Type 2 Inflammation as an Underlying Disease Driver
Dr Raj Chovatiya moderates an expert roundtable with Drs. Tina Bhutani, Daniel Butler, and Jason Hawkes, exploring how type 2 inflammation drives chronic inflammatory skin diseases, including atopic dermatitis, prurigo nodularis, and chronic spontaneous urticaria. The discussion examines the roles of IL-4, IL-13, and IL-31 in immune dysregulation, skin barrier dysfunction, neuroimmune signaling, and chronic itch. The panel highlights how overlapping inflammatory pathways and variable responses to biologics and JAK inhibitors can inform treatment selection and reveal underlying disease mechanisms.
Dermatologists will gain clinically relevant insights into recognizing inflammatory phenotypes, evaluating inadequate treatment responses, identifying potential disease overlap or phenotype switching, and refining therapeutic strategies when targeted treatments fail to achieve adequate disease control.
