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Bipolar Disorders

A clinician fills out a form on a clipboard
News
RAP-219 Meets Key Endpoints in Acute Bipolar Mania Trial
10/26/2026
Brionna Mendoza
Investigational RAP-219 met the primary and secondary endpoints in a randomized, double-blind, placebo-controlled trial of adults experiencing acute bipolar mania, manufacturer Rapport Therapeutics announced on October 20, 2026.
Investigational RAP-219 met the primary and secondary endpoints in a randomized, double-blind, placebo-controlled trial of adults experiencing acute bipolar mania, manufacturer Rapport Therapeutics announced on October 20, 2026.
Investigational RAP-219 met the...
10/26/2026
Psych Congress Network
an illustration of a man sitting on the ground holding his head with his profile and brain in the background
Research Summary
Only 19.1% of First-Episode Psychosis Patients Adhere to Antipsychotics
10/06/2026
Brionna Mendoza
Young people beginning antipsychotic treatment after first-episode psychosis had low medication adherence, according to a retrospective US cohort study published in JAMA Network Open.
Young people beginning antipsychotic treatment after first-episode psychosis had low medication adherence, according to a retrospective US cohort study published in JAMA Network Open.
Young people beginning...
10/06/2026
Psych Congress Network
rows of pill bottles
Conference Coverage
Lumateperone Improves Acute Mania Symptoms, Trial Results Presented at Psych Congress
09/18/2026
Maria Mantas
Lumateperone significantly improved symptoms of acute mania in patients with bipolar I disorder with or without mixed features compared with placebo, according to data presented at Psych Congress.
Lumateperone significantly improved symptoms of acute mania in patients with bipolar I disorder with or without mixed features compared with placebo, according to data presented at Psych Congress.
Lumateperone significantly...
09/18/2026
Psych Congress Network
A baby resting on a mom's shoulder
News
Interpersonal Therapy Shows Promise for Perinatal Bipolar Disorder Management
05/07/2026
Maria Mantas
A pilot study found that an adapted version of Interpersonal and Social Rhythm Therapy (IPSRT) demonstrated both feasibility and high patient satisfaction across perinatal-specific challenges in pregnant women with bipolar disorder.
A pilot study found that an adapted version of Interpersonal and Social Rhythm Therapy (IPSRT) demonstrated both feasibility and high patient satisfaction across perinatal-specific challenges in pregnant women with bipolar disorder.
A pilot study found that an...
05/07/2026
Psych Congress Network
a printed test, pencil, and clock on a desk
Quiz
Mortality Risk in Bipolar II Disorder
04/30/2026
Maria Mantas
What was the association between all-cause mortality risk and bipolar II disorder? Test your knowledge with this quiz!
What was the association between all-cause mortality risk and bipolar II disorder? Test your knowledge with this quiz!
What was the association between...
04/30/2026
Psych Congress Network
A profile of a person split in half, one half teal and the other purple, with a swirl line over the head
News
Higher Risk of Premature Death Found in Bipolar II Disorder
04/07/2026
Brionna Mendoza
Bipolar II disorder (BD-II) is associated with significantly increased mortality, according to a large population-based cohort study published in JAMA Network Open.
Bipolar II disorder (BD-II) is associated with significantly increased mortality, according to a large population-based cohort study published in JAMA Network Open.
Bipolar II disorder (BD-II) is...
04/07/2026
Psych Congress Network
Food and Drug Administration building
News
FDA Approves Milsaperidone for Bipolar I and Schizophrenia in Adults
02/24/2026
Maria Mantas
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved...
02/24/2026
Psych Congress Network
Two pill bottles tipped over with pills on a table
News
Adolescent SSRI Use Not Causally Linked to Bipolar Disorder Risk, UK Registry Study Finds
01/06/2026
Sarah Fleming
New research published in BMJ Mental Health leveraged national United Kingdom (UK) health registry data to investigate whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescents with unipolar depression influences later...
New research published in BMJ Mental Health leveraged national United Kingdom (UK) health registry data to investigate whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescents with unipolar depression influences later...
New research published in BMJ...
