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Mast Cell Activation Disorders

Research Highlights
Omalizumab Reduced Anaphylaxis Burden in Patients With Idiopathic MCAS
06/22/2026
Jessica Garlewicz
Treatment approaches remain variable for idiopathic mast cell activation syndrome because of its rarity and clinical heterogeneity.
Treatment approaches remain variable for idiopathic mast cell activation syndrome because of its rarity and clinical heterogeneity.
Treatment approaches remain...
06/22/2026
Allergy & Immunology
Guidance
New Yardstick Outlines Treatment Approach for MCAS and Indolent Systemic Mastocytosis
06/22/2026
Jessica Garlewicz
Because MCAS and ISM can present with broad, overlapping symptoms, the authors emphasize diagnostic confirmation before initiating a treatment plan.
Because MCAS and ISM can present with broad, overlapping symptoms, the authors emphasize diagnostic confirmation before initiating a treatment plan.
Because MCAS and ISM can present...
06/22/2026
Allergy & Immunology
Research Summary
Case Series Suggests Potential Role for GLP-1 Receptor Agonists in MCAS
06/22/2026
Jessica Garlewicz
The report did not identify a single dominant symptom domain but instead described improvement across multiple manifestations of the syndrome.
The report did not identify a single dominant symptom domain but instead described improvement across multiple manifestations of the syndrome.
The report did not identify a...
06/22/2026
Allergy & Immunology
Gut Check logo
Expert Insights
Gut Check: Jacqueline Squire, MD, on the Gastric Impacts of MCAS
06/19/2026
Brian E. Lacy, PhD, MD; Jacqueline Squire, MD
Drs Jacqueline Squire and Brian Lacy review the challenges of accurately diagnosing mast cell activation syndrome, how it affects the gastrointestinal and other organ systems, and how best to treatment this relatively rare and often...
Drs Jacqueline Squire and Brian Lacy review the challenges of accurately diagnosing mast cell activation syndrome, how it affects the gastrointestinal and other organ systems, and how best to treatment this relatively rare and often...
Drs Jacqueline Squire and Brian...
06/19/2026
Gastroenterology
From Gastroenterology
Research Review
Mast Cell Activation Syndrome Review Highlights Diagnostic Gaps and Research Needs
06/19/2026
Rebecca Mashaw
A recent review underscores substantial uncertainties remain regarding the definition, diagnosis, and underlying biology of MCAS, calling for standardized criteria, better biomarkers, and high-quality prospective research improve diagnostic...
A recent review underscores substantial uncertainties remain regarding the definition, diagnosis, and underlying biology of MCAS, calling for standardized criteria, better biomarkers, and high-quality prospective research improve diagnostic...
A recent review underscores...
06/19/2026
Allergy & Immunology
Guidance
Diagnosis and Management of Mast Cell Activation Disorders: New Clinical Guidance
06/18/2026
Rebecca Mashaw
An expert review highlights the expanding clinical burden of mast cell activation disorders and the need for consistent diagnostic and management strategies.
An expert review highlights the expanding clinical burden of mast cell activation disorders and the need for consistent diagnostic and management strategies.
An expert review highlights the...
06/18/2026
Allergy & Immunology
Research Insights
Global Consensus-2 Criteria Expand Recognition of Mast Cell Activation Syndrome
06/18/2026
Rebecca Mashaw
Six years after introduction of the Consensus-2 diagnostic criteria for mast cell activation syndrome, a new review argues that broader diagnostic recognition has improved identification of patients with mast-cell–mediated disease.
Six years after introduction of the Consensus-2 diagnostic criteria for mast cell activation syndrome, a new review argues that broader diagnostic recognition has improved identification of patients with mast-cell–mediated disease.
Six years after introduction of...
06/18/2026
Allergy & Immunology

