Poster
30
(#30) Association of Antipsychotic Medication Nonadherence With All-Cause Mortality in Newly Treated Adults With Schizophrenia: A Retrospective Healthcare Claims Study
Abstract: Background: Clinical data support an association between antipsychotic nonadherence and adverse outcomes in schizophrenia; however, the influence of nonadherence on mortality remains unknown.
Methods: The association between antipsychotic nonadherence and all-cause mortality was evaluated using longitudinal claims data (2011ñ2023). Eligible adults had ?2 outpatient claims on separate dates or ?1 inpatient claim with a schizophrenia diagnosis during the 12 months prior to or at index (ie, antipsychotic initiation date). Patient inclusion required ?12 months of continuous pre-index healthcare plan enrollment and no antipsychotic prescriptions or bipolar disorder diagnoses within 12 months pre-index. Adherence levels were defined by cumulative proportion of days covered (PDC): high adherence (?0.80), low/moderate adherence (?0.2 to
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