PsA Associated With Risk of Vertebral Fracture
Researchers conducted a systematic review and meta-analysis of cohort studies including patients with and without psoriatic arthritis (PsA) who were followed for incident vertebral fractures and found that patients with PsA showed increased risk of such fractures.
Three investigators conducted 2 rounds of independent review of 26,090 articles that met initial criteria. Five cohort studies met the eligibility criteria for the meta-analysis.
“Studies were also required to report standardized incidence ration, hazard risk ratio or relative risk with related 95% confidence intervals (CI) comparing the incidence of vertebral fracture between the two cohorts,” the authors stated. “The retrieved point estimates with standard errors from each study were pooled into the final result by the random-effect model and generic inverse variance method.”
The final analysis revealed that PsA is significantly associated with vertebral fracture, the researchers concluded, “with a pooled odds ratio of 2.09 (95% CI, 1.11 - 3.96; I2 70%). The funnel plot was fairly asymmetric, thus the publication bias in favor of studies may present.”
—Rebecca Mashaw
Reference:
Charoenngam N, Ponvilawan B, Thongpiya J, Yingchoncharoen P, Ungprasert P. Psoriatic arthritis and risk of vertebral fracture: A systematic review and meta-analysis. Curr Rheumatol Rev. 2022;18(1):64-71. DOI: 10.2174/1573397117666210908094349