Expert Insights

Gut Check logo
Expert Insights
Gut Check: Jacqueline Squire, MD, on the Gastric Impacts of MCAS
06/19/2026
Brian E. Lacy, PhD, MD; Jacqueline Squire, MD
Drs Jacqueline Squire and Brian Lacy review the challenges of accurately diagnosing mast cell activation syndrome, how it affects the gastrointestinal and other organ systems, and how best to treatment this relatively rare and often...
Drs Jacqueline Squire and Brian Lacy review the challenges of accurately diagnosing mast cell activation syndrome, how it affects the gastrointestinal and other organ systems, and how best to treatment this relatively rare and often...
Drs Jacqueline Squire and Brian...
06/19/2026
Gastroenterology
Gut Check logo
Expert Insights
Gut Check: Jacqueline Squire, MD, on the Gastric Impacts of MCAS
06/19/2026
Brian E. Lacy, PhD, MD; Jacqueline Squire, MD
Drs Jacqueline Squire and Brian Lacy review the challenges of accurately diagnosing mast cell activation syndrome, how it affects the gastrointestinal and other organ systems, and how best to treatment this relatively rare and often...
Drs Jacqueline Squire and Brian Lacy review the challenges of accurately diagnosing mast cell activation syndrome, how it affects the gastrointestinal and other organ systems, and how best to treatment this relatively rare and often...
Drs Jacqueline Squire and Brian...
06/19/2026
Gastroenterology
Michael Wechsler
Expert Insights
Michael Wechsler, MD, on Updates to GINA Guidelines for Asthma
06/15/2026
Michael E. Wechsler, MD
Dr Wechsler reviews key updates to the Global Initiative for Asthma (GINA) 2026, including the addition of combination therapies and new biologics, new assessment methods, inhaler techniques, and more.
Dr Wechsler reviews key updates to the Global Initiative for Asthma (GINA) 2026, including the addition of combination therapies and new biologics, new assessment methods, inhaler techniques, and more.
Dr Wechsler reviews key updates...
06/15/2026
Allergy & Immunology
Conference Coverage
Kathryn Peterson, MD, on Diagnosing and Treating Eosinophilic Gastritis
03/25/2026
Kathryn Peterson, MD, MS
Dr Kathryn Peterson provides an overview of her presentation at the American Academy of Allergy, Asthma, and Immunology on eosinophilic gastric diseases other than EoE, including the challenges of diagnosis and options for treatment.
Dr Kathryn Peterson provides an overview of her presentation at the American Academy of Allergy, Asthma, and Immunology on eosinophilic gastric diseases other than EoE, including the challenges of diagnosis and options for treatment.
Dr Kathryn Peterson provides an...
03/25/2026
Allergy & Immunology
Peter Lio
Clinical Insights
Chemical Exposures, Pollen Flares & the Microbiome in Atopic Dermatitis
03/16/2026
Peter Lio, MD, FAAD
Learn how household chemicals, airborne pollutants, and seasonal pollen surges drive atopic dermatitis flares. Dr Peter Lio examines environmental triggers and microbiome disruption in AD for allergists and immunologists.
Learn how household chemicals, airborne pollutants, and seasonal pollen surges drive atopic dermatitis flares. Dr Peter Lio examines environmental triggers and microbiome disruption in AD for allergists and immunologists.
Learn how household chemicals,...
03/16/2026
Allergy & Immunology
RESEARCH INSIGHTS
Thomas Casale, MD, on the Efficacy of Dupilumab for Chronic Spontaneous Urticaria
03/13/2026
Thomas B. Casale, MD
Dr Casale provides an overview of his poster presentation at the American Academy of Allergy, Asthma, and Immunology annual meeting on whether age, gender, BMI, presence of angioedema, or IgE level affected how patients with chronic...
Dr Casale provides an overview of his poster presentation at the American Academy of Allergy, Asthma, and Immunology annual meeting on whether age, gender, BMI, presence of angioedema, or IgE level affected how patients with chronic...
Dr Casale provides an overview...
03/13/2026
Allergy & Immunology
Peter Lio
Expert Insights
Environmental Triggers of Atopic Dermatitis & Seasonal Allergies
03/05/2026
Peter Lio, MD, FAAD; Riya Gandhi, MA
In this interview, Peter Lio, MD, explores how modern environmental exposures—from pollution to lifestyle shifts—are accelerating type 2 inflammation and fueling atopic dermatitis and seasonal allergies in today’s patients.
In this interview, Peter Lio, MD, explores how modern environmental exposures—from pollution to lifestyle shifts—are accelerating type 2 inflammation and fueling atopic dermatitis and seasonal allergies in today’s patients.
In this interview, Peter Lio,...
03/05/2026
Allergy & Immunology
Allen Kaplan
RESEARCH INSIGHTS
Diagnostic Challenges and Clinical Pitfalls in HAE
03/02/2026
Allen P. Kaplan, MD
Dr Allen Kaplan reviews common diagnostic pitfalls in hereditary angioedema, including misinterpretation of complement testing, confusion with histaminergic angioedema, and challenges in identifying HAE with normal C1 inhibitor.
Dr Allen Kaplan reviews common diagnostic pitfalls in hereditary angioedema, including misinterpretation of complement testing, confusion with histaminergic angioedema, and challenges in identifying HAE with normal C1 inhibitor.
Dr Allen Kaplan reviews common...
03/02/2026
Allergy & Immunology
Allen Kaplan
CLINICAL INSIGHTS
Differentiating Hereditary Angioedema From Its Mimics
02/09/2026
Allen P. Kaplan, MD
Allen Kaplan, MD, discusses how to distinguish hereditary angioedema from common angioedema mimics, including histaminergic and ACE inhibitor–associated angioedema.
Allen Kaplan, MD, discusses how to distinguish hereditary angioedema from common angioedema mimics, including histaminergic and ACE inhibitor–associated angioedema.
Allen Kaplan, MD, discusses how...
02/09/2026
Allergy & Immunology
Joy Chang
Expert Insights
Joy Chang, MD, on Step Therapy for EoE: Part 2
02/05/2026
Joy Chang, MD
Dr Joy Chang continues her tutorial on therapy for eosinophilic esophagitis, including options for using dupilimab as step-down therapy for specific patients.
Dr Joy Chang continues her tutorial on therapy for eosinophilic esophagitis, including options for using dupilimab as step-down therapy for specific patients.
Dr Joy Chang continues her...
02/05/2026
Allergy & Immunology
Joy Chang
Conference Insights
Joy Chang, MD, on Step Therapy for EoE: Part 1
01/26/2026
Joy Chang, MD
In this video, Dr Joy Chang begins a two-part discussion on using step-up and step-down therapy in the treatment of eosinophilic esophagitis based on her presentation at the ACG scientific meeting.
In this video, Dr Joy Chang begins a two-part discussion on using step-up and step-down therapy in the treatment of eosinophilic esophagitis based on her presentation at the ACG scientific meeting.
In this video, Dr Joy Chang...
01/26/2026
Allergy & Immunology

