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Major Depressive Disorder News

Head in profile with brain visible and target over brain
Research Summary
10/08/2026
A connectivity-guided approach to accelerated iTBS produced greater short-term reductions in depression severity than conventional scalp-based targeting.
A connectivity-guided approach to accelerated iTBS produced greater short-term reductions in depression severity than conventional scalp-based targeting.
A connectivity-guided approach...
10/08/2026
Psych Congress Network
A selection of ultraprocessed foods, including donuts, hamburgers, pizza, and fries.
News
09/25/2026
Brionna Mendoza
Reducing ultraprocessed food consumption was feasible and acceptable among adults with major depressive disorder (MDD) and was associated with lower depression and anxiety scores.
Reducing ultraprocessed food consumption was feasible and acceptable among adults with major depressive disorder (MDD) and was associated with lower depression and anxiety scores.
Reducing ultraprocessed food...
09/25/2026
Psych Congress Network
older woman with depression
Research Summary
09/23/2026
Maria Mantas
Vortioxetine was consistently associated with reduced depressive symptoms in older adults with MDD, while its effects on cognition were less consistent, according to a systematic review.
Vortioxetine was consistently associated with reduced depressive symptoms in older adults with MDD, while its effects on cognition were less consistent, according to a systematic review.
Vortioxetine was consistently...
09/23/2026
Psych Congress Network
fda building sign
News
09/09/2026
Brionna Mendoza
The US FDA has granted Breakthrough Therapy designation to DT120, an orally disintegrating lysergide tablet, for the treatment of MDD.
The US FDA has granted Breakthrough Therapy designation to DT120, an orally disintegrating lysergide tablet, for the treatment of MDD.
The US FDA has granted...
09/09/2026
Psych Congress Network
a woman holds her head in her hands
Research Summary
09/01/2026
Maria Mantas
Negative expectations about the future were associated with differences in brain structure and a longer course of depressive illness among patients with MDD.
Negative expectations about the future were associated with differences in brain structure and a longer course of depressive illness among patients with MDD.
Negative expectations about the...
09/01/2026
Psych Congress Network
A pregnant woman attends her doctor's appointment
News
08/18/2026
Brionna Mendoza
Treating MDD during pregnancy should be prioritized as part of maternal and fetal health care, argued the authors of a Special Communication published in JAMA Psychiatry.
Treating MDD during pregnancy should be prioritized as part of maternal and fetal health care, argued the authors of a Special Communication published in JAMA Psychiatry.
Treating MDD during pregnancy...
08/18/2026
Psych Congress Network
a worried woman looks out a window
Research Summary
08/14/2026
Maria Mantas
In a preregistered study of 106 adults, individuals with major depressive disorder (MDD) reported more mind-wandering than healthy controls during a continuous performance task.
In a preregistered study of 106 adults, individuals with major depressive disorder (MDD) reported more mind-wandering than healthy controls during a continuous performance task.
In a preregistered study of 106...
08/14/2026
Psych Congress Network
a man smokes a cigarette
Research Summary
08/13/2026
Maria Mantas
Baseline alcohol, nicotine, and cannabis use was largely not associated with antidepressant response to rTMS among patients with MDD, according to study findings.
Baseline alcohol, nicotine, and cannabis use was largely not associated with antidepressant response to rTMS among patients with MDD, according to study findings.
Baseline alcohol, nicotine, and...
08/13/2026
Psych Congress Network
illustration of a brain
Research Summary
07/21/2026
Maria Mantas
Patients with TRD receiving repeated, low-dose oral esketamine did not experience greater increases in serum BDNF than those receiving placebo, according to study findings.
Patients with TRD receiving repeated, low-dose oral esketamine did not experience greater increases in serum BDNF than those receiving placebo, according to study findings.
Patients with TRD receiving...
07/21/2026
Psych Congress Network
a stethoscope, pills, and brain
Research Summary
07/16/2026
Maria Mantas
Patients with MDD and favorable biobehavioral markers for sertraline and/or bupropion experienced higher antidepressant response rates than those with negative markers for both drugs.
Patients with MDD and favorable biobehavioral markers for sertraline and/or bupropion experienced higher antidepressant response rates than those with negative markers for both drugs.
Patients with MDD and favorable...
07/16/2026
Psych Congress Network