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FDA-Approved Options for Pediatric Narcolepsy

08/15/2024

 

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Ali El Sohl, MD, MPH
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Rethinking OSA Management With GLP-1 Receptor Agonists: Part 2
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Ali El Sohl, MD, professor, University of Buffalo, offers further thoughts on the findings of his narrative review exploring GLP-1 receptor agonists (GLP-1 RAs) for management of obstructive sleep apnea (OSA).
Ali El Sohl, MD, professor, University of Buffalo, offers further thoughts on the findings of his narrative review exploring GLP-1 receptor agonists (GLP-1 RAs) for management of obstructive sleep apnea (OSA).
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While regularity in day-to-day sleep patterns appears beneficial for cognitive function, sleep patterns that are rigid or highly regular may not be optimal in terms of serum brain-derived neurotrophic factor (BDNF).
While regularity in day-to-day sleep patterns appears beneficial for cognitive function, sleep patterns that are rigid or highly regular may not be optimal in terms of serum brain-derived neurotrophic factor (BDNF).
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Antipsychotic medications can influence sleep in ways that extend beyond nighttime sedation, creating important considerations for neurologists evaluating patients with daytime fatigue or disrupted sleep.
Antipsychotic medications can influence sleep in ways that extend beyond nighttime sedation, creating important considerations for neurologists evaluating patients with daytime fatigue or disrupted sleep.
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Neurology Learning Network is an online resource for the latest developments in clinical practice, providing a customized experience for readers to stay informed about the topics that matter most to them.

We are also the official media partner of Alzheimer's Disease and Cognitive Disorders Symposium

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Hospital-Associated Delirium Linked to Worse Cognitive Trajectories
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Delirium documented within 30 days of hospitalization was associated with a significantly higher risk of mild cognitive impairment and dementia, according to longitudinal cohort findings.
Delirium documented within 30 days of hospitalization was associated with a significantly higher risk of mild cognitive impairment and dementia, according to longitudinal cohort findings.
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Vascular Risk Factors Associated With Late-Onset Epilepsy in Older Adults
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Several vascular risk factors, including smoking, hypertension, diabetes and prior stroke, were associated with LOE in older adults, according to pooled analysis findings.
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Neurology
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Global Dementia Cases Projected to Double by 2050
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Maria Mantas
A meta-analysis of 38,418 participants across 18 countries or territories estimated 11.4 million new dementia cases globally in 2023, with annual incidence projected to reach 24.7 million by 2050.
A meta-analysis of 38,418 participants across 18 countries or territories estimated 11.4 million new dementia cases globally in 2023, with annual incidence projected to reach 24.7 million by 2050.
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Early Ocrelizumab Shows Sustained Long-Term Benefit in Relapsing MS
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P2Y12 Inhibitors Linked to Worse Intracerebral Hemorrhage Outcomes in Nationwide Study
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A nationwide cohort study found that prior use of P2Y12 inhibitors, either alone or combined with aspirin, was associated with more severe presentation and worse hospital outcomes in patients with spontaneous ICH.
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Plasma p-tau217/Aβ42 Test Accuracy Reduced in Patients With Traumatic Brain Injury
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Plasma p-tau217/Aβ42 ratio accurately detected amyloid-PET positivity in veterans without traumatic brain injury (TBI), but accuracy declined significantly in those with prior TBI. 
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Higher Parity May Accelerate Preclinical Alzheimer’s Changes in Postmenopausal Women
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A longitudinal study reports that parity may modify the relationship between Alzheimer disease (AD) pathology and brain aging in cognitively unimpaired postmenopausal women.
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Frontal Release Signs Linked to Future Dementia Risk in Older Adults
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The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
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Neurology
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Reperfusion-Guided Blood Pressure Strategy May Improve Stroke Outcomes
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A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
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SKY-0515 Shows Sustained Biomarker Reductions in Huntington’s Disease
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SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational...
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Neurology

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