Research

Research Summary
Case Series Suggests Potential Role for GLP-1 Receptor Agonists in MCAS
06/22/2026
Jessica Garlewicz
The report did not identify a single dominant symptom domain but instead described improvement across multiple manifestations of the syndrome.
The report did not identify a single dominant symptom domain but instead described improvement across multiple manifestations of the syndrome.
The report did not identify a...
06/22/2026
Allergy & Immunology
Research Review
Mast Cell Activation Syndrome Review Highlights Diagnostic Gaps and Research Needs
06/19/2026
Rebecca Mashaw
A recent review underscores substantial uncertainties remain regarding the definition, diagnosis, and underlying biology of MCAS, calling for standardized criteria, better biomarkers, and high-quality prospective research improve diagnostic...
A recent review underscores substantial uncertainties remain regarding the definition, diagnosis, and underlying biology of MCAS, calling for standardized criteria, better biomarkers, and high-quality prospective research improve diagnostic...
A recent review underscores...
06/19/2026
Allergy & Immunology
Research Insights
Global Consensus-2 Criteria Expand Recognition of Mast Cell Activation Syndrome
06/18/2026
Rebecca Mashaw
Six years after introduction of the Consensus-2 diagnostic criteria for mast cell activation syndrome, a new review argues that broader diagnostic recognition has improved identification of patients with mast-cell–mediated disease.
Six years after introduction of the Consensus-2 diagnostic criteria for mast cell activation syndrome, a new review argues that broader diagnostic recognition has improved identification of patients with mast-cell–mediated disease.
Six years after introduction of...
06/18/2026
Allergy & Immunology
Research Summary
Case Series Suggests Potential Role for GLP-1 Receptor Agonists in MCAS
06/22/2026
Jessica Garlewicz
The report did not identify a single dominant symptom domain but instead described improvement across multiple manifestations of the syndrome.
The report did not identify a single dominant symptom domain but instead described improvement across multiple manifestations of the syndrome.
The report did not identify a...
06/22/2026
Allergy & Immunology
Research Review
Mast Cell Activation Syndrome Review Highlights Diagnostic Gaps and Research Needs
06/19/2026
Rebecca Mashaw
A recent review underscores substantial uncertainties remain regarding the definition, diagnosis, and underlying biology of MCAS, calling for standardized criteria, better biomarkers, and high-quality prospective research improve diagnostic...
A recent review underscores substantial uncertainties remain regarding the definition, diagnosis, and underlying biology of MCAS, calling for standardized criteria, better biomarkers, and high-quality prospective research improve diagnostic...
A recent review underscores...
06/19/2026
Allergy & Immunology
Research Insights
Global Consensus-2 Criteria Expand Recognition of Mast Cell Activation Syndrome
06/18/2026
Rebecca Mashaw
Six years after introduction of the Consensus-2 diagnostic criteria for mast cell activation syndrome, a new review argues that broader diagnostic recognition has improved identification of patients with mast-cell–mediated disease.
Six years after introduction of the Consensus-2 diagnostic criteria for mast cell activation syndrome, a new review argues that broader diagnostic recognition has improved identification of patients with mast-cell–mediated disease.
Six years after introduction of...
06/18/2026
Allergy & Immunology

