Topera’s Market Leadership in Rotor Mapping Highlighted at Heart Rhythm Society 2014 Scientific Sessions

An Expanding Global User Network Discuss Use of Novel RhythmView™ 3-D Electrophysiologic Mapping System to Identify Sources Sustaining Complex Atrial and Ventricular Arrhythmias Topera, Inc. announced that its FDA-cleared and commercially available 3-D mapping system will be discussed in 14 scientific presentations at the 35th Annual Scientific Sessions of the Heart Rhythm Society (HRS), May 7-10 in San Francisco, CA. Leading physicians from around the world will share new insights about their clinical data and long-term patient outcomes using the Company’s advanced rotor mapping technology. Topera will also showcase the effectiveness and simplicity of the Topera 3-D Mapping System, as well as the company’s latest proprietary feature, the Rotational Activity Profile™ (RAP), in exhibit # 2414. RAP is designed to aid physicians in detecting the specific areas of rotational electrical activity that may sustain complex arrhythmias. “The fact that Topera’s 3-D Mapping System is featured in so many presentations and posters at HRS speaks to the growing adoption of our technology by leading electrophysiologists, both for daily clinical practice and scientific discovery,” said Art Taylor, Topera’s President and Chief Operating Officer. “We are pleased to see Topera recognized as the leader in rotor mapping and that the technology is taking an increasingly prominent role with electrophysiologists who want to better diagnose patients with serious heart rhythm disorders for delivering patient tailored therapies for improved clinical outcomes.” In addition to the main scientific presentations at the Heart Rhythm Society Sessions, there will also be an independent, complimentary CME (continuing medical education) session on Thursday, May 8 at 6:30 p.m. PDT, titled “3-D Mapping & Ablation of AF Rotors: A Paradigm Shift in Standard of Care to Improve Long-term Outcomes in AF Ablation.” This educational session will be chaired by Dr. Vivek Reddy (Mt Sinai, New York City, NY) and will include scientific presentations by Drs. Gerhard Hindricks (German Heart Center, Leipzig, Germany), John Miller (Indiana University Health, Indianapolis, Indiana), and Gery Tomassoni (Central Baptist Hospital, Lexington, Kentucky). For more information regarding this session and to register, go to www.InnovationsInCRM.com/afrotors. Schedule of scientific presentations (All times are Pacific time, with events to be held at the Moscone Center): Wednesday, May 7th 1:00 pm, Room 3001, Moscone West Sanjiv Narayan, MD, PhD, FHRS – University of California and San Diego VA Medical Center AF Summit: Focal Source & Rotor Identification in Patients What it Teaches Us About Mechanisms of Persistent AF 6:00 pm, Poster Town Stephanie Yoakum, NP –San Diego VA Medical Center Poster Session I: PO01-525 Patient-Tailored Rotor Ablation for Persistent Atrial Fibrillation Reduces Recurrence in the Blanking Period Compared To Trigger-Based Ablation Alone 6:00 pm, Poster Town Sanjiv Narayan, MD, PhD, FHRS – University of California and San Diego VA Medical Center Poster Session I: PO01-57 Prevention of Late (3 Year) Recurrence of Atrial Arrhythmias by Ablation of Rotor and Focal Sources (FIRM) Compared to Trigger Ablation Alone: Late Follow up of the CONFIRM Trial 6:00 pm, Poster Town John Miller, MD, FHRS – Indiana University School of Medicine Poster Session I: PO01-127 Similar Long Term Freedom From Persistent or Paroxysmal Atrial Fibrillation After Ablation of Patient-Specific Rotors and Focal Sources: Multicenter FIRM Study 6:00 pm, Poster Town Tina Baykaner, MD – University of California, San Diego Poster Session I: PO01-129 Diverse Locations of Bi-atrial Rotors and Focal Sources in Atrial Fibrillation: Similarity Between Extended Series and the original CONFIRM Trial 6:00 pm, Poster Town Vijay Swarup, MD, FHRS – Arizona Heart Rhythm Center, Phoenix, AZ Poster Session I: PO01-152 Acute Termination of Atrial Fibrillation Does Not Predict Long-Term Outcome After Rotor Elimination by Focal Impulse and Rotor Modulation (FIRM): Multicenter FIRM-AF Registry Thursday, May 8th 9:30 am, Poster Town Gautam Lalani, MD – University of California, San Diego Poster Session II: PO02-104 Very Long Term Success of Rotor Ablation and Mechanism of Recurrent Atrial Fibrillation are Independent of Use of Irrigated vs. Non-irrigated Ablation Catheters 12:55 pm, Room 2002, Moscone West Sanjiv Narayan, MD, PhD, FHRS – University of California and San Diego VA Medical Center Meet the Experts: Drivers & Substrate of AF: Can We Ablate a Rotor? 4:55 pm, Room 2002, Moscone West, John Miller, MD, FHRS – Indiana University School of Medicine Clinical Electrophysiology Core Curricula: Rotor Mapping of Complex Arrhythmias Friday, May 9th 9:30 am, Poster Town Christine Lemers, MD, AK St Georg, Hamburg, Germany Poster Session IV: PO04-85 Comparison of Atrial Fibrillation Rotors Identified by Endocardial Versus Epicardial Rotor Mapping 10:30 am, Room 104, Moscone South Sanjiv Narayan, MD, PhD, FHRS – University of California and San Diego VA Medical Center Debate: Persistent AF is Due to Rotors 1:45 pm, Room 132, Moscone North Amir Schricker, MD – University of California, San Diego Oral Abstract Session: Persistent Atrial Fibrillation Rotors May Explain Post-Ablation Recurrence 2:00 pm, Poster Town Roland Tilz, MD – AK St Georg, Hamburg, Germany Poster Session V: PO05-75 Locations of Human Atrial Fibrillation Rotors: Rotors Identified Frequently in the Pulmonary Veins Saturday, May 10th 9:30 am, Poster Town Dan Muscat, MD – Valley Health System, Ridgewood, NJ Poster Session VI: PO06-48 Atrial Fibrillation Source Location Identification by Focal Impulse and Rotor Modulation Technique During Ablation About Topera Topera (Topera, Inc.), a venture backed medical device company, has developed a novel 3-D analysis and mapping system to assist electrophysiologists in the identification of the electrical source of complex cardiac arrhythmias. The Topera 3-D Mapping System is designed to improve patient outcomes by enabling electrophysiologists to view a dynamic representation of the electrical activity of the heart, supporting the diagnosis of and treatment planning for a variety of arrhythmias including atrial fibrillation, atrial flutter, atrial tachycardia, and ventricular tachycardia. For additional information, visit www.toperamedical.com.