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The Cost-Effectiveness of the JAKPOT Prediction Rule for Erythrocytosis
09/11/2026
Rebecca Amrick
Researchers found upfront JAK2 testing to be more cost-effective in US settings than the JAKPOT predication rule when identifying JAK2 mutations among patients with erythrocytosis.
Researchers found upfront JAK2 testing to be more cost-effective in US settings than the JAKPOT predication rule when identifying JAK2 mutations among patients with erythrocytosis.
Researchers found upfront JAK2...
09/11/2026
First Report Managed Care
News
Considering Time Burden Across Bispecific Antibody Treatment Approaches in Non-Hodgkin Lymphoma
09/10/2026
Rebecca Amrick
A survey of patients with relapsed or refractory follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) found lower time burden with fixed-duration bispecific antibody regimens, highlighting patient convenience as a crucial factor...
A survey of patients with relapsed or refractory follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) found lower time burden with fixed-duration bispecific antibody regimens, highlighting patient convenience as a crucial factor...
A survey of patients with...
09/10/2026
First Report Managed Care
News
Extended-Release Buprenorphine Adherence Linked to Lower Health Care Utilization in OUD
09/10/2026
Rebecca Amrick
Researchers found that adherence to extended-release buprenorphine was associated with reduced acute care utilization and lower care costs among patients with opioid use disorder (OUD).
Researchers found that adherence to extended-release buprenorphine was associated with reduced acute care utilization and lower care costs among patients with opioid use disorder (OUD).
Researchers found that adherence...
09/10/2026
First Report Managed Care
News
Next-Generation TKIs Show Similar Real-World Outcomes and Costs in ALK-Positive mNSCLC
09/09/2026
Rebecca Amrick
A real-world comparison of alectinib, brigatinib, and lorlatinib found no significant differences in clinical or economic outcomes among patients with anaplastic lymphoma kinase (ALK)-positive metastatic non–small cell lung cancer (mNSCLC).
A real-world comparison of alectinib, brigatinib, and lorlatinib found no significant differences in clinical or economic outcomes among patients with anaplastic lymphoma kinase (ALK)-positive metastatic non–small cell lung cancer (mNSCLC).
A real-world comparison of...
09/09/2026
First Report Managed Care
News
Real-World Abrocitinib Use Shows Stable Dosing in US Patients With Atopic Dermatitis
09/08/2026
Grace Taylor, MS, MA
A US real-world study found that most patients with atopic dermatitis initiated abrocitinib at 100 mg and maintained their starting dose for up to 12 months.
A US real-world study found that most patients with atopic dermatitis initiated abrocitinib at 100 mg and maintained their starting dose for up to 12 months.
A US real-world study found that...
09/08/2026
First Report Managed Care
News
Significant Care Costs for Obesity Medications Associated With High Rates of Treatment Discontinuation
09/08/2026
Rebecca Amrick
Researchers found that newer obesity medications were associated with higher drug and total care costs as well as nonsignificant changes in health care utilization compared to phentermine, raising concerns about access for patients with...
Researchers found that newer obesity medications were associated with higher drug and total care costs as well as nonsignificant changes in health care utilization compared to phentermine, raising concerns about access for patients with...
Researchers found that newer...
09/08/2026
First Report Managed Care
Behind the Bill
Trump Administration Expands Most-Favored-Nation Drug Pricing Agreements
09/03/2026
Grace Taylor, MS, MA
The Trump Administration’s agreements with 9 additional drugmakers expand most-favored-nation pricing commitments, potentially lowering prescription drug costs for state Medicaid programs.
The Trump Administration’s agreements with 9 additional drugmakers expand most-favored-nation pricing commitments, potentially lowering prescription drug costs for state Medicaid programs.
The Trump Administration’s...
09/03/2026
First Report Managed Care
News
The Impact of Asciminib on Patients With Pretreated CML-CP
09/03/2026
Rebecca Amrick
The ASC4OPT study found that asciminib demonstrated comparable efficacy across dosing regimens in patients with pretreated chronic myeloid leukemia in chronic phase (CML-CP), supporting its potential role as a treatment option for patients...
The ASC4OPT study found that asciminib demonstrated comparable efficacy across dosing regimens in patients with pretreated chronic myeloid leukemia in chronic phase (CML-CP), supporting its potential role as a treatment option for patients...
The ASC4OPT study found that...
09/03/2026
First Report Managed Care
News
Medical Claim Denial Disparities Across Payers and Safety-Net Providers
09/02/2026
Rebecca Amrick
A study found that safety-net providers were more likely to receive medical claim denials than non–safety-net providers, highlighting gaps in coverage that should be addressed in future policy reforms.
A study found that safety-net providers were more likely to receive medical claim denials than non–safety-net providers, highlighting gaps in coverage that should be addressed in future policy reforms.
A study found that safety-net...
09/02/2026
First Report Managed Care
Behind the Bill
Rural Health Transformation Program Funding Rolls Out Across States
08/28/2026
Grace Taylor, MS, MA
The Centers for Medicare & Medicaid Services (CMS) is rolling out Rural Health Transformation Program funding across states, supporting projects aimed at expanding access, modernizing infrastructure, and strengthening rural health care...
The Centers for Medicare & Medicaid Services (CMS) is rolling out Rural Health Transformation Program funding across states, supporting projects aimed at expanding access, modernizing infrastructure, and strengthening rural health care...
The Centers for Medicare &...
08/28/2026
First Report Managed Care