Interactive Features

In the News

Research Highlights
BTK Inhibition With Rilzabrutinib Improves Symptoms in Uncontrolled Asthma
05/06/2026
Jessica Garlewicz
Researchers found Bruton's tyrosine kinase inhibition was associated with a numerical decrease in loss of asthma control and may represent “a novel mechanism to treat uncontrolled symptomatic asthma.”
Researchers found Bruton's tyrosine kinase inhibition was associated with a numerical decrease in loss of asthma control and may represent “a novel mechanism to treat uncontrolled symptomatic asthma.”
Researchers found Bruton's...
05/06/2026
Allergy & Immunology
Research Review
Remibrutinib Shows Promise in IgE-Mediated Peanut Allergy
04/23/2026
Riya Gandhi, MA
These findings support continued development of remibrutinib as a potential oral therapeutic option for food allergy.
These findings support continued development of remibrutinib as a potential oral therapeutic option for food allergy.
These findings support continued...
04/23/2026
Allergy & Immunology
Research Review
Higher Phytochemical Intake Linked to Improved Pediatric Asthma Outcomes
03/18/2026
Rebecca Mashaw
Among the 150 children with asthma, those with higher Dietary Phytochemical Index intake had significantly better clinical scores and lower levels of inflammation than those in the lowest tertile.
Among the 150 children with asthma, those with higher Dietary Phytochemical Index intake had significantly better clinical scores and lower levels of inflammation than those in the lowest tertile.
Among the 150 children with...
03/18/2026
Allergy & Immunology
Research Summary
Acute Urticaria Incidence Declined During COVID-19
03/18/2026
Jessica Garlewicz
The findings of an analysis underscore the potential role of common viral infections as a trigger for AU and offer insight into changing disease patterns during the COVID-19 pandemic.
The findings of an analysis underscore the potential role of common viral infections as a trigger for AU and offer insight into changing disease patterns during the COVID-19 pandemic.
The findings of an analysis...
03/18/2026
Allergy & Immunology
Emerging Therapies
Advances in HAE Therapeutics Highlight Path Toward Personalized, Patient-Centered Care
03/02/2026
Jessica Garlewicz
The future of HAE management will likely focus on tailoring regimens to patient-specific needs, attack phenotypes, and treatment goals.
The future of HAE management will likely focus on tailoring regimens to patient-specific needs, attack phenotypes, and treatment goals.
The future of HAE management...
03/02/2026
Allergy & Immunology
FDA Alert
FDA Approves Twice-Yearly Biologic for Severe Eosinophilic Asthma
02/18/2026
Jessica Garlewicz
Exdensur is the first ultra-long-acting biologic for this population, with a dosing schedule of just twice per year.
Exdensur is the first ultra-long-acting biologic for this population, with a dosing schedule of just twice per year.
Exdensur is the first...
02/18/2026
Allergy & Immunology
Research Review
MDD in Asthma Patients Associated With Worse Outcomes in Older Adults
01/29/2026
Rebecca Mashaw
A recent cohort study by highlights how psychological health influences asthma control and healthcare utilization, underscoring a need for integrated care in older populations.
A recent cohort study by highlights how psychological health influences asthma control and healthcare utilization, underscoring a need for integrated care in older populations.
A recent cohort study by...
01/29/2026
Allergy & Immunology
Research Summary
Barriers to Normalization Persist for U.S. Patients With Hereditary Angioedema
01/18/2026
Rebecca Mashaw
New survey data highlight persistent disease burden, frequent attacks, and widespread concern about lifelong medication use among patients being treated for hereditary angioedema.
New survey data highlight persistent disease burden, frequent attacks, and widespread concern about lifelong medication use among patients being treated for hereditary angioedema.
New survey data highlight...
01/18/2026
Allergy & Immunology
Comorbidities
Oscillometry-Based Markers Reveal Airway Dynamics in Asthma–OSA Overlap
12/06/2025
Jessica Garlewicz
While the exact mechanistic interactions remain complex, oscillometric patterns provided insight into changes in respiratory rhythm and resistance related to nocturnal airway collapse and remodeling.
While the exact mechanistic interactions remain complex, oscillometric patterns provided insight into changes in respiratory rhythm and resistance related to nocturnal airway collapse and remodeling.
While the exact mechanistic...
12/06/2025
Allergy & Immunology
Morbidity & Mortality
Mortality From Coexisting Asthma and Cardiovascular Disease Rising
12/06/2025
Jessica Garlewicz
This analysis found significant disparities in mortality across demographic groups.
This analysis found significant disparities in mortality across demographic groups.
This analysis found significant...
12/06/2025
Allergy & Immunology

