Tumor Necrosis Factor α Plays a Role in the Pathophysiology of Psoriasis
Identification of the tumor necrosis factor α (TNFα) gene -238G>A polymorphism is associated with an increased incidence of psoriasis, according to a recent study published in the Journal of Cosmetic Dermatology.
Researchers aimed to determine whether the TNFα gene -238G>A polymorphism is associated with psoriasis through a study that comprised 90 patients with psoriasis and 90 healthy control patients. To study the TNFα gene -238G>A polymorphism, investigators extracted genomic DNA and genotyped it using polymerase chain reaction and restriction fragment length polymorphism.
Psoriasis was linked to the AA genotype, and patients with psoriasis had higher frequencies of the A allele and AA genotype. In addition, AA genotype frequency was increased in patients with a family history of psoriasis.
“The TNFα gene -238G>A polymorphism has been related to an increased incidence of psoriasis,” concluded the study authors.
Reference
Akcılar R, Namdar ND, Yükcü F, Arslan Utku S. TNFα gene -238G>A polymorphism is associated with psoriasis patients. J Cosmet Dermatol. Published online March 27, 2022. doi:10.1111/jocd.14940