01/06/2026
Psych Congress Network
artificial intelligence
News
AI-Based Prediction Tool Flags Psychotic and Bipolar Disorder Risk
01/05/2026
Maria Mantas
A large UK study reports that an artificial intelligence (AI)–enabled clinical prediction model may accurately identify individuals at risk of developing psychotic disorders or bipolar disorders.
A large UK study reports that an artificial intelligence (AI)–enabled clinical prediction model may accurately identify individuals at risk of developing psychotic disorders or bipolar disorders.
A large UK study reports that an...
01/05/2026
Psych Congress Network
Postpartum mother holding child
News
Postpartum Psychosis Should Be a Distinct Diagnosis, Experts Recommend
11/19/2025
Maria Mantas
An expert consensus panel is calling for postpartum psychosis (PP) to be recognized as a distinct diagnostic category in the DSM-5 and ICD-11.
An expert consensus panel is calling for postpartum psychosis (PP) to be recognized as a distinct diagnostic category in the DSM-5 and ICD-11.
An expert consensus panel is...
11/19/2025
Psych Congress Network
Covid-19
News
COVID-19 Post-Acute Sequelae More Likely in Patients With Serious Mental Illness
11/03/2025
Jolynn Tumolo
Patients with schizophrenia, bipolar disorder, or recurrent major depressive disorder have a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC) than patients without serious mental illness.
Patients with schizophrenia, bipolar disorder, or recurrent major depressive disorder have a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC) than patients without serious mental illness.
Patients with schizophrenia,...
11/03/2025
Psych Congress Network

News

A clinician fills out a form on a clipboard
News
RAP-219 Meets Key Endpoints in Acute Bipolar Mania Trial
10/26/2026
Brionna Mendoza
Investigational RAP-219 met the primary and secondary endpoints in a randomized, double-blind, placebo-controlled trial of adults experiencing acute bipolar mania, manufacturer Rapport Therapeutics announced on October 20, 2026.
Investigational RAP-219 met the primary and secondary endpoints in a randomized, double-blind, placebo-controlled trial of adults experiencing acute bipolar mania, manufacturer Rapport Therapeutics announced on October 20, 2026.
Investigational RAP-219 met the...
10/26/2026
Psych Congress Network
an illustration of a man sitting on the ground holding his head with his profile and brain in the background
Research Summary
Only 19.1% of First-Episode Psychosis Patients Adhere to Antipsychotics
10/06/2026
Brionna Mendoza
Young people beginning antipsychotic treatment after first-episode psychosis had low medication adherence, according to a retrospective US cohort study published in JAMA Network Open.
Young people beginning antipsychotic treatment after first-episode psychosis had low medication adherence, according to a retrospective US cohort study published in JAMA Network Open.
Young people beginning...
10/06/2026
Psych Congress Network
A profile of a person split in half, one half teal and the other purple, with a swirl line over the head
News
Higher Risk of Premature Death Found in Bipolar II Disorder
04/07/2026
Brionna Mendoza
Bipolar II disorder (BD-II) is associated with significantly increased mortality, according to a large population-based cohort study published in JAMA Network Open.
Bipolar II disorder (BD-II) is associated with significantly increased mortality, according to a large population-based cohort study published in JAMA Network Open.
Bipolar II disorder (BD-II) is...
04/07/2026
Psych Congress Network
Food and Drug Administration building
News
FDA Approves Milsaperidone for Bipolar I and Schizophrenia in Adults
02/24/2026
Maria Mantas
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved milsaperidone for the treatment of schizophrenia in adults and for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
The FDA has approved...
02/24/2026
Psych Congress Network
Two pill bottles tipped over with pills on a table
News
Adolescent SSRI Use Not Causally Linked to Bipolar Disorder Risk, UK Registry Study Finds
01/06/2026
Sarah Fleming
New research published in BMJ Mental Health leveraged national United Kingdom (UK) health registry data to investigate whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescents with unipolar depression influences later...
New research published in BMJ Mental Health leveraged national United Kingdom (UK) health registry data to investigate whether selective serotonin reuptake inhibitor (SSRI) treatment in adolescents with unipolar depression influences later...