Popular Articles

Sacha Gnjatic headshot on white background
Clinical Insights
Unraveling Immune Biomarkers in Endometrial Cancer Therapy
05/07/2025
Sacha Gnjatic, PhD
A guest expert discusses groundbreaking research from a national immunotherapy network aimed at identifying biomarkers that predict response to cancer treatments, with a focus on endometrial cancer and novel drug combinations.
A guest expert discusses groundbreaking research from a national immunotherapy network aimed at identifying biomarkers that predict response to cancer treatments, with a focus on endometrial cancer and novel drug combinations.
A guest expert discusses...
05/07/2025
Journal of Clinical Pathways
Peter Lio
Expert Insights
Environmental Triggers of Atopic Dermatitis & Seasonal Allergies
03/05/2026
Peter Lio, MD, FAAD; Riya Gandhi, MA
In this interview, Peter Lio, MD, explores how modern environmental exposures—from pollution to lifestyle shifts—are accelerating type 2 inflammation and fueling atopic dermatitis and seasonal allergies in today’s patients.
In this interview, Peter Lio, MD, explores how modern environmental exposures—from pollution to lifestyle shifts—are accelerating type 2 inflammation and fueling atopic dermatitis and seasonal allergies in today’s patients.
In this interview, Peter Lio,...
03/05/2026
Allergy & Immunology
Research Review
Oral Therapies Expand Options for Personalized Management of Hereditary Angioedema
03/18/2026
Jessica Garlewicz
This analysis highlights the emergence of oral agents as a practical alternative to parenteral therapies for both prophylaxis and acute attack management
This analysis highlights the emergence of oral agents as a practical alternative to parenteral therapies for both prophylaxis and acute attack management
This analysis highlights the...
03/18/2026
Allergy & Immunology
Research Review
Drug-Related Anaphylaxis Mortality Remains Stable but Disparities Persist
11/13/2025
Jessica Garlewicz
A new national analysis of death certificate data from 2011 to 2023 reveals that drug-related anaphylaxis continues to be a significant contributor to anaphylaxis-related deaths in the United States, particularly among older adults and...
A new national analysis of death certificate data from 2011 to 2023 reveals that drug-related anaphylaxis continues to be a significant contributor to anaphylaxis-related deaths in the United States, particularly among older adults and...
A new national analysis of death...
11/13/2025
Allergy & Immunology
Quiz
Future Therapies in HAE: What’s Driving Innovation?
03/01/2026
Riya Gandhi, MA
Dive into next-generation treatment strategies in hereditary angioedema in reshaping long-term care.
Dive into next-generation treatment strategies in hereditary angioedema in reshaping long-term care.
Dive into next-generation...
03/01/2026
Allergy & Immunology

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