Poster
154
(#154) Anatomical Distribution of Involuntary Movements and Formal Diagnosis of Tardive Dyskinesia: A Real-World Analysis of the IMPACT-TD Registry
Psych Congress 2025
Abstract: Background: To identify patterns that may affect tardive dyskinesia (TD) diagnosis, the anatomical distribution of abnormal movements was compared in IMPACT-TD Registry participants with or without formal TD diagnosis.
Methods: Included participants were aged ≥18 years with a score of ≥2 on ≥1 item of the Abnormal Involuntary Movement Scale (AIMS) and probable TD with no active vesicular monoamine transporter 2 inhibitor treatment at enrollment. AIMS component scores (muscles of facial expression, jaw, lips/perioral area, tongue, upper extremities, lower extremities, and trunk) and Schooler-Kane criteria for TD (AIMS score of ≥3 in ≥1 body region or ≥2 in ≥2 body regions) were stratified by AIMS total motor score (1-6, 7-14, ≥15) and by clinician-reported formal TD diagnosis.
Results: Among 438 participants with AIMS baseline data, 73.7% overall and 42.3% with total motor AIMS scores 1-6 (lowest severity) met Schooler-Kane criteria. The proportion of participants with AIMS ≥2 was highest in upper extremities (50.6% of participants), muscles of facial expression (48.2%), lips and perioral area (45.2%), jaw (43.7%), and tongue (39.8%), and lowest in lower extremities (32.1%) and trunk (19.5%). A greater proportion of those with formal diagnosis (147/177, 83.1%) versus no formal diagnosis (176/261, 67.4%) met Schooler-Kane criteria. A higher proportion of individuals with formal TD diagnosis had AIMS ≥2 in lips/perioral area, jaw, lower extremity, and trunk regions than in those with no formal diagnosis.
Conclusions: Abnormal movements in lips/perioral area, jaw, lower extremities, and trunk were more common in those with formal TD diagnosis.
Short Description: In this real-world study, the proportion of IMPACT-TD Registry participants who experienced abnormal movements (AIMS ≥2) was highest in upper extremities, muscles of facial expression, lips and perioral area, jaw, and tongue, and lowest in lower extremities and trunk regions. Among individuals with no formal TD diagnosis, 67.4% met Schooler-Kane criteria. Abnormal movements in the lips/perioral area, jaw, lower extremities, and trunk were more common in those with formal TD diagnosis versus no diagnosis.
Name of Sponsoring Organization(s): Teva Branded Pharmaceutical Products R&D LLC
Methods: Included participants were aged ≥18 years with a score of ≥2 on ≥1 item of the Abnormal Involuntary Movement Scale (AIMS) and probable TD with no active vesicular monoamine transporter 2 inhibitor treatment at enrollment. AIMS component scores (muscles of facial expression, jaw, lips/perioral area, tongue, upper extremities, lower extremities, and trunk) and Schooler-Kane criteria for TD (AIMS score of ≥3 in ≥1 body region or ≥2 in ≥2 body regions) were stratified by AIMS total motor score (1-6, 7-14, ≥15) and by clinician-reported formal TD diagnosis.
Results: Among 438 participants with AIMS baseline data, 73.7% overall and 42.3% with total motor AIMS scores 1-6 (lowest severity) met Schooler-Kane criteria. The proportion of participants with AIMS ≥2 was highest in upper extremities (50.6% of participants), muscles of facial expression (48.2%), lips and perioral area (45.2%), jaw (43.7%), and tongue (39.8%), and lowest in lower extremities (32.1%) and trunk (19.5%). A greater proportion of those with formal diagnosis (147/177, 83.1%) versus no formal diagnosis (176/261, 67.4%) met Schooler-Kane criteria. A higher proportion of individuals with formal TD diagnosis had AIMS ≥2 in lips/perioral area, jaw, lower extremity, and trunk regions than in those with no formal diagnosis.
Conclusions: Abnormal movements in lips/perioral area, jaw, lower extremities, and trunk were more common in those with formal TD diagnosis.
Short Description: In this real-world study, the proportion of IMPACT-TD Registry participants who experienced abnormal movements (AIMS ≥2) was highest in upper extremities, muscles of facial expression, lips and perioral area, jaw, and tongue, and lowest in lower extremities and trunk regions. Among individuals with no formal TD diagnosis, 67.4% met Schooler-Kane criteria. Abnormal movements in the lips/perioral area, jaw, lower extremities, and trunk were more common in those with formal TD diagnosis versus no diagnosis.
Name of Sponsoring Organization(s): Teva Branded Pharmaceutical Products R&D LLC