Pipeline Projections

PIPELINE PROJECTIONS
The Evolving Alzheimer Disease Treatment Landscape: Anti-Amyloid Therapies and Beyond
07/21/2026
Roy Moore
Roy Moore explores the evolving Alzheimer's disease pipeline, highlighting the promise of anti-amyloid therapies, emerging competitors, and the challenges ahead.
Roy Moore explores the evolving Alzheimer's disease pipeline, highlighting the promise of anti-amyloid therapies, emerging competitors, and the challenges ahead.
Roy Moore explores the evolving...
07/21/2026
First Report Managed Care
PIPELINE PROJECTIONS
Emerging Therapies Reshaping Atopic Dermatitis Care
03/26/2026
Roy Moore
Roy Moore outlines how a rapidly expanding atopic dermatitis pipeline is intensifying competition, reshaping payer strategies, and raising the bar for new therapies.
Roy Moore outlines how a rapidly expanding atopic dermatitis pipeline is intensifying competition, reshaping payer strategies, and raising the bar for new therapies.
Roy Moore outlines how a rapidly...
03/26/2026
First Report Managed Care
Pipe
Pipeline Projections
Emerging Migraine Treatments Challenge a Mature Market
11/20/2025
Roy Moore
Roy Moore of Clarivate’s market access team discussed the evolving migraine treatment landscape, highlighting the maturation of the acute and prophylactic markets, the emergence of new therapies such as triptan-COX-2 combinations, gepants,...
Roy Moore of Clarivate’s market access team discussed the evolving migraine treatment landscape, highlighting the maturation of the acute and prophylactic markets, the emergence of new therapies such as triptan-COX-2 combinations, gepants,...
Roy Moore of Clarivate’s market...
11/20/2025
First Report Managed Care
Pipeline Projections
Pipeline Projections
Redefining Asthma Management With Emerging Anti-Inflammatories
10/01/2025
Roy Moore
Roy Moore, a market access expert, discusses the evolving asthma drug pipeline, highlighting upcoming therapies—including Breztri, depemokimab, and masitinib—their potential to improve adherence and outcomes, payer considerations around cost...
Roy Moore, a market access expert, discusses the evolving asthma drug pipeline, highlighting upcoming therapies—including Breztri, depemokimab, and masitinib—their potential to improve adherence and outcomes, payer considerations around cost...
Roy Moore, a market access...
10/01/2025
First Report Managed Care
Pipeline Projections
The Shift in MS Care as Biologics and BTK Inhibitors Advance
07/25/2025
Roy Moore
In this edition of Pipeline Projections, Roy Moore breaks down the rapidly evolving landscape of multiple sclerosis treatments—highlighting the shift from injectables to orals, the rise of monoclonal antibodies, and the promise of innovative...
In this edition of Pipeline Projections, Roy Moore breaks down the rapidly evolving landscape of multiple sclerosis treatments—highlighting the shift from injectables to orals, the rise of monoclonal antibodies, and the promise of innovative...
In this edition of Pipeline...
07/25/2025
First Report Managed Care

