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Primary Humoral Immunodeficiency Topic Center

Exclusives

News
Pregnancy Requires Care Adjustment for Primary Immunodeficiency Disease
06/22/2023
Jolynn Tumolo
Multidisciplinary management, including prophylaxis against infection, helps increase the potential for a healthy pregnancy among patients with primary immune deficiencies, researchers say.
Multidisciplinary management, including prophylaxis against infection, helps increase the potential for a healthy pregnancy among patients with primary immune deficiencies, researchers say.
Multidisciplinary management,...
06/22/2023
Rheumatology & Arthritis
laptop with stethoscope
News
Model Signals Primary Immunodeficiency Disease Based on History of Symptomatic Care
06/08/2023
Jolynn Tumolo
Combining electronic health record data such as laboratory tests, radiological orders, and medications provides improved detection of primary immunodeficiency disease, research shows.
Combining electronic health record data such as laboratory tests, radiological orders, and medications provides improved detection of primary immunodeficiency disease, research shows.
Combining electronic health...
06/08/2023
Rheumatology & Arthritis
gastrointestinal
News
Patients With Common Variable Immune Deficiency Often Present GI Complications
05/31/2023
Jolynn Tumolo
Multidisciplinary care of patients with common variable immune deficiency is important in addressing frequent noninfectious gastrointestinal manifestations, researchers say.
Multidisciplinary care of patients with common variable immune deficiency is important in addressing frequent noninfectious gastrointestinal manifestations, researchers say.
Multidisciplinary care of...
05/31/2023
Rheumatology & Arthritis
infection + immunology
News
Patients With PI Often Present With Noninfectious Manifestations
05/24/2023
Malignancies, allergic reactions, and autoimmune-inflammatory manifestations occur with some frequency among patients with primary immunodeficiency diseases.
Malignancies, allergic reactions, and autoimmune-inflammatory manifestations occur with some frequency among patients with primary immunodeficiency diseases.
Malignancies, allergic...
05/24/2023
Rheumatology & Arthritis
News
Persistent Viral Infections May Signal Primary Immunodeficiency Disease
03/16/2023
Jolynn Tumolo
Viral infections can be the most significant morbidity in some patients with primary immunodeficiency disease, researchers say.
Viral infections can be the most significant morbidity in some patients with primary immunodeficiency disease, researchers say.
Viral infections can be the most...
03/16/2023
Rheumatology & Arthritis
News
Understanding Skin Conditions Among Patients with Primary Immunodeficiencies
12/11/2022
Better understanding of common cutaneous manifestations among patients with primary immunodeficiencies can enhance timely diagnosis and treatment plans.
Better understanding of common cutaneous manifestations among patients with primary immunodeficiencies can enhance timely diagnosis and treatment plans.
Better understanding of common...
12/11/2022
Rheumatology & Arthritis
News
Manifestations of Primary Immunodeficiencies Beyond Infections
11/29/2022
Better knowledge of the initial presenting manifestations of primary immunodeficiencies (or inborn errors of immunity) may improve awareness and avoid diagnostic delay.
Better knowledge of the initial presenting manifestations of primary immunodeficiencies (or inborn errors of immunity) may improve awareness and avoid diagnostic delay.
Better knowledge of the initial...
11/29/2022
Rheumatology & Arthritis
News
Using Nordic Score With Pediatric ITP
11/03/2022
Researchers examined whether Nordic score is useful for predicting clinical response among pediatric patients with immune thrombocytopenia.
Researchers examined whether Nordic score is useful for predicting clinical response among pediatric patients with immune thrombocytopenia.
Researchers examined whether...
11/03/2022
Rheumatology & Arthritis
News
Primary Immunodeficiency and Fatigue
10/27/2022
Experts studied the prevalence of fatigue among patients with primary immunodeficiency and investigated the associated factors.
Experts studied the prevalence of fatigue among patients with primary immunodeficiency and investigated the associated factors.
Experts studied the prevalence...
10/27/2022
Rheumatology & Arthritis
News
Update: COVID and Influenza Vaccination for Patients With Primary Immunodeficiency
10/27/2022
Patients who are moderately or severely immunocompromised are encouraged to stay up to date with their COVID-19 and influenza vaccination schedules in order to stay healthy this flu season.
Patients who are moderately or severely immunocompromised are encouraged to stay up to date with their COVID-19 and influenza vaccination schedules in order to stay healthy this flu season.
Patients who are moderately or...
10/27/2022
Rheumatology & Arthritis
News
ITP Associated With Thyroid Disease
10/26/2022
Patients diagnosed with immune thrombocytopenia were often found to have comorbid thyroid disease.
Patients diagnosed with immune thrombocytopenia were often found to have comorbid thyroid disease.
Patients diagnosed with immune...
10/26/2022
Rheumatology & Arthritis

