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General Neurology

a strand of RNA
News
SKY-0515 Shows Sustained Biomarker Reductions in Huntington’s Disease
06/01/2026
Maria Mantas
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational...
06/01/2026
Neurology
A person holds a cannabis joint in their hands
News
Cannabis Use in Youth Tied to Altered Cognitive Trajectories
04/21/2026
Brionna Mendoza
A large US longitudinal study published in Neuropsychopharmacology found that adolescents who initiated cannabis use showed flatter neurocognitive development over time than peers who did not use cannabis.
A large US longitudinal study published in Neuropsychopharmacology found that adolescents who initiated cannabis use showed flatter neurocognitive development over time than peers who did not use cannabis.
A large US longitudinal study...
04/21/2026
Psych Congress Network
FDA approval stamp
FDA Alerts
FDA Approves Tividenofusp Alfa-eknm for Neurologic Manifestations of Hunter Syndrome
03/25/2026
Maria Mantas
The US Food and Drug Administration (FDA) has approved Denali Therapeutics’ tividenofusp alfa-eknm (Avlayah) for treating neurologic manifestations of Hunter syndrome.
The US Food and Drug Administration (FDA) has approved Denali Therapeutics’ tividenofusp alfa-eknm (Avlayah) for treating neurologic manifestations of Hunter syndrome.
The US Food and Drug...
03/25/2026
Neurology
broken DNA strand
News
Gene Therapy May Offer an Effective Alternative to Cochlear Implantation in Patients With Congenital Deafness
07/25/2025
Maria Mantas
Patients with congenital deafness who received OTOF gene therapy saw stable hearing recovery and faster improvements in auditory and speech performance than those who had received cochlear implantation.
Patients with congenital deafness who received OTOF gene therapy saw stable hearing recovery and faster improvements in auditory and speech performance than those who had received cochlear implantation.
Patients with congenital...
07/25/2025
Neurology
Doctors examine brain scans
News
GLP-1 RAs May Offer Novel Approach for Idiopathic Intracranial Hypertension Management
07/21/2025
Jolynn Tumolo
Patients with idiopathic intracranial hypertension (IIH) treated with glucagon-like peptide 1 receptor agonists (GLP-1 RAs) had lower medication use, fewer symptoms, and a reduced need for procedural interventions.
Patients with idiopathic intracranial hypertension (IIH) treated with glucagon-like peptide 1 receptor agonists (GLP-1 RAs) had lower medication use, fewer symptoms, and a reduced need for procedural interventions.
Patients with idiopathic...
07/21/2025
Neurology
Marwan Sabbagh, MD, FAAN, FANA
Conference Coverage
Alzheimer's Disease and Cognitive Disorders Symposium: Agenda Highlights
07/17/2025
Marwan Sabbagh, MD
Learn more about the Alzheimer's Disease and Cognitive Disorder Symposium with this video from Co-Chair Marwan Sabbagh, MD, FAAN, FANA.
Learn more about the Alzheimer's Disease and Cognitive Disorder Symposium with this video from Co-Chair Marwan Sabbagh, MD, FAAN, FANA.
Learn more about the Alzheimer's...
07/17/2025
Neurology
Agronin-Jackson-Thumbnail.png
Conference Coverage
Introducing the Alzheimer's Disease and Cognitive Disorders Symposium
07/07/2025
Marc E. Agronin, MD; W. Clay Jackson, MD, DipTh
Meeting co-chairs Marc Agronin and W. Clay Jackson introduce this new symposium and share why healthcare providers should attend.
Meeting co-chairs Marc Agronin and W. Clay Jackson introduce this new symposium and share why healthcare providers should attend.
Meeting co-chairs Marc Agronin...
07/07/2025
Neurology
An orange prescription container with generic pills spilling out in front of it
News
Association Found Between Psychiatric Medication Use and Risk of ALS
06/18/2025
Brionna Mendoza
A case-control study has identified a potential link between use of certain psychiatric medications and the risk and progression of amyotrophic lateral sclerosis (ALS). Findings were published in JAMA Network Open.
A case-control study has identified a potential link between use of certain psychiatric medications and the risk and progression of amyotrophic lateral sclerosis (ALS). Findings were published in JAMA Network Open.
A case-control study has...
06/18/2025
Neurology
diagnosing brain injury
News
Intensive Blood Pressure Reduction After ICH Not Linked to Ischemic Lesions
04/28/2025
Meagan Thistle
Intensive systolic blood pressure (SBP) lowering after intracerebral hemorrhage (ICH) does not increase the risk of ischemic brain injury, according to a new randomized clinical trial.
Intensive systolic blood pressure (SBP) lowering after intracerebral hemorrhage (ICH) does not increase the risk of ischemic brain injury, according to a new randomized clinical trial.
Intensive systolic blood...
04/28/2025
Neurology
A new mom sits on the couch holding her infant, and her forehead
News
Gestational Hypertension, Preeclampsia, and Eclampsia Associated With Greater Incidence of Future Neurological Disorders
02/13/2025
Brionna Mendoza
A recent Swedish cohort study of primiparous women found that those who experienced gestational hypertension, preeclampsia, and eclampsia were at increased risk for new-onset neurological disorders months or years after giving birth.
A recent Swedish cohort study of primiparous women found that those who experienced gestational hypertension, preeclampsia, and eclampsia were at increased risk for new-onset neurological disorders months or years after giving birth.
A recent Swedish cohort study of...
02/13/2025
Neurology

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Neurology Learning Network is an online resource for the latest developments in clinical practice, providing a customized experience for readers to stay informed about the topics that matter most to them.

