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Do MIND or Mediterranean diets affect Alzheimer Disease pathology?

07/05/2023

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Quiz
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Can you recall which plasma biomarkers were associated with greater cognitive decline in frontotemporal dementia?
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Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
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07/06/2026
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Higher Parity May Accelerate Preclinical Alzheimer’s Changes in Postmenopausal Women
06/29/2026
Maria Mantas
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
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Research Summary
Frontal Release Signs Linked to Future Dementia Risk in Older Adults
06/17/2026
Maria Mantas
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release...
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Research Summary
Early Ocrelizumab Shows Sustained Long-Term Benefit in Relapsing MS
10/06/2026
Maria Mantas
Treatment with ocrelizumab for up to 10 years was associated with sustained relapse control and minimal disability accrual in patients with relapsing MS, according to phase 3 findings.
Treatment with ocrelizumab for up to 10 years was associated with sustained relapse control and minimal disability accrual in patients with relapsing MS, according to phase 3 findings.
Treatment with ocrelizumab for...
10/06/2026
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News
P2Y12 Inhibitors Linked to Worse Intracerebral Hemorrhage Outcomes in Nationwide Study
07/13/2026
Maria Mantas
A nationwide cohort study found that prior use of P2Y12 inhibitors, either alone or combined with aspirin, was associated with more severe presentation and worse hospital outcomes in patients with spontaneous ICH.
A nationwide cohort study found that prior use of P2Y12 inhibitors, either alone or combined with aspirin, was associated with more severe presentation and worse hospital outcomes in patients with spontaneous ICH.
A nationwide cohort study found...
07/13/2026
Neurology
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News
Plasma p-tau217/Aβ42 Test Accuracy Reduced in Patients With Traumatic Brain Injury
07/06/2026
Maria Mantas
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio...
07/06/2026
Neurology
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News
Higher Parity May Accelerate Preclinical Alzheimer’s Changes in Postmenopausal Women
06/29/2026
Maria Mantas
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports...
06/29/2026
Neurology
an older woman sits on a couch looking out the window
Research Summary
Frontal Release Signs Linked to Future Dementia Risk in Older Adults
06/17/2026
Maria Mantas
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release...
06/17/2026
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News
Reperfusion-Guided Blood Pressure Strategy May Improve Stroke Outcomes
06/09/2026
Maria Mantas
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized...
06/09/2026
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News
SKY-0515 Shows Sustained Biomarker Reductions in Huntington’s Disease
06/01/2026
Maria Mantas
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational...
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Accelerometer Sleep Metrics Linked to Dementia Risk in Older Adults
05/26/2026
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Disruptions in sleep-wake cycles may provide scalable early markers for dementia risk in older adults, according to cohort study findings.
Disruptions in sleep-wake cycles may provide scalable early markers for dementia risk in older adults, according to cohort study findings.
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Plasma Biomarkers Predict Cognitive Decline in Early-Onset Dementia
05/11/2026
Maria Mantas
In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
In a South Korea–based...
05/11/2026
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Cognitive Decline May Precede Cardiovascular Events in Older Adults
05/04/2026
Maria Mantas
Findings from a large Aspirin in Reducing Events in the Elderly (ASPREE) cohort suggest cognitive changes could serve as early indicators of cardiovascular risk. 
Findings from a large Aspirin in Reducing Events in the Elderly (ASPREE) cohort suggest cognitive changes could serve as early indicators of cardiovascular risk. 
Findings from a large Aspirin in...
05/04/2026
Neurology

Alzheimer's Disease CME Series

Emerging Treatments for Early Alzheimer Disease: Efficacy and Safety Data
11/17/2020
Emerging Treatments for Early Alzheimer Disease: Efficacy and Safety Data To view accreditation information/faculty disclosures for the program, click 
Emerging Treatments for Early Alzheimer Disease: Efficacy and Safety Data To view accreditation information/faculty disclosures for the program, click 
Emerging Treatments for Early...
11/17/2020
Neurology

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