Tanaz Kermani, MD, on ANCA-Associated Vasculitis Treatment Strategies
In this podcast, Tanaz Kermani, MD, MS, provides an in-depth look at antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Listen as she discusses treatment strategies, duration of therapy, and the timing of renal transplantation for patients with microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), or eosinophilic granulomatosis with polyangiitis (EGPA).
Tanaz Kermani, MD, MS, is an associate clinical professor in the Division of Rheumatology at the University of California, Los Angeles, where she is also director of the multidisciplinary Vasculitis Program.
Additional Resources:
Lyons PA, Rayner TF, Trivedi S, et al. Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med 2012;367:214-223. doi:10.1056/NEJMoa1108735
Damoiseaux J, Csernok E, Rasmussen N, et al. Detection of antineutrophil cytoplasmic antibodies (ANCAs): a multicentre European Vasculitis Study Group (EUVAS) evaluation of the value of indirect immunofluorescence (IIF) versus antigen-specific immunoassays. Ann Rheum Dis 2017;76(4):647-653. doi:10.1136/annrheumdis-2016-209507
Stone JH, Merkel PA, Spiera R, et al; RAVE−ITN research group. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med. 2010;363:221-232. doi:10.1056/NEJMoa0909905
Jones RB, Tervaert JWC, Hauser T, et al; European Vasculitis Study Group. Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis. N Engl J Med. 2010;363:211-220. doi:10.1056/NEJMoa0909169
Walsh M, Merkel PA, Peh CA, et al; PEXIVAS investigators. Plasma exchange and glucocorticoids in severe ANCA-associated vasculitis. N Engl J Med. 2020;382(7):622-631. doi:10.1056/NEJMoa1803537
Wechsler ME, Akuthota P, Jayne D, et al; EGPA mepolizumab study team. Mepolizumab or placebo for eosinophilic granulomatosis with polyangiitis. N Engl J Med. 2017;376(20):1921-1932. doi:10.1056/NEJMoa1702079
Mohammad AJ, Hot A, Arndt F, et al. Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Ann Rheum Dis 2016;75(2):396-401. doi:10.1136/annrheumdis-2014-206095
Puéchal X, Iudici M, Calich AL, et al. Rituximab for induction and maintenance therapy of granulomatosis with polyangiitis: a single-centre cohort study on 114 patients. Rheumatology (Oxford). 2019;58(3):401-409. doi:10.1093/rheumatology/key117
Guillevin L, Pagnoux C, Karras A et al. Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis. N Engl J Med 2014;371(19):1771-1780. doi:10.1056/NEJMoa1404231
Gopaluni S, Smith RM, Lewin M, et al; RITAZAREM investigators. Rituximab versus azathioprine as therapy for maintenance of remission for anti-neutrophil cytoplasm antibody-associated vasculitis (RITAZAREM): study protocol for a randomized controlled trial. Trials. 2017;18(1):112. doi:10.1186/s13063-017-1857-z
Yates M, Watts RA, Bajema IM, et al. EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis. Ann Rheum Dis. 2016;75(9):1583-1594. doi:10.1136/annrheumdis-2016-209133
Jayne DRW, Bruchfeld AN, Harper L, et al; CLEAR study group. Randomized trial of C5a receptor inhibitor avacopan in ANCA-associated vasculitis. J Am Soc Nephrol. 2017;28(9):2756-2767. doi:10.1681/ASN.2016111179
Merkel PA, Jayne DR, Wang C, et al. Evaluation of the safety and efficacy of avacopan, a C5a receptor inhibitor, in patients with antineutrophil cytoplasmic antibody-associated vasculitis treated concomitantly with rituximab or cyclophosphamide/azathioprine: protocol for a randomized, double-blind, active-controlled, phase 3 trial. JMIR Res Protoc. 2020;9:e1666. doi:10.2196/16664
Langford CA, Monach PA, Specks U, et al. An open-label trial of abatacept (CTLA4-IG) in non-severe relapsing granulomatosis with polyangiitis (Wegener's). Ann Rheum Dis. 2014;73:1376-1379. doi:10.1136/annrheumdis-2013-204164