News

Interactive Features

Quiz
Progression from PsO to PsA
04/28/2026
Rebecca Mashaw
Do you know which patients with psoriasis are most at risk of progression to psoriatic arthritis? Take our quick quiz to find out!
Do you know which patients with psoriasis are most at risk of progression to psoriatic arthritis? Take our quick quiz to find out!
Do you know which patients with...
04/28/2026
Rheumatology & Arthritis
Quiz
Treat-to-Target vs Symptom-Based Gout Care: What’s the Difference?
04/01/2026
Riya Gandhi, MA
Test your understanding of gout management strategies by comparing serum urate treat-to-target approaches with symptom-guided care. This quiz highlights key clinical principles shaping modern gout treatment and long-term disease control.
Test your understanding of gout management strategies by comparing serum urate treat-to-target approaches with symptom-guided care. This quiz highlights key clinical principles shaping modern gout treatment and long-term disease control.
Test your understanding of gout...
04/01/2026
Rheumatology & Arthritis
Quiz
Why Flare Frequency Matters in Clinical Trials
04/01/2026
Riya Gandhi, MA
Explore why gout flare frequency remains a key primary outcome in clinical trials despite the disease’s chronic and erosive nature. This quiz reinforces outcome selection and trial design principles in gout research.
Explore why gout flare frequency remains a key primary outcome in clinical trials despite the disease’s chronic and erosive nature. This quiz reinforces outcome selection and trial design principles in gout research.
Explore why gout flare frequency...
04/01/2026
Rheumatology & Arthritis
Quiz
Hyperuricemia vs Gout: Understanding the Clinical Relationship
04/01/2026
Riya Gandhi, MA
Test your knowledge of the relationship between hyperuricemia and clinical gout. This quiz clarifies key distinctions that impact diagnosis, risk assessment, and treatment decisions in rheumatology practice.
Test your knowledge of the relationship between hyperuricemia and clinical gout. This quiz clarifies key distinctions that impact diagnosis, risk assessment, and treatment decisions in rheumatology practice.
Test your knowledge of the...
04/01/2026
Rheumatology & Arthritis
Quiz
Pegloticase + Methotrexate: What Rising Uric Acid Means
04/01/2026
Riya Gandhi, MA
Assess your understanding of pegloticase therapy by interpreting rising serum urate levels in combination treatment protocols. This quiz highlights key monitoring principles and response criteria from the AGILE trial.
Assess your understanding of pegloticase therapy by interpreting rising serum urate levels in combination treatment protocols. This quiz highlights key monitoring principles and response criteria from the AGILE trial.
Assess your understanding of...
04/01/2026
Rheumatology & Arthritis
Quiz
Sex-Based Differences in Response to Advanced Therapies in Axial Spondyloarthritis
08/07/2025
Rebecca Mashaw
Do men or women achieve better outcomes with advanced therapies for axial spondyloarthritis? Find out by taking our quick quiz.
Do men or women achieve better outcomes with advanced therapies for axial spondyloarthritis? Find out by taking our quick quiz.
Do men or women achieve better...
08/07/2025
Rheumatology & Arthritis
Quiz
What Factor Increases Mortality in Rheumatoid Arthritis?
08/07/2025
Rebecca Mashaw
One factor showed a substantial association with mortality among patients with rheumatoid arthritis. Find out what it is with our quiz!
One factor showed a substantial association with mortality among patients with rheumatoid arthritis. Find out what it is with our quiz!
One factor showed a substantial...
08/07/2025
Rheumatology & Arthritis
Quiz
How to Assess Frailty in SLE
07/21/2025
Rebecca Mashaw
07/21/2025
Rheumatology & Arthritis
Quiz
Continuation of Therapy With bDMARDs vs JAKs in RA
07/21/2025
Rebecca Mashaw
07/21/2025
Rheumatology & Arthritis
Quiz
NSAIDs and axSpA
08/30/2024
Riya Gandhi, MA
Is there any association between nonsteroidal anti-inflammatory drugs (NSAIDs), axial spondyloarthritis (axSpA), and risk of cardiovascular disease (CVD)?a) No, there is no evidence that NSAID use increases the risk of CVD on patients with...
Is there any association between nonsteroidal anti-inflammatory drugs (NSAIDs), axial spondyloarthritis (axSpA), and risk of cardiovascular disease (CVD)?a) No, there is no evidence that NSAID use increases the risk of CVD on patients with...
Is there any association between...
08/30/2024
Rheumatology & Arthritis