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Behind the Bill

Behind the Bill
HHS Hits Reset on 340B Rebate Model After Court Setbacks
02/11/2026
Juliet Gallagher
The US Department of Health and Human Services (HHS) has formally scrapped its 340B Rebate Model Pilot Program following a series of court rulings that blocked its implementation—signaling a significant pause in one of the most closely...
The US Department of Health and Human Services (HHS) has formally scrapped its 340B Rebate Model Pilot Program following a series of court rulings that blocked its implementation—signaling a significant pause in one of the most closely...
The US Department of Health and...
02/11/2026
First Report Managed Care
Behind the Bill
Funding Package Extends Medicare Telehealth, Enacts PBM Reforms, and Updates Hospital Oversight
02/05/2026
Juliet Gallagher
On February 3, 2026, President Donald Trump signed a broad government funding package that includes multi-year extensions for Medicare teleath and hospital-at-home programs, new oversight requirements for pharmacy benefit managers (PBMs), and...
On February 3, 2026, President Donald Trump signed a broad government funding package that includes multi-year extensions for Medicare teleath and hospital-at-home programs, new oversight requirements for pharmacy benefit managers (PBMs), and...
On February 3, 2026, President...
02/05/2026
First Report Managed Care
Behind the Bill
The Senate’s $3 Trillion Deal. Tax Relief Now, Medicaid Coverage Loss Later?
07/02/2025
Katie Hayes, MJ
The Senate has done it. After weeks of behind-the-scenes wrangling and last-minute amendments, lawmakers have passed a sprawling tax-and-spending megabill that makes good on a long-standing Republican goal: making the 2017 Trump tax cuts...
The Senate has done it. After weeks of behind-the-scenes wrangling and last-minute amendments, lawmakers have passed a sprawling tax-and-spending megabill that makes good on a long-standing Republican goal: making the 2017 Trump tax cuts...
The Senate has done it. After...
07/02/2025
First Report Managed Care
Behind the Bill
When a Cap Isn’t Just a Cap: How a Provider Tax Proposal Could Reshape Medicaid Financing
06/25/2025
Katie Hayes, MJ
In Washington, the most consequential policies are often buried in the fine print. One such detail in the Senate Finance Committee’s latest tax and spending proposal would gradually cap provider taxes—a core funding tool states use to pull in...
In Washington, the most consequential policies are often buried in the fine print. One such detail in the Senate Finance Committee’s latest tax and spending proposal would gradually cap provider taxes—a core funding tool states use to pull in...
In Washington, the most...
06/25/2025
First Report Managed Care
Behind the Bill
Rewriting the Safety Net? Inside the Senate’s Changes to Medicaid and the ACA
06/18/2025
Katie Hayes, MJ
Over the past few weeks, I’ve been following the progress of the One Big Beautiful Bill Act (OBBBA), which started in the House with sweeping tax reforms and some eye-catching health care proposals. Now, the Senate has released its (highly...
Over the past few weeks, I’ve been following the progress of the One Big Beautiful Bill Act (OBBBA), which started in the House with sweeping tax reforms and some eye-catching health care proposals. Now, the Senate has released its (highly...
Over the past few weeks, I’ve...
06/18/2025
First Report Managed Care
Behind the Bill
How States Might Respond to the One Big Beautiful Bill Act
06/11/2025
Katie Hayes, MJ
With the One Big Beautiful Bill Act (OBBBA) still in the hands of the Senate, much of the national conversation has centered on what this legislation would do to federal coverage programs. But regardless of how the federal process unfolds,...
With the One Big Beautiful Bill Act (OBBBA) still in the hands of the Senate, much of the national conversation has centered on what this legislation would do to federal coverage programs. But regardless of how the federal process unfolds,...
With the One Big Beautiful Bill...
06/11/2025
First Report Managed Care
Behind the Bill
Is the Affordable Care Act on the Chopping Block? What the One Big Beautiful Bill Act Tells Us.
06/04/2025
Katie Hayes, MJ
It’s been weeks of headline-grabbing debate over Medicaid work requirements, and the “One Big Beautiful Bill Act” remains in the Senate as they deliberate over several health care provisions. While the Medicaid provisions sparked most of the...
It’s been weeks of headline-grabbing debate over Medicaid work requirements, and the “One Big Beautiful Bill Act” remains in the Senate as they deliberate over several health care provisions. While the Medicaid provisions sparked most of the...
It’s been weeks of...
06/04/2025
First Report Managed Care
Behind the Bill
From House to Senate: The Journey of Cutting Medicaid
05/28/2025
Katie Hayes, MJ
Last week, the House of Representatives narrowly passed the One Big Beautiful Bill Act (HR 1, 119th Congress) by a single vote, sending the sweeping tax and spending reconciliation package, backed by President Trump, to the Senate. With its...
Last week, the House of Representatives narrowly passed the One Big Beautiful Bill Act (HR 1, 119th Congress) by a single vote, sending the sweeping tax and spending reconciliation package, backed by President Trump, to the Senate. With its...
Last week, the House of...
05/28/2025
First Report Managed Care
Behind the Bill
Eligibility, Paperwork, and Penalties: The Not-So-Hidden Costs of Medicaid ‘Reform’
05/21/2025
Katie Hayes, MJ
It’s been another eventful week in health policy—a phrase that’s quickly becoming routine. This time, House Republicans advanced a sweeping budget reconciliation bill, designed to implement elements of the March budget resolution, with a...
It’s been another eventful week in health policy—a phrase that’s quickly becoming routine. This time, House Republicans advanced a sweeping budget reconciliation bill, designed to implement elements of the March budget resolution, with a...
It’s been another eventful week...
05/21/2025
First Report Managed Care
Behind the Bill
A Busy Week in Drug Pricing Policy: Aligning US Drug Prices With Global Standards?
05/14/2025
Katie Hayes, MJ
It’s been a busy few days for drug pricing policy. While I’d love to dig into the details of both President Trump’s latest executive order and the newest Republican bill that would cut Medicaid spending, we don’t have the time—and this isn’t...
It’s been a busy few days for drug pricing policy. While I’d love to dig into the details of both President Trump’s latest executive order and the newest Republican bill that would cut Medicaid spending, we don’t have the time—and this isn’t...
It’s been a busy few days for...
05/14/2025
First Report Managed Care

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