New research published in BMJ...
01/06/2026
Psych Congress Network
artificial intelligence
News
AI-Based Prediction Tool Flags Psychotic and Bipolar Disorder Risk
01/05/2026
Maria Mantas
A large UK study reports that an artificial intelligence (AI)–enabled clinical prediction model may accurately identify individuals at risk of developing psychotic disorders or bipolar disorders.
A large UK study reports that an artificial intelligence (AI)–enabled clinical prediction model may accurately identify individuals at risk of developing psychotic disorders or bipolar disorders.
A large UK study reports that an...
01/05/2026
Psych Congress Network
Postpartum mother holding child
News
Postpartum Psychosis Should Be a Distinct Diagnosis, Experts Recommend
11/19/2025
Maria Mantas
An expert consensus panel is calling for postpartum psychosis (PP) to be recognized as a distinct diagnostic category in the DSM-5 and ICD-11.
An expert consensus panel is calling for postpartum psychosis (PP) to be recognized as a distinct diagnostic category in the DSM-5 and ICD-11.
An expert consensus panel is...
11/19/2025
Psych Congress Network
Covid-19
News
COVID-19 Post-Acute Sequelae More Likely in Patients With Serious Mental Illness
11/03/2025
Jolynn Tumolo
Patients with schizophrenia, bipolar disorder, or recurrent major depressive disorder have a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC) than patients without serious mental illness.
Patients with schizophrenia, bipolar disorder, or recurrent major depressive disorder have a higher risk of developing postacute sequelae of SARS-CoV-2 (PASC) than patients without serious mental illness.
Patients with schizophrenia,...
11/03/2025
Psych Congress Network
US FDA sign
News
FDA OKs Once Monthly Subcutaneous Risperidone for Bipolar I Disorder
10/20/2025
Brionna Mendoza
The US Food and Drug Administration (FDA) has approved risperidone (Uzedy) as a once-monthly extended-release injectable suspension for the treatment of bipolar I disorder (BD-I).
The US Food and Drug Administration (FDA) has approved risperidone (Uzedy) as a once-monthly extended-release injectable suspension for the treatment of bipolar I disorder (BD-I).
The US Food and Drug...
10/20/2025
Psych Congress Network
stethoscope, pills, and a brain
News
Stimulant Treatment for ADHD Associated With Psychosis and BD
09/25/2025
Maria Mantas
Stimulant use for the treatment of attention-deficit/hyperactivity disorder (ADHD) was associated with higher occurrence of psychotic symptoms, psychotic disorders, and bipolar disorder (BD), according to a systematic review.
Stimulant use for the treatment of attention-deficit/hyperactivity disorder (ADHD) was associated with higher occurrence of psychotic symptoms, psychotic disorders, and bipolar disorder (BD), according to a systematic review.
Stimulant use for the treatment...
09/25/2025
Psych Congress Network
A clinician fills out a form on a clipboard
News
RAP-219 Meets Key Endpoints in Acute Bipolar Mania Trial
10/26/2026
Brionna Mendoza
Investigational RAP-219 met the primary and secondary endpoints in a randomized, double-blind, placebo-controlled trial of adults experiencing acute bipolar mania, manufacturer Rapport Therapeutics announced on October 20, 2026.
Investigational RAP-219 met the primary and secondary endpoints in a randomized, double-blind, placebo-controlled trial of adults experiencing acute bipolar mania, manufacturer Rapport Therapeutics announced on October 20, 2026.
Investigational RAP-219 met the...
10/26/2026
Psych Congress Network
3D illustration of a brain in blue and white against a black background
Research Summary
Home Depression Protocol Proves Feasible but Shows No Added Benefit
10/21/2026
Brionna Mendoza
Home transcranial direct current stimulation paired with cognitive training delivered through a video game was feasible but offered no superior antidepressant benefit in a randomized clinical trial published in JAMA Network Open.
Home transcranial direct current stimulation paired with cognitive training delivered through a video game was feasible but offered no superior antidepressant benefit in a randomized clinical trial published in JAMA Network Open.
Home transcranial direct current...
