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Chronic Total Occlusion Topic Center Original Contribution

Review
02/17/2026
Semih Ceylan; Deniz Mutlu, MD; Eleni Kladou, MD; Nick Williford, MD; Sandeep Jalli, MD; Ahmed Al-Ogaili, MD; Masahisa Yamane, MD; Khaldoon Alaswad, MD; Allison Hall, MD; Rhian Davies, DO; James W. Choi, MD; Andrea Gagnor, MD; Roberto Garbo, MD; Omer Goktekin, MD; Sevket Gorgulu, MD; Jaikirshan J. Khatri, MD; William Nicholson, MD; Stéphane Rinfret, MD; Wissam Jaber, MD; Mohaned Egred, MD; Anastasios Milkas, MD, PhD; Niccolò Ciardetti, MD; Carlo Di Mario, MD, PhD; Kambis Mashayekhi, MD, PhD; Alexandre Avran, MD; Gregor Leibundgut, MD; Yiannis S. Chatzizisis, MD, PhD; Gerald S. Werner, MD, PhD; Claudiu Ungureanu, MD; Yader Sandoval, MD; Emmanouil S. Brilakis, MD, PhD
This review provides a summary of the published literature in CTO PCI between September 2023 and April 2025, categorized by procedural outcomes, techniques, complications, and ongoing studies.
This review provides a summary of the published literature in CTO PCI between September 2023 and April 2025, categorized by procedural outcomes, techniques, complications, and ongoing studies.
This review provides a summary...
02/17/2026
Journal of Invasive Cardiology
Original Contribution
05/17/2025
Dimitrios Strepkos, MD; Athanasios Rempakos, MD; Michaella Alexandrou, MD; Deniz Mutlu, MD; Pedro E.P. Carvalho, MD; Ozgur Selim Ser, MD; Khaldoon Alaswad, MD; Mir Babar Basir, DO; Dmitrii Khelimskii, MD; Oleg Krestyaninov, MD; Jaikirshan J. Khatri, MD; Laura D. Young, MD; Omer Goktekin, MD; Paul Poommipanit, MD; Farouc A. Jaffer, MD, PhD; Sevket Gorgulu, MD; Ahmed M. ElGuindy, MD; Nidal Abi Rafeh, MD; Olga C. Mastrodemos, BA; Bavana V. Rangan, BDS, MPH; Sandeep Jalli, DO; Konstantinos Voudris, MD, PhD; Yader Sandoval, MD; M. Nicholas Burke, MD; Emmanouil S. Brilakis, MD, PhD
The impact of contrast type in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) remains controversial. The authors sought to evaluate the impact of contrast medium selection on patients undergoing CTO PCI.
The impact of contrast type in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) remains controversial. The authors sought to evaluate the impact of contrast medium selection on patients undergoing CTO PCI.
The impact of contrast type in...
05/17/2025
Journal of Invasive Cardiology
Review
05/13/2025
Athanasios Rempakos, MD; Pranathi Pilla, BSc; Michaella Alexandrou, MD; Deniz Mutlu, MD; Dimitrios Strepkos, MD; Pedro E.P. Carvalho, MD; Ozgur Selim Ser, MD; Ali Bahbah, MD; Amit Amin, MD; Anand Prasad, MD; Lorenzo Azzalini, MD, PhD; Luiz F. Ybarra, MD; Olga C. Mastrodemos, BA; Bavana V. Rangan, BDS, MPH; Ahmed Al-Ogaili, MD; Sandeep Jalli, DO; M. Nicholas Burke, MD; Yader Sandoval, MD; Emmanouil S. Brilakis, MD, PhD
The authors review the latest AI-based innovations in the diagnosis of chronic total occlusions (CTO) and in determining the probability of success of CTO PCI.
The authors review the latest AI-based innovations in the diagnosis of chronic total occlusions (CTO) and in determining the probability of success of CTO PCI.
The authors review the latest...
05/13/2025
Journal of Invasive Cardiology
Original Contribution
03/04/2025
Soichiro Ebisawa, MD, PhD; Etsuo Tsuchikane, MD, PhD; Koichi Kishi, MD; Yoshiaki Ito, MD, PhD; Hisayuki Okada, MD, PhD; Satoru Sumitsuji, MD; Yuji Oikawa, MD; Ryohei Yoshikawa, MD; Hiroyuki Tanaka, MD
This study aimed to compare the strategies and initial success rates of chronic total occlusion-percutaneous coronary intervention in patients with and without prior coronary artery bypass graft.
This study aimed to compare the strategies and initial success rates of chronic total occlusion-percutaneous coronary intervention in patients with and without prior coronary artery bypass graft.
This study aimed to compare the...
03/04/2025
Journal of Invasive Cardiology
Original Contribution
01/13/2025
Deniz Mutlu, MD; Dimitrios Strepkos, MD; Pedro E.P. Carvalho, MD; Michaella Alexandrou, MD; Ahmed Al-Ogaili, MD; Sandeep Jalli, MD; Khaldoon Alaswad, MD; Farouc A. Jaffer, MD; Rhian Davies, DO, MS; Paul Poommipanit, MD; Jarrod Frizzell, MD; Basem Elbarouni, MD; Jaikirshan J. Khatri, MD; Sevket Gorgulu, MD; Omer Goktekin, MD; Ramazan Ozdemir, MD; Mahmut Uluganyan, MD; Ahmed ElGuindy, MD; Yasser Sadek, MD; Yousif Ahmad, BMedSci, BMBS, PhD; Mir B. Basir, MD; Leah Raj, MD; Luiz Ybarra, MD, PhD; Bilal Murad, MD; Bavana V. Rangan, BDS, MPH; Olga C. Mastrodemos, BA; Lorenzo Azzalini, MD, PhD, MSc; Yader Sandoval, MD; M. Nicholas Burke, MD; Emmanouil S. Brilakis, MD, PhD
The authors examined the frequency and outcomes of Ostial Flash balloon use in aorto-ostial chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in a multicenter contemporary CTO-PCI registry.
