Reactions to the International Randomized P4 (Precise Procedural and PCI Plan) Trial
Professors Javier Escaned and Yader Sandoval, interventional cardiologists experienced in CT-guided PCI, share their thoughts on the P4 trial.
Professors Javier Escaned and Yader Sandoval, interventional cardiologists experienced in CT-guided PCI, share their thoughts on the P4 trial.
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The randomized P4 trial, presented by Carlos Collet at TCT 2026, compared coronary CT angiography (CCTA)-guided and intravascular ultrasound (IVUS)-guided PCI strategies in 1,105 patients.
- At 12 months, target vessel failure occurred in 4.1% of the CCTA group and 4.6% of the IVUS group, meeting the trial’s primary endpoint of noninferiority.
- CCTA guidance was also associated with shorter median procedure time (46 vs 63 minutes) and lower median contrast volume during PCI (150 vs 170 mL).
Professors Javier Escaned and Yader Sandoval, interventional cardiologists experienced in CT-guided PCI, share their thoughts on the P4 trial below.
Watch the Video: Yader Sandoval, MD
Prof. Javier Escaned, MD, PhD, Head of the Interventional Cardiology Section at Hospital Clínico San Carlos and Complutense University of Madrid, Spain;
Yader Sandoval, MD, interventional cardiologist at the Minneapolis Heart Institute and Co-Chair of the Center for Coronary Artery Disease at the Minneapolis Heart Institute Foundation. He is also an Adjunct Associate Professor of Medicine at the Mayo Clinic College of Medicine and Science.