10/21/2026
Psych Congress Network
a woman pours a pill from a pill bottle into her hand
Research Summary
Meta-Analysis Finds No Clear Sex Differences in Antipsychotic Efficacy
10/15/2026
Maria Mantas
An individual participant data meta-analysis of 18 fixed-dose trials involving 7062 adults with acute schizophrenia found no evidence of sex differences in antipsychotic efficacy for overall symptom improvement.
An individual participant data meta-analysis of 18 fixed-dose trials involving 7062 adults with acute schizophrenia found no evidence of sex differences in antipsychotic efficacy for overall symptom improvement.
An individual participant data...
10/15/2026
Psych Congress Network
Head in profile with brain visible and target over brain
Research Summary
Structural Connectivity–Guided iTBS Improves Early Depression Outcomes
10/08/2026
Brionna Mendoza
A connectivity-guided approach to accelerated iTBS produced greater short-term reductions in depression severity than conventional scalp-based targeting.
A connectivity-guided approach to accelerated iTBS produced greater short-term reductions in depression severity than conventional scalp-based targeting.
A connectivity-guided approach...
10/08/2026
Psych Congress Network
an illustration of a man sitting on the ground holding his head with his profile and brain in the background
Research Summary
Only 19.1% of First-Episode Psychosis Patients Adhere to Antipsychotics
10/06/2026
Brionna Mendoza
Young people beginning antipsychotic treatment after first-episode psychosis had low medication adherence, according to a retrospective US cohort study published in JAMA Network Open.
Young people beginning antipsychotic treatment after first-episode psychosis had low medication adherence, according to a retrospective US cohort study published in JAMA Network Open.
Young people beginning...
10/06/2026
Psych Congress Network
A selection of ultraprocessed foods, including donuts, hamburgers, pizza, and fries.
News
Low-Ultraprocessed-Food Diet Linked to Lower Depression Scores
09/25/2026
Brionna Mendoza
Reducing ultraprocessed food consumption was feasible and acceptable among adults with major depressive disorder (MDD) and was associated with lower depression and anxiety scores.
Reducing ultraprocessed food consumption was feasible and acceptable among adults with major depressive disorder (MDD) and was associated with lower depression and anxiety scores.
Reducing ultraprocessed food...
09/25/2026
Psych Congress Network
older woman with depression
Research Summary
Vortioxetine Improves Depression, Shows Mixed Cognitive Effects in Older Adults
09/23/2026
Maria Mantas
Vortioxetine was consistently associated with reduced depressive symptoms in older adults with MDD, while its effects on cognition were less consistent, according to a systematic review.
Vortioxetine was consistently associated with reduced depressive symptoms in older adults with MDD, while its effects on cognition were less consistent, according to a systematic review.
Vortioxetine was consistently...
09/23/2026
Psych Congress Network
a woman holds her hands as she looks at her computer screen
Conference Coverage
Semaglutide Linked to Fewer Cognitive Symptoms in Psychiatric Disorders
09/19/2026
Maria Mantas
Semaglutide initiation was associated with fewer clinician-recorded cognitive signs and symptoms among adults with psychiatric disorders, according to a poster presented at Psych Congress.
Semaglutide initiation was associated with fewer clinician-recorded cognitive signs and symptoms among adults with psychiatric disorders, according to a poster presented at Psych Congress.
Semaglutide initiation was...
09/19/2026
Psych Congress Network
a woman holds her head in her hands
Research Summary
Negative Expectations Linked to Brain Structure, Depression Course in MDD
09/01/2026
Maria Mantas
Negative expectations about the future were associated with differences in brain structure and a longer course of depressive illness among patients with MDD.
Negative expectations about the future were associated with differences in brain structure and a longer course of depressive illness among patients with MDD.
Negative expectations about the...
09/01/2026
Psych Congress Network
psilocybin
Research Summary
Oregon Psilocybin Program Shows Mental Health Improvements, Few Serious Reactions
08/20/2026
Maria Mantas
Participants in Oregon’s state-regulated psilocybin program reported improvements in depression, anxiety, PTSD symptoms, mental well-being, and life satisfaction over 3 months.