Podcasts

Philip Mease
Expert Insights
Philip Mease, MD, on the POETYK Trials of Deucravacitinib in PsA
05/11/2026
Philip Mease, MD
In part 1 of a two-part podcast, Dr Mease reviews the findings of two clinical trials of the TYK 2 inhibitor deucravacitinib: POETYK 1 of patients without previous biologic treatment, POETYK 2, which included some patients with exposure to...
In part 1 of a two-part podcast, Dr Mease reviews the findings of two clinical trials of the TYK 2 inhibitor deucravacitinib: POETYK 1 of patients without previous biologic treatment, POETYK 2, which included some patients with exposure to...
In part 1 of a two-part podcast,...
05/11/2026
Rheumatology & Arthritis
Shikha Singla
Expert Insights
Shikha Singla, MD, on Comparative Analysis of Guidelines for PsA
05/11/2026
Shikha Singla, MD
Dr Singla reviews the comparative analysis she and colleagues conducted of guidelines for the diagnosis and treatment of psoriatic arthritis and how they differ between the professional societies.
Dr Singla reviews the comparative analysis she and colleagues conducted of guidelines for the diagnosis and treatment of psoriatic arthritis and how they differ between the professional societies.
Dr Singla reviews the...
05/11/2026
Rheumatology & Arthritis
Shikha Singla
Expert Insights
Shikha Singla, MD, on Comparative Analysis of Guidelines for PsA
05/10/2026
Shikha Singla, MD
Dr Singla reviews the comparative analysis she and colleagues conducted of guidelines for the diagnosis and treatment of psoriatic arthritis and how they differ between the professional societies.
Dr Singla reviews the comparative analysis she and colleagues conducted of guidelines for the diagnosis and treatment of psoriatic arthritis and how they differ between the professional societies.
Dr Singla reviews the...
05/10/2026
Rheumatology & Arthritis
Philip Mease
Expert Insights
Philip Mease, MD, on the POETYK Trials of Deucravacitinib in PsA: Part 2
04/30/2026
Philip Mease, MD
Dr Mease continues his review of the findings of the POETYK clinical trials of the TYK 2 inhibitor deucravacitinib, including patient-reported outcomes among patients treated with the therapy.
Dr Mease continues his review of the findings of the POETYK clinical trials of the TYK 2 inhibitor deucravacitinib, including patient-reported outcomes among patients treated with the therapy.
Dr Mease continues his review of...
04/30/2026
Rheumatology & Arthritis
Philip Mease
Expert Insights
Philip Mease, MD, on the POETYK Trials of Deucravacitinib in PsA
04/23/2026
Philip Mease, MD
In part 1 of a two-part podcast, Dr Mease reviews the findings of two clinical trials of the TYK 2 inhibitor deucravacitinib: POETYK 1 of patients without previous biologic treatment, POETYK 2, which included some patients with exposure to...
In part 1 of a two-part podcast, Dr Mease reviews the findings of two clinical trials of the TYK 2 inhibitor deucravacitinib: POETYK 1 of patients without previous biologic treatment, POETYK 2, which included some patients with exposure to...
In part 1 of a two-part podcast,...
04/23/2026
Rheumatology & Arthritis
Expert Insights
Daniel Solomon, MD, on Treat to Target vs Symptoms in Gout
02/04/2026
Daniel Hal Solomon, MD
In this podcast, Dr Solomon reviews the design of, recruitment for, and established outcomes of the TRUST trial, a randomized controlled active comparator strategy for gout to compare a treat to target serum urate strategy versus an approach...
In this podcast, Dr Solomon reviews the design of, recruitment for, and established outcomes of the TRUST trial, a randomized controlled active comparator strategy for gout to compare a treat to target serum urate strategy versus an approach...
In this podcast, Dr Solomon...
02/04/2026
Rheumatology & Arthritis
Dacre Knight
Podcast
Dacre Knight, MD, on Hypermobility
04/30/2025
Dacre Knight, MD
Dacre Knight, MD, from Mayo Clinic-Florida, provides insights into hypermobility disorders, including Ehlers-Danlos Syndrome, and why they are difficult to diagnose and challenging to treat.
Dacre Knight, MD, from Mayo Clinic-Florida, provides insights into hypermobility disorders, including Ehlers-Danlos Syndrome, and why they are difficult to diagnose and challenging to treat.
Dacre Knight, MD, from Mayo...
04/30/2025
Rheumatology & Arthritis
Len Calabrese
Podcast
Leonard Calabrese, DO, on Long COVID Similarities to Fibromyalgia, ME/CFS
01/02/2025
Leonard Calabrese, DO
Dr Calabrese discusses the similarities between long COVID, fibromyalgia, and in its most severe form, myalgic encephalomyelitis/chronic fatigue syndrome, and the importance of reassuring patients that their symptoms and conditions are real.
Dr Calabrese discusses the similarities between long COVID, fibromyalgia, and in its most severe form, myalgic encephalomyelitis/chronic fatigue syndrome, and the importance of reassuring patients that their symptoms and conditions are real.
Dr Calabrese discusses the...
01/02/2025
Rheumatology & Arthritis
Misti Paudel
Podcast
Misti Paudel, PhD, on Difficult-to-Treat Rheumatoid Arthritis
08/12/2024
Dr Paudel reviews research she and colleagues conducted to validate the EULAR definition of difficult-to-treat rheumatoid arthritis, and differences among patients with difficult-to-treat RA versus those with controlled disease.
Dr Paudel reviews research she and colleagues conducted to validate the EULAR definition of difficult-to-treat rheumatoid arthritis, and differences among patients with difficult-to-treat RA versus those with controlled disease.
Dr Paudel reviews research she...
08/12/2024
Rheumatology & Arthritis
Vikas Majithia
Podcast
Vikas Majithia, MD, and Ronald Butendieck, MD, on the Continuing Challenges of Gout
06/20/2024
Drs Majithia and Butendieck provide some perspective on the continuing issues surrounding the diagnosis and effective treatment of gout, the most common inflammatory arthritis in the US.
Drs Majithia and Butendieck provide some perspective on the continuing issues surrounding the diagnosis and effective treatment of gout, the most common inflammatory arthritis in the US.
Drs Majithia and Butendieck...
06/20/2024
Rheumatology & Arthritis

