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How many years of PPI use increased dementia risk?

09/28/2023

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Quiz
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Can you recall which plasma biomarkers were associated with greater cognitive decline in frontotemporal dementia?
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Treatment with ocrelizumab for up to 10 years was associated with sustained relapse control and minimal disability accrual in patients with relapsing MS, according to phase 3 findings.
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P2Y12 Inhibitors Linked to Worse Intracerebral Hemorrhage Outcomes in Nationwide Study
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A nationwide cohort study found that prior use of P2Y12 inhibitors, either alone or combined with aspirin, was associated with more severe presentation and worse hospital outcomes in patients with spontaneous ICH.
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Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
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Higher Parity May Accelerate Preclinical Alzheimer’s Changes in Postmenopausal Women
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A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
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Frontal Release Signs Linked to Future Dementia Risk in Older Adults
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In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
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Alzheimer's Disease CME Series

Emerging Treatments for Early Alzheimer Disease: Efficacy and Safety Data
11/17/2020
Emerging Treatments for Early Alzheimer Disease: Efficacy and Safety Data To view accreditation information/faculty disclosures for the program, click 
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