Participants in Oregon’s state-regulated psilocybin program reported improvements in depression, anxiety, PTSD symptoms, mental well-being, and life satisfaction over 3 months.
Participants in Oregon’s...
08/20/2026
Psych Congress Network

Quizzes

a printed test, pencil, and clock on a desk
Quiz
Mortality Risk in Bipolar II Disorder
04/30/2026
Maria Mantas
What was the association between all-cause mortality risk and bipolar II disorder? Test your knowledge with this quiz!
What was the association between all-cause mortality risk and bipolar II disorder? Test your knowledge with this quiz!
What was the association between...
04/30/2026
Psych Congress Network
Death risk increased by how much with a bipolar disorder diagnosis?
Quiz
Death risk increased by how much with a bipolar disorder diagnosis?
02/26/2024
Do you remember the details of this study?
Do you remember the details of this study?
Do you remember the details of...
02/26/2024
Psych Congress Network
polygenic risk scores
Quiz
Is there an association between hospitalization frequency and polygenic risk score?
10/06/2022
Take the quiz to test your clinical knowledge!
Take the quiz to test your clinical knowledge!
Take the quiz to test your...
10/06/2022
Psych Congress Network
COVID-19 risk.
Quiz
Antipsychotic Use and COVID-19 Risk in Patients with BD and SMI
06/15/2022
How does antipsychotic use affect COVID-19 risk? Take the quiz now to test your knowledge!
How does antipsychotic use affect COVID-19 risk? Take the quiz now to test your knowledge!
How does antipsychotic use...
06/15/2022
Psych Congress Network
Quiz
Challenges for Patients With Bipolar Disorder
01/11/2022
According to a recent survey, which of the following concerns did patients with bipolar-I disorder report?
According to a recent survey, which of the following concerns did patients with bipolar-I disorder report?
According to a recent survey,...
01/11/2022
Psych Congress Network
Rakesh Jain, MD, MPH
Quiz
Common Missteps in Sleep Care
10/13/2026
Maria Mantas
According to an interview with Rakesh Jain, MD, MPH, what is a common mistake clinicians make when evaluating sleep complaints in patients with psychiatric disorders?
According to an interview with Rakesh Jain, MD, MPH, what is a common mistake clinicians make when evaluating sleep complaints in patients with psychiatric disorders?
According to an interview with...
10/13/2026
Psych Congress Network
illustration of a laptop screen displaying a test
Quiz
Biomarker-Consistent Antidepressant Selection
10/13/2026
Maria Mantas
Can you recall how biomarker-consistent antidepressant treatment compared to biomarker-inconsistent treatment?
Can you recall how biomarker-consistent antidepressant treatment compared to biomarker-inconsistent treatment?
Can you recall how...
10/13/2026
Psych Congress Network
pencil erasers that spell out the word "quiz"
Quiz
iTBS Outcomes in MDD
09/15/2026
Maria Mantas
Can you recall how iBTS compared to sham in addressing clinician-rated depressive symptoms among adults with MDD?
Can you recall how iBTS compared to sham in addressing clinician-rated depressive symptoms among adults with MDD?
Can you recall how iBTS compared...
09/15/2026
Psych Congress Network
Pop quiz written on a blackboard with white chalk
Quiz
rTMS Function in MDD Treatment
09/09/2026
Brionna Mendoza
Test your treatment knowledge with this quiz!
Test your treatment knowledge with this quiz!
Test your treatment knowledge...
09/09/2026
Psych Congress Network
Craig Chepke, MD, DFAPA
Quiz
Assessing VMAT2 Inhibitor Response
09/03/2026
Maria Mantas
Test your knowledge of VMAT2 inhibitor dosing!
Test your knowledge of VMAT2 inhibitor dosing!
Test your knowledge of VMAT2...
09/03/2026
Psych Congress Network
Craig Chepke, MD, DFAPA
Quiz
Assessing VMAT2 Inhibitor Response
09/03/2026
Maria Mantas
Test your knowledge of VMAT2 inhibitor dosing!
Test your knowledge of VMAT2 inhibitor dosing!
Test your knowledge of VMAT2...
