Poster
189
(#189) Real-world Evidence from Facilitated Psilocybin Sessions within Oregon's Legal Framework: Demographics, Engagement, and Motivations.
Psych Congress 2025
Abstract: Psilocybin is increasingly studied for psychiatric conditions, highlighted by recent positive phase 3 results for COMP360, a synthetic psilocybin formulation for treatment-resistant depression. Meanwhile, Oregon's Measure 109 (2020) established the first U.S. legal framework for supervised psilocybin services in licensed settings, which began operating in 2023. Despite this, real-world evidence on individuals accessing these services and their experiences remains limited. This study presents observational data describing the demographics and characteristics of individuals seeking legal facilitated psilocybin sessions.
In this IRB-approved naturalistic study, data were collected between March 2024 and April 2025. Eighty-eight individuals provided survey data. The protocol included eligibility screening, preparation sessions, a single psilocybin session administered at a licensed center, integration sessions, and follow-up surveys at approximately 1 and 30 days after the psilocybin session. Demographics, mental health histories, and open-ended reflections were collected.
Participants ranged from 22 to 79 years old (Mean = 47), with 48% female and 16% military veterans. The sample was predominantly White (95%), with income distribution mirroring national levels (60% earned under $100,000 annually). Residency was split evenly between Oregon locals (49%) and out-of-state visitors (51%). Depression (51%) and anxiety (42%) were the most commonly reported mental health diagnoses, while 36% reported no current psychiatric diagnosis. Nearly half (47%) used psychiatric medications. Adverse effects were minimal, with no serious events and only 3% reporting lingering negative experiences. This study provides valuable early insights into users of legal psilocybin services and their mental health profiles, while highlighting potential access disparities warranting future research.
Short Description: This study characterizes individuals seeking legal facilitated psilocybin sessions in Oregon. Among 88 participants, the majority were White, with balanced representation of local residents and out-of-state visitors. Ages ranged from 22-79 years old, with 48% identifying as female and 16% as military veterans. Common mental health conditions included depression and anxiety, and nearly half used psychiatric medications. These findings offer important insights into the demographic and clinical profile of this emerging treatment population.
Name of Sponsoring Organization(s): Bendable Therapy
Osmind
In this IRB-approved naturalistic study, data were collected between March 2024 and April 2025. Eighty-eight individuals provided survey data. The protocol included eligibility screening, preparation sessions, a single psilocybin session administered at a licensed center, integration sessions, and follow-up surveys at approximately 1 and 30 days after the psilocybin session. Demographics, mental health histories, and open-ended reflections were collected.
Participants ranged from 22 to 79 years old (Mean = 47), with 48% female and 16% military veterans. The sample was predominantly White (95%), with income distribution mirroring national levels (60% earned under $100,000 annually). Residency was split evenly between Oregon locals (49%) and out-of-state visitors (51%). Depression (51%) and anxiety (42%) were the most commonly reported mental health diagnoses, while 36% reported no current psychiatric diagnosis. Nearly half (47%) used psychiatric medications. Adverse effects were minimal, with no serious events and only 3% reporting lingering negative experiences. This study provides valuable early insights into users of legal psilocybin services and their mental health profiles, while highlighting potential access disparities warranting future research.
Short Description: This study characterizes individuals seeking legal facilitated psilocybin sessions in Oregon. Among 88 participants, the majority were White, with balanced representation of local residents and out-of-state visitors. Ages ranged from 22-79 years old, with 48% identifying as female and 16% as military veterans. Common mental health conditions included depression and anxiety, and nearly half used psychiatric medications. These findings offer important insights into the demographic and clinical profile of this emerging treatment population.
Name of Sponsoring Organization(s): Bendable Therapy
Osmind
