(#38) Healthcare Resource Utilization 12 Months Following Initiation of Olanzapine/Samidorphan: Real-World Assessment of Patients With Bipolar I Disorder

Abstract: OBJECTIVE: Combination olanzapine and samidorphan (OLZ/SAM) provides the antipsychotic efficacy of olanzapine while mitigating olanzapine-associated weight gain. OLZ/SAM treatment was associated with significant reductions in acute healthcare resource utilization (HCRU) in a previous 6-month pre/post study. This study examined HCRU among patients with bipolar I disorder (BD-I) in the 12 months before and after OLZ/SAM initiation. METHODS: Administrative claims data from October 18, 2020, to December 31, 2023, from Komodoís Healthcare Map were analyzed retrospectively. Adults with BD-I and continuous enrollment ?12 months before (baseline) and after (follow-up) OLZ/SAM initiation were eligible. Inpatient (IP) admissions, emergency department (ED) and outpatient (OP) visits, and average numbers of IP days/patient were compared between baseline and follow-up. A secondary analysis was conducted for patients receiving OLZ/SAM for the full 12-month follow-up period. RESULTS: Patients (n=1004; mean age: 39 years; female: 69%) were on average persistent for 173.7 days. Proportions of patients with ?1 all-cause, mental health (MH)-related, and BD-Iñrelated IP admissions and ED visits significantly decreased between baseline and follow-up (all P