Poster
153
(#153) Anatomical Distribution of Involuntary Movements and Clinician-Reported Impact of Tardive Dyskinesia: A Real-World Analysis of the IMPACT-TD Registry
Psych Congress 2025
Abstract: Background: To examine the relationship between the multidimensional impact of tardive dyskinesia (TD) on daily functioning and the anatomical distribution and severity of TD-associated movements.
Methods: Included IMPACT-TD Registry participants, aged ≥18 years, had a score of ≥2 on ≥1 item of the Abnormal Involuntary Movement Scale (AIMS) and probable TD with no active vesicular monoamine transporter 2 inhibitor treatment at enrollment. Clinicians rated TD impact in 4 life domains (social, psychological/psychiatric, physical, and vocational/educational/recreational) using the IMPACT-TD ClinRO scale (4-point Likert scale, highest domain score=global score). AIMS component scores (muscles of facial expression, jaw, lips/perioral area, tongue, upper extremities, lower extremities, and trunk) and their relationship with moderate/severe ClinRO domain scores were evaluated.
Results: Across all ClinRO domains, individuals who experienced moderate/severe impact of TD had median AIMS component scores of 2 (muscles of facial expression, upper extremities), 1 (tongue, lower extremities), and 0 (trunk). AIMS component scores in the lips/perioral area and in the jaw varied by ClinRO domain (social, physical: median=2; psychological/psychiatric, vocational/educational/recreational: median=1). Among individuals with AIMS 1/2 in any body region, 71-81% experienced moderate/severe global TD impact, with highest impact seen in the psychological domain. Among individuals with AIMS 3/4 in either muscles of facial expression, lower extremities, or trunk, ≥80% experienced moderate/severe impact of TD in each ClinRO domain.
Conclusions: Even with AIMS component scores 1/2, individuals experienced moderate/severe multidimensional impact of TD.
Short Description: Individuals can experience moderate/severe multidimensional impact of TD even when individual AIMS component scores are mild in severity. Pronounced movements involving the muscles of facial expression, lower extremities, and trunk are most consistently linked to moderate/severe TD-related impact across multiple functional domains. These findings underscore the need for clinicians to assess TD functional impact in addition to assessing movement severity.
Name of Sponsoring Organization(s): Teva Branded Pharmaceutical Products R&D LLC
Methods: Included IMPACT-TD Registry participants, aged ≥18 years, had a score of ≥2 on ≥1 item of the Abnormal Involuntary Movement Scale (AIMS) and probable TD with no active vesicular monoamine transporter 2 inhibitor treatment at enrollment. Clinicians rated TD impact in 4 life domains (social, psychological/psychiatric, physical, and vocational/educational/recreational) using the IMPACT-TD ClinRO scale (4-point Likert scale, highest domain score=global score). AIMS component scores (muscles of facial expression, jaw, lips/perioral area, tongue, upper extremities, lower extremities, and trunk) and their relationship with moderate/severe ClinRO domain scores were evaluated.
Results: Across all ClinRO domains, individuals who experienced moderate/severe impact of TD had median AIMS component scores of 2 (muscles of facial expression, upper extremities), 1 (tongue, lower extremities), and 0 (trunk). AIMS component scores in the lips/perioral area and in the jaw varied by ClinRO domain (social, physical: median=2; psychological/psychiatric, vocational/educational/recreational: median=1). Among individuals with AIMS 1/2 in any body region, 71-81% experienced moderate/severe global TD impact, with highest impact seen in the psychological domain. Among individuals with AIMS 3/4 in either muscles of facial expression, lower extremities, or trunk, ≥80% experienced moderate/severe impact of TD in each ClinRO domain.
Conclusions: Even with AIMS component scores 1/2, individuals experienced moderate/severe multidimensional impact of TD.
Short Description: Individuals can experience moderate/severe multidimensional impact of TD even when individual AIMS component scores are mild in severity. Pronounced movements involving the muscles of facial expression, lower extremities, and trunk are most consistently linked to moderate/severe TD-related impact across multiple functional domains. These findings underscore the need for clinicians to assess TD functional impact in addition to assessing movement severity.
Name of Sponsoring Organization(s): Teva Branded Pharmaceutical Products R&D LLC