We are also the official media partner of Alzheimer's Disease and Cognitive Disorders Symposium

News

a strand of RNA
News
SKY-0515 Shows Sustained Biomarker Reductions in Huntington’s Disease
06/01/2026
Maria Mantas
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational...
06/01/2026
Neurology
broken DNA strand
News
Gene Therapy May Offer an Effective Alternative to Cochlear Implantation in Patients With Congenital Deafness
07/25/2025
Maria Mantas
Patients with congenital deafness who received OTOF gene therapy saw stable hearing recovery and faster improvements in auditory and speech performance than those who had received cochlear implantation.
Patients with congenital deafness who received OTOF gene therapy saw stable hearing recovery and faster improvements in auditory and speech performance than those who had received cochlear implantation.
Patients with congenital...
07/25/2025
Neurology
Doctors examine brain scans
News
GLP-1 RAs May Offer Novel Approach for Idiopathic Intracranial Hypertension Management
07/21/2025
Jolynn Tumolo
Patients with idiopathic intracranial hypertension (IIH) treated with glucagon-like peptide 1 receptor agonists (GLP-1 RAs) had lower medication use, fewer symptoms, and a reduced need for procedural interventions.
Patients with idiopathic intracranial hypertension (IIH) treated with glucagon-like peptide 1 receptor agonists (GLP-1 RAs) had lower medication use, fewer symptoms, and a reduced need for procedural interventions.
Patients with idiopathic...
07/21/2025
Neurology
An orange prescription container with generic pills spilling out in front of it
News
Association Found Between Psychiatric Medication Use and Risk of ALS
06/18/2025
Brionna Mendoza
A case-control study has identified a potential link between use of certain psychiatric medications and the risk and progression of amyotrophic lateral sclerosis (ALS). Findings were published in JAMA Network Open.
A case-control study has identified a potential link between use of certain psychiatric medications and the risk and progression of amyotrophic lateral sclerosis (ALS). Findings were published in JAMA Network Open.
A case-control study has...
06/18/2025
Neurology
diagnosing brain injury
News
Intensive Blood Pressure Reduction After ICH Not Linked to Ischemic Lesions
04/28/2025
Meagan Thistle
Intensive systolic blood pressure (SBP) lowering after intracerebral hemorrhage (ICH) does not increase the risk of ischemic brain injury, according to a new randomized clinical trial.
Intensive systolic blood pressure (SBP) lowering after intracerebral hemorrhage (ICH) does not increase the risk of ischemic brain injury, according to a new randomized clinical trial.
Intensive systolic blood...
04/28/2025
Neurology
A new mom sits on the couch holding her infant, and her forehead
News
Gestational Hypertension, Preeclampsia, and Eclampsia Associated With Greater Incidence of Future Neurological Disorders
02/13/2025
Brionna Mendoza
A recent Swedish cohort study of primiparous women found that those who experienced gestational hypertension, preeclampsia, and eclampsia were at increased risk for new-onset neurological disorders months or years after giving birth.
A recent Swedish cohort study of primiparous women found that those who experienced gestational hypertension, preeclampsia, and eclampsia were at increased risk for new-onset neurological disorders months or years after giving birth.
A recent Swedish cohort study of...
02/13/2025
Neurology
A person holds a cannabis joint in their hands
News
Cannabis Use Linked With Diminished Brain Activation in Young Adults
02/11/2025
Jolynn Tumolo
A lifetime history of heavy cannabis use in young adults was associated with lower brain activation during a working memory task, according to a study in JAMA Network Open
A lifetime history of heavy cannabis use in young adults was associated with lower brain activation during a working memory task, according to a study in JAMA Network Open
A lifetime history of heavy...
02/11/2025
Neurology
Intensive Blood Pressure Control Lowers Cognitive Impairment Risk Years Later
News
Intensive Blood Pressure Control Lowers Cognitive Impairment Risk Years Later
02/05/2025
Jolynn Tumolo
Just over 3 years of intensive treatment to reduce systolic blood pressure in adults with hypertension and high cardiovascular risk resulted in a lower rate of cognitive impairment 7 years later, according to a study published in Neurology.
Just over 3 years of intensive treatment to reduce systolic blood pressure in adults with hypertension and high cardiovascular risk resulted in a lower rate of cognitive impairment 7 years later, according to a study published in Neurology.
Just over 3 years of intensive...
02/05/2025
Neurology
Researchers Report Best Times for Biomarker Assessment After NMOSD Attacks
News
Researchers Report Best Times for Biomarker Assessment After NMOSD Attacks
02/03/2025
Jolynn Tumolo
The optimal times to assess sGFAP and sNfL when evaluating attacks in patients with neuromyelitis optica spectrum disorder (NMOSD) were within 1 week for sGFAP and 1 to 8 weeks for sNfL, according to study results published in JAMA Neurology.
