Poster
182
(#182) Bridging the Gap: Psychiatric Disorders in Alzheimer's and Non-Alzheimer's Dementia
Psych Congress 2025
Abstract: Objectives: This study aimed to compare the prevalence of depression, anxiety, and post-traumatic stress disorder (PTSD) in patients with Alzheimer's disease (AD) and non-Alzheimer's mild cognitive impairment (MCI) or mild dementia.
Methods: Participants presented with short-term memory deterioration from February 24th to July 31st, 2025. They were diagnosed with MCI or mild dementia using the Montreal Cognitive Assessment (MoCA) cutoff of less than 26. AD was confirmed using amyloid positron emission tomography (PET) scans. Data collected included age, sex, and psychiatric history (anxiety, depression, PTSD). Group comparisons were made using Fisher's Exact Test and chi-square test. All analyses were conducted using Python (Version 3.9).
Results: 47 patients presented to the neurology clinic for evaluation of mild cognitive impairment. Of these, 31 (66.0%) were AD. The AD group had a mean age of 75.1 years (SD = 7.7), 77.4% female, and a mean MoCA score of 21.2 (SD = 2.6). The non-AD MCI or mild dementia group had a mean age of 74.3 years (SD = 8.2), 37.5% female, and a mean MoCA score of 22.1 (SD = 2.5). Depression prevalence was 41.9% vs. 31.3%, anxiety 22.6% vs. 25.0%, and PTSD 3.2% vs.18.8%, in AD group versus non-AD MCI or mild dementia group.
Conclusion: There were no significant differences in the prevalence of psychiatric comorbidities between AD and non-AD MCI or mild dementia. Given the small sample size, further investigation is needed to better understand the relationship between psychiatric conditions and AD.
Short Description: This study compared the prevalence of depression, anxiety, and PTSD in Alzheimer's disease (AD) versus non-AD mild cognitive impairment or mild dementia. Among 47 patients, 66% had AD. Depression, anxiety, and PTSD prevalence were 41.9%, 22.6%, and 3.2% in AD, versus 31.3%, 25.0%, and 18.8% in non-AD. No significant differences were found, highlighting the need for larger studies to explore psychiatric comorbidities in neurocognitive disorders.
Name of Sponsoring Organization(s): N/A
Methods: Participants presented with short-term memory deterioration from February 24th to July 31st, 2025. They were diagnosed with MCI or mild dementia using the Montreal Cognitive Assessment (MoCA) cutoff of less than 26. AD was confirmed using amyloid positron emission tomography (PET) scans. Data collected included age, sex, and psychiatric history (anxiety, depression, PTSD). Group comparisons were made using Fisher's Exact Test and chi-square test. All analyses were conducted using Python (Version 3.9).
Results: 47 patients presented to the neurology clinic for evaluation of mild cognitive impairment. Of these, 31 (66.0%) were AD. The AD group had a mean age of 75.1 years (SD = 7.7), 77.4% female, and a mean MoCA score of 21.2 (SD = 2.6). The non-AD MCI or mild dementia group had a mean age of 74.3 years (SD = 8.2), 37.5% female, and a mean MoCA score of 22.1 (SD = 2.5). Depression prevalence was 41.9% vs. 31.3%, anxiety 22.6% vs. 25.0%, and PTSD 3.2% vs.18.8%, in AD group versus non-AD MCI or mild dementia group.
Conclusion: There were no significant differences in the prevalence of psychiatric comorbidities between AD and non-AD MCI or mild dementia. Given the small sample size, further investigation is needed to better understand the relationship between psychiatric conditions and AD.
Short Description: This study compared the prevalence of depression, anxiety, and PTSD in Alzheimer's disease (AD) versus non-AD mild cognitive impairment or mild dementia. Among 47 patients, 66% had AD. Depression, anxiety, and PTSD prevalence were 41.9%, 22.6%, and 3.2% in AD, versus 31.3%, 25.0%, and 18.8% in non-AD. No significant differences were found, highlighting the need for larger studies to explore psychiatric comorbidities in neurocognitive disorders.
Name of Sponsoring Organization(s): N/A