Popular Articles

News
MRI Classification Aids Interpretation of Images for axSpA
09/13/2024
Jessica Garlewicz
A novel magnetic resonance imaging categorization system improved interpretation consistency between clinicians and radiologists, possibly enhancing the accuracy of clinical decision-making.
A novel magnetic resonance imaging categorization system improved interpretation consistency between clinicians and radiologists, possibly enhancing the accuracy of clinical decision-making.
A novel magnetic resonance...
09/13/2024
Rheumatology & Arthritis
Vikas Majithia
Podcast
Vikas Majithia, MD, and Ronald Butendieck, MD, on the Continuing Challenges of Gout
06/20/2024
Drs Majithia and Butendieck provide some perspective on the continuing issues surrounding the diagnosis and effective treatment of gout, the most common inflammatory arthritis in the US.
Drs Majithia and Butendieck provide some perspective on the continuing issues surrounding the diagnosis and effective treatment of gout, the most common inflammatory arthritis in the US.
Drs Majithia and Butendieck...
06/20/2024
Rheumatology & Arthritis
News
MRI Can Reveal Unexpected Issues Among Middle-Aged Adults With Knee Pain
10/18/2024
Jessica Garlewicz
Clinicians should be mindful of potential surprise findings on imaging that may necessitate changes in treatment.
Clinicians should be mindful of potential surprise findings on imaging that may necessitate changes in treatment.
Clinicians should be mindful of...
10/18/2024
Rheumatology & Arthritis
Poll
Assessing Bone Loss in Patients With axSpA
12/05/2024
Rebecca Mashaw
Bone loss has been found to play a significant role in axial spondyloarthritis (axSpA) and regular assessments are recommended. How do you assess bone loss in your patients with axSpA?DXA scanTrabecular bone score Quantitative computed...
Bone loss has been found to play a significant role in axial spondyloarthritis (axSpA) and regular assessments are recommended. How do you assess bone loss in your patients with axSpA?DXA scanTrabecular bone score Quantitative computed...
Bone loss has been found to play...
12/05/2024
Rheumatology & Arthritis
News
Meta-Analysis Finds Robust Evidence Supporting Upadacitinib for axSpA
09/18/2024
Jolynn Tumolo
Upadacitinib was associated with significant improvements in several key outcomes, including low disease activity.
Upadacitinib was associated with significant improvements in several key outcomes, including low disease activity.
Upadacitinib was associated with...
09/18/2024
Rheumatology & Arthritis

Partner Spotlight

Axial Involvement in SpA: A Patient-Centered Exploration, Chapter 1
SPONSORED
Axial Involvement in SpA, Chapter 1
04/26/2022
Ethan Craig, MD, MPH, discusses 3 of his patient cases to identify and differentiate axial involvement within the spectrum of SpA.
Ethan Craig, MD, MPH, discusses 3 of his patient cases to identify and differentiate axial involvement within the spectrum of SpA.
Ethan Craig, MD, MPH, discusses...
04/26/2022
Rheumatology & Arthritis

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