Poster
128
(#128) Impact of Sleep Inertia on Cognition in People With Idiopathic Hypersomnia
Psych Congress 2025
Abstract: Background:
This analysis aimed to describe the impact of sleep inertia (SI) on cognition in people with idiopathic hypersomnia (IH).
Methods:
Commercially insured adults diagnosed with IH were identified in the Optum Research Database (1/1/2019-5/31/2024). Eligible individuals were mailed a survey of validated assessments (eg, Sleep Inertia Questionnaire [SIQ; score range, 21-105], Idiopathic Hypersomnia Severity Scale [IHSS]) and de novo questions assessing Sl-related symptom frequency and quality of life. Descriptive analyses were conducted.
Results:
Overall, 242 participants returned surveys (18.9% response rate). Mean (SD) participant age was 41.9 (13.1) years; 78.9% of participants were female. Most participants reported SI (SIQ score ≥42; n=220; 90.9%), with 109 (49.5%) reporting severe or very severe SI (SIQ score ≥73). On the IHSS, 47.1% of all participants and 72.5% of participants with SIQ scores ≥73 reported that hypersomnolence significantly or very significantly impacted intellectual functioning. Many participants reported that SI had a moderate or high impact on concentration (69.3%) and school/work performance (63.4%), and that they often or always experienced brain fog (61.2%) and grogginess/fogginess on waking (60.4%). Every participant with very severe SI (SIQ score ≥85; n=54; 22.3%) reported that, on waking, they thought more slowly; had difficulty getting their thoughts together; and noticed their minds felt groggy, fuzzy, or hazy; over half reported that symptoms persisted for >1 hour after waking.
Conclusions:
Many participants reported that SI negatively impacted their cognition, underscoring the need for clinical vigilance of SI when diagnosing and treating people with IH.
Short Description: This analysis reports on the impact of sleep inertia on cognition in people diagnosed with idiopathic hypersomnia. In this cross-sectional survey, many participants, especially those with very severe or severe sleep inertia, reported that sleep inertia had a high impact on multiple cognitive domains, including their intellectual functioning, concentration, and experience waking up.
Name of Sponsoring Organization(s): Jazz Pharmaceuticals
This analysis aimed to describe the impact of sleep inertia (SI) on cognition in people with idiopathic hypersomnia (IH).
Methods:
Commercially insured adults diagnosed with IH were identified in the Optum Research Database (1/1/2019-5/31/2024). Eligible individuals were mailed a survey of validated assessments (eg, Sleep Inertia Questionnaire [SIQ; score range, 21-105], Idiopathic Hypersomnia Severity Scale [IHSS]) and de novo questions assessing Sl-related symptom frequency and quality of life. Descriptive analyses were conducted.
Results:
Overall, 242 participants returned surveys (18.9% response rate). Mean (SD) participant age was 41.9 (13.1) years; 78.9% of participants were female. Most participants reported SI (SIQ score ≥42; n=220; 90.9%), with 109 (49.5%) reporting severe or very severe SI (SIQ score ≥73). On the IHSS, 47.1% of all participants and 72.5% of participants with SIQ scores ≥73 reported that hypersomnolence significantly or very significantly impacted intellectual functioning. Many participants reported that SI had a moderate or high impact on concentration (69.3%) and school/work performance (63.4%), and that they often or always experienced brain fog (61.2%) and grogginess/fogginess on waking (60.4%). Every participant with very severe SI (SIQ score ≥85; n=54; 22.3%) reported that, on waking, they thought more slowly; had difficulty getting their thoughts together; and noticed their minds felt groggy, fuzzy, or hazy; over half reported that symptoms persisted for >1 hour after waking.
Conclusions:
Many participants reported that SI negatively impacted their cognition, underscoring the need for clinical vigilance of SI when diagnosing and treating people with IH.
Short Description: This analysis reports on the impact of sleep inertia on cognition in people diagnosed with idiopathic hypersomnia. In this cross-sectional survey, many participants, especially those with very severe or severe sleep inertia, reported that sleep inertia had a high impact on multiple cognitive domains, including their intellectual functioning, concentration, and experience waking up.
Name of Sponsoring Organization(s): Jazz Pharmaceuticals