The optimal times to assess sGFAP and sNfL when evaluating attacks in patients with neuromyelitis optica spectrum disorder (NMOSD) were within 1 week for sGFAP and 1 to 8 weeks for sNfL, according to study results published in JAMA Neurology.
The optimal times to assess...
02/03/2025
Neurology
Brain health
News
Mood Changes May Be a Prodromal Symptom in Sporadic Creutzfeldt-Jakob Disease
01/09/2025
Brionna Mendoza
Mood changes may precede symptom onset in sporadic Creutzfeldt-Jakob disease (sCJD) as early as 3 years, according to the findings from a retrospective case-control study published in JAMA Neurology.
Mood changes may precede symptom onset in sporadic Creutzfeldt-Jakob disease (sCJD) as early as 3 years, according to the findings from a retrospective case-control study published in JAMA Neurology.
Mood changes may precede symptom...
01/09/2025
Neurology
a patient laying in a hospital bed holds hands with a healthcare provider
Research Summary
Hospital-Associated Delirium Linked to Worse Cognitive Trajectories
11/04/2026
Maria Mantas
Delirium documented within 30 days of hospitalization was associated with a significantly higher risk of mild cognitive impairment and dementia, according to longitudinal cohort findings.
Delirium documented within 30 days of hospitalization was associated with a significantly higher risk of mild cognitive impairment and dementia, according to longitudinal cohort findings.
Delirium documented within 30...
11/04/2026
Neurology
older adult resting hands on cane
Research Summary
Vascular Risk Factors Associated With Late-Onset Epilepsy in Older Adults
10/22/2026
Maria Mantas
Several vascular risk factors, including smoking, hypertension, diabetes and prior stroke, were associated with LOE in older adults, according to pooled analysis findings.
Several vascular risk factors, including smoking, hypertension, diabetes and prior stroke, were associated with LOE in older adults, according to pooled analysis findings.
Several vascular risk factors,...
10/22/2026
Neurology
trees with leaves falling to represent dementia progression
News
Global Dementia Cases Projected to Double by 2050
10/15/2026
Maria Mantas
A meta-analysis of 38,418 participants across 18 countries or territories estimated 11.4 million new dementia cases globally in 2023, with annual incidence projected to reach 24.7 million by 2050.
A meta-analysis of 38,418 participants across 18 countries or territories estimated 11.4 million new dementia cases globally in 2023, with annual incidence projected to reach 24.7 million by 2050.
A meta-analysis of 38,418...
10/15/2026
Neurology
a physician fills out a discharge form while speaking to a patient
Research Summary
Early Ocrelizumab Shows Sustained Long-Term Benefit in Relapsing MS
10/06/2026
Maria Mantas
Treatment with ocrelizumab for up to 10 years was associated with sustained relapse control and minimal disability accrual in patients with relapsing MS, according to phase 3 findings.
Treatment with ocrelizumab for up to 10 years was associated with sustained relapse control and minimal disability accrual in patients with relapsing MS, according to phase 3 findings.
Treatment with ocrelizumab for...
10/06/2026
Neurology
a hand points to a specific spot on a brain scan
News
P2Y12 Inhibitors Linked to Worse Intracerebral Hemorrhage Outcomes in Nationwide Study
07/13/2026
Maria Mantas
A nationwide cohort study found that prior use of P2Y12 inhibitors, either alone or combined with aspirin, was associated with more severe presentation and worse hospital outcomes in patients with spontaneous ICH.
A nationwide cohort study found that prior use of P2Y12 inhibitors, either alone or combined with aspirin, was associated with more severe presentation and worse hospital outcomes in patients with spontaneous ICH.
A nationwide cohort study found...
07/13/2026
Neurology
a researcher holds up a test tube of blood
News
Plasma p-tau217/Aβ42 Test Accuracy Reduced in Patients With Traumatic Brain Injury
07/06/2026
Maria Mantas
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
Plasma p-tau217/Aβ42 ratio...
07/06/2026
Neurology
doctor holds hands with an older woman patient sitting on the couch
News
Higher Parity May Accelerate Preclinical Alzheimer’s Changes in Postmenopausal Women
06/29/2026
Maria Mantas
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
A longitudinal study reports...
06/29/2026
Neurology
an older woman sits on a couch looking out the window
Research Summary
Frontal Release Signs Linked to Future Dementia Risk in Older Adults
06/17/2026
Maria Mantas
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release...
06/17/2026
Neurology
a doctor reviews brain scans
News
Reperfusion-Guided Blood Pressure Strategy May Improve Stroke Outcomes
06/09/2026
Maria Mantas
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized...
06/09/2026
Neurology
a strand of RNA
News
SKY-0515 Shows Sustained Biomarker Reductions in Huntington’s Disease
06/01/2026
Maria Mantas
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational...
06/01/2026
Neurology

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