09/03/2026
Psych Congress Network
an illustrated laptop screen displaying a quiz
Quiz
Adjunctive Treatment Efficacy in MDD
08/26/2026
Maria Mantas
Can you recall which drug demonstrated the highest efficacy as adjunctive therapy for major depressive disorder?
Can you recall which drug demonstrated the highest efficacy as adjunctive therapy for major depressive disorder?
Can you recall which drug...
08/26/2026
Psych Congress Network
pencil erasers that spell out the word "quiz"
Quiz
Citalopram Dosing in Older Adults
08/25/2026
Maria Mantas
What is the recommended dosage of citalopram for older patients? Test your prescribing knowledge with this quiz!
What is the recommended dosage of citalopram for older patients? Test your prescribing knowledge with this quiz!
What is the recommended dosage...
08/25/2026
Psych Congress Network
Chelsie Monroe Expert Insights Quiz
Expert Insights Quiz
Distinguishing EDS From Fatigue
08/03/2026
Maria Mantas
What key characteristics can help clinicians differentiate fatigue from excessive daytime sleepiness in clinical practice?
What key characteristics can help clinicians differentiate fatigue from excessive daytime sleepiness in clinical practice?
What key characteristics can...
08/03/2026
Psych Congress Network
a printed test, pencil, and clock on a desk
Quiz
Pharmacologic Treatment for Adolescent MDD
07/23/2026
Maria Mantas
Can you recall what the APA guideline recommends? Test yourself with this quick quiz!
Can you recall what the APA guideline recommends? Test yourself with this quick quiz!
Can you recall what the APA...
07/23/2026
Psych Congress Network

NEW FROM THE NP INSTITUTE ONLINE LEARNING HUB

andrew and julie
Rapid Refresh
Navigating Bipolar Disorder Treatment: Exploring the Role of Second-Generation Antipsychotics
04/11/2024

Featuring Andrew Penn, MS, PMHNP, and Julie Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN

Featuring Andrew Penn, MS, PMHNP...
Andrew Penn, MS, PMHNP, and Julie Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN, explore the nuanced role of second-generation antipsychotics in bipolar disorder treatment. They discuss the complexities of managing mania and depression phases and...
Andrew Penn, MS, PMHNP, and Julie Carbray, PhD, FPMHNP-BC, PMHCNS-BC, APRN, explore the nuanced role of second-generation antipsychotics in bipolar disorder treatment. They discuss the complexities of managing mania and depression phases and...
Andrew Penn, MS, PMHNP, and...
04/11/2024
Psych Congress NP Institute
Amber Hoberg
Rapid Refresh
Long-Acting Injectables for Adolescents With Schizophrenia and Schizoaffective Disorder
04/10/2024
Amber Hoberg, MSN, APRN, PMHNP-BC
Amber Hoberg, PMHNP-BC, navigates the complexities of adolescent psychosis treatment, exploring the potential benefits and considerations of LAIs for schizophrenia and schizoaffective disorder, while emphasizing evidence-based practice for...
Amber Hoberg, PMHNP-BC, navigates the complexities of adolescent psychosis treatment, exploring the potential benefits and considerations of LAIs for schizophrenia and schizoaffective disorder, while emphasizing evidence-based practice for...
Amber Hoberg, PMHNP-BC,...
04/10/2024
Psych Congress NP Institute
Hoberg and Matthews
Clinical Insights
Tolerability Testing in Long-Acting Injectable Prescriptions
04/03/2024
Desiree Matthews, PHMNP-BC; Amber Hoberg, MSN, APRN, PMHNP-BC
Do clinicians need to test for tolerability before prescribing a long-acting injectable (LAI)? Desiree Matthews, PMHNP-BC, and Amber Hoberg, MSN, APRN, PMHNP-BC, offer their clinical insight.
Do clinicians need to test for tolerability before prescribing a long-acting injectable (LAI)? Desiree Matthews, PMHNP-BC, and Amber Hoberg, MSN, APRN, PMHNP-BC, offer their clinical insight.
Do clinicians need to test for...
04/03/2024
Psych Congress NP Institute

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