to treat TRD? Take the quiz to test your psychopharmacology knowledge.
During the induction and maintenance phases of esketamine treatment, how frequently should the medication be administered to treat TRD? Take the quiz to test your psychopharmacology knowledge.
During the induction and...
10/01/2024
Psych Congress Network
brain puzzle graphic
Quiz
09/09/2024
Patients with MDD who have undergone an adequate trial of optimized pharmacotherapy but only partial or no response should be reassessed for what? Take the quiz to find out!
Patients with MDD who have undergone an adequate trial of optimized pharmacotherapy but only partial or no response should be reassessed for what? Take the quiz to find out!
Patients with MDD who have...
09/09/2024
Psych Congress Network
quiz
Quiz
06/28/2024
Which factor is NOT a consideration when choosing an antidepressant medication according to the APA's major depressive disorder practice guidelines? Take the quiz to find out!
Which factor is NOT a consideration when choosing an antidepressant medication according to the APA's major depressive disorder practice guidelines? Take the quiz to find out!
Which factor is NOT a...
06/28/2024
Psych Congress Network
quiz
Quiz
03/18/2024
According to a recent study, which patient group is more likely to initially show less improvement in tinnitus symptoms when undergoing multilocus sequential rTMS therapy?
According to a recent study, which patient group is more likely to initially show less improvement in tinnitus symptoms when undergoing multilocus sequential rTMS therapy?
According to a recent study,...
03/18/2024
Psych Congress Network
How long must symptoms be present in order to diagnose MDD?
Quiz
12/13/2023
Test your diagnostic knowledge!
Test your diagnostic knowledge!
Test your diagnostic knowledge!
12/13/2023
Psych Congress Network
How many US Psychiatric Hospitals Provided Medications for OUD?
Quiz
02/06/2025
Do you remember the details of this study?
Do you remember the details of this study?
Do you remember the details of...
02/06/2025
Psych Congress Network
Four people ponder with question marks over their heads
Quiz
02/03/2025
Test your knowledge with this quick quiz!
Test your knowledge with this quick quiz!
Test your knowledge with this...
02/03/2025
Psych Congress Network
How many people with anxiety disorders receive treatment?
Quiz
01/28/2025
Test your statistical knowledge!
Test your statistical knowledge!
Test your statistical knowledge!
01/28/2025
Psych Congress Network
How can clinicians help patients with ADHD transition from adolescence to adulthood?
Quiz
01/22/2025
Do you remember this interview with Dr Wilens?
Do you remember this interview with Dr Wilens?
Do you remember this interview...
01/22/2025
Psych Congress Network
Three illustrated faces, one sad, one neutral, one happy, with a human hand picking up the happy face
Quiz
01/21/2025
Test your knowledge with this quiz!
Test your knowledge with this quiz!
Test your knowledge with this...
01/21/2025
Psych Congress Network
Quiz
Quiz
01/15/2025
According to a recent study published in the Journal of Affective Disorders, what percentage of people experienced hypomanic symptoms during a major depressive disorder (MDD) episode?
According to a recent study published in the Journal of Affective Disorders, what percentage of people experienced hypomanic symptoms during a major depressive disorder (MDD) episode?
According to a recent study...
01/15/2025
Psych Congress Network
Which U.S. region saw the most fentanyl pill seizures in 2023?
Quiz
01/15/2025
Do you remember the details of this study?
Do you remember the details of this study?
Do you remember the details of...
01/15/2025
Psych Congress Network
An illustration of a pencil marking answers on a quiz sheet.
Expert Insights Quiz
01/06/2025
Test your knowledge with this quiz!
Test your knowledge with this quiz!
Test your knowledge with this...
01/06/2025
Psych Congress Network
How long does worry need to be present in order to diagnose GAD?
Quiz
01/03/2025
Test your diagnostic knowledge!
Test your diagnostic knowledge!
Test your diagnostic knowledge!
01/03/2025
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
12/23/2024
Test your knowledge with this quick quiz!
Test your knowledge with this quick quiz!
Test your knowledge with this...
12/23/2024
Psych Congress Network