The authors examined the frequency and outcomes of Ostial Flash balloon use in aorto-ostial chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in a multicenter contemporary CTO-PCI registry.
The authors examined the...
01/13/2025
Journal of Invasive Cardiology
Original Contribution
12/30/2024
Maksymilian P. Opolski, MD, PhD; Antoni Zyśk, MD; Wojciech Skorupski, MD, PhD; Artur Dębski, MD, PhD; Adam Witkowski, MD, PhD
The authors performed a 2-arm randomized controlled trial to compare the time, efficacy and safety outcomes between an antegrade wiring (AW) strategy using a first-choice intermediate tip-load polymer-jacketed guidewire vs an AW strategy...
The authors performed a 2-arm randomized controlled trial to compare the time, efficacy and safety outcomes between an antegrade wiring (AW) strategy using a first-choice intermediate tip-load polymer-jacketed guidewire vs an AW strategy...
The authors performed a 2-arm...
12/30/2024
Journal of Invasive Cardiology
Original Contribution
09/30/2024
Michaella Alexandrou, MD; Athanasios Rempakos, MD; Deniz Mutlu, MD; Dimitrios Strepkos, MD; Pedro E.P. Carvalho, MD; Ahmed Al-Ogaili, MD; Anastasios Milkas, MD; Ioannis Tsiafoutis, MD; Khaldoon Alaswad, MD; Mir Babar Basir, DO; Rhian Davies, DO, MS; Farouc A. Jaffer, MD, PhD; William Nicholson, MD; Lorenzo Azzalini, MD, PhD, MSc; Sevket Gorgulu, MD; Jaikirshan J. Khatri, MD; Sripal Bangalore, MD, MHA; Bavana V. Rangan, BDS, MPH; Olga C. Mastrodemos, BA; M. Nicholas Burke, MD; Yader Sandoval, MD; Emmanouil S. Brilakis, MD, PhD
The authors compared the predictions for successful antegrade wiring of chronic total occlusion lesions made by interventional cardiologists with those from a machine learning model.
The authors compared the predictions for successful antegrade wiring of chronic total occlusion lesions made by interventional cardiologists with those from a machine learning model.
The authors compared the...
09/30/2024
Journal of Invasive Cardiology
Original Contribution
08/19/2024
Louis Verreault-Julien, MD, MPH; Israth Jahan, BSc; Nandini Dendukuri, PhD; Luiz F. Ybarra, MD, MBA; Samer Mansour, MD; Alexis Matteau, MD; Harinda C. Wijeysundera, MD, PhD; Anthony Fung, MBBS; Simon Robinson, MD; Jean-Michel Paradis, MD; Can Manh Nguyen, MD; Stéphane Rinfret, MD, SM
Chronic total occlusion percutaneous coronary intervention can be performed using an antegrade-only approach or a retrograde approach (RA). Whether an RA carries a higher risk of complications needs further investigation.
Chronic total occlusion percutaneous coronary intervention can be performed using an antegrade-only approach or a retrograde approach (RA). Whether an RA carries a higher risk of complications needs further investigation.
Chronic total occlusion...
08/19/2024
Journal of Invasive Cardiology
Original Contribution
08/09/2024
Michaella Alexandrou, MD; Athanasios Rempakos, MD; Deniz Mutlu, MD; Ahmed Al-Ogaili, MD; Pedro E.P. Carvalho, MD; Dimitrios Strepkos, MD; James W. Choi, MD; Paul Poommipanit, MD; Khaldoon Alaswad, MD; Mir Babar Basir, DO; Rhian Davies, DO, MS; Farouc A. Jaffer, MD, PhD; Philip Dattilo, MD; Anthony H. Doing, MD; Lorenzo Azzalini, MD, PhD, MSc; Nazif Aygul, MD; Raj Chandwaney, MD; Brian K. Jefferson, MD; Sevket Gorgulu, MD; Jaikirshan J. Khatri, MD; Laura D. Young, MD; Oleg Krestyaninov, MD; Dmitrii Khelimskii, MD; Jarrod Frizzell, MD; Omer Goktekin, MD; James D. Flaherty, MD; Daniel R. Schimmel, MD, MS; Keith H. Benzuly, MD; Mahmut Uluganyan, MD; Ramazan Ozdemir, MD; Yousif Ahmad, MRCP, PhD, FSCAI, FACC, BMBS; Bavana V. Rangan, BDS, MPH; Olga C. Mastrodemos, BA; M. Nicholas Burke, MD; Konstantinos Voudris, MD; Yader Sandoval, MD; Emmanouil S. Brilakis, MD, PhD
The authors examined a multicenter registry of CTO PCI to explore the prevalence of peripheral artery disease and its effects on techniques used during the procedure and in-hospital outcomes.
The authors examined a multicenter registry of CTO PCI to explore the prevalence of peripheral artery disease and its effects on techniques used during the procedure and in-hospital outcomes.
The authors examined a...
08/09/2024
Journal of Invasive Cardiology
Review
06/03/2024

Eugene B. Wu, MD1; Wataru Nagamatsu, MD2; Atsunori Okamura, MD3

Eugene B. Wu, MD1; Wataru Nagamatsu, ...
In this article, the authors provide 10 tips for every chronic total occlusion interventionist to use when performing 3-dimensional wiring in distal true lumen wiring
In this article, the authors provide 10 tips for every chronic total occlusion interventionist to use when performing 3-dimensional wiring in distal true lumen wiring
In this article, the authors...
06/03/2024
Journal of Invasive Cardiology