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Alzheimer Disease News

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Research Summary
Frontal Release Signs Linked to Future Dementia Risk in Older Adults
06/17/2026
Maria Mantas
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release...
06/17/2026
Neurology
a man lays in bed unable to sleep
News
Accelerometer Sleep Metrics Linked to Dementia Risk in Older Adults
05/26/2026
Maria Mantas
Disruptions in sleep-wake cycles may provide scalable early markers for dementia risk in older adults, according to cohort study findings.
Disruptions in sleep-wake cycles may provide scalable early markers for dementia risk in older adults, according to cohort study findings.
Disruptions in sleep-wake cycles...
05/26/2026
Neurology
a side profile of a human head, with the top portion appearing to be made of shattered, crumpled paper
News
Plasma Biomarkers Predict Cognitive Decline in Early-Onset Dementia
05/11/2026
Maria Mantas
In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
In a South Korea–based...
05/11/2026
Neurology
an older man wearing a mask receives a vaccination shot in his upper arm
News
High-Dose Flu Vaccine Tied to Lower Alzheimer Risk
04/09/2026
Brionna Mendoza
High-dose influenza vaccination may confer additional neuroprotective benefit beyond standard-dose formulations, according to results from a new, large retrospective cohort study published in Neurology.
High-dose influenza vaccination may confer additional neuroprotective benefit beyond standard-dose formulations, according to results from a new, large retrospective cohort study published in Neurology.
High-dose influenza vaccination...
04/09/2026
Neurology
a bowl of fruits and vegetables indicates brain health
News
DASH Diet Linked to Lower Subjective Cognitive Decline Risk
03/02/2026
Maria Mantas
In a prospective cohort of 159,347 US adults, higher adherence to 6 healthy dietary patterns was associated with lower risk of subjective cognitive decline (SCD).
In a prospective cohort of 159,347 US adults, higher adherence to 6 healthy dietary patterns was associated with lower risk of subjective cognitive decline (SCD).
In a prospective cohort of...
03/02/2026
Neurology
News
Fine Particulate Air Pollution Linked to Greater Alzheimer Neuropathology, Study Finds
12/16/2025
Grace Taylor, MS, MA
Research published in JAMA Neurology links higher exposure to fine particulate air pollution (PM2.5) with more severe Alzheimer-related brain changes and faster cognitive decline in older adults.
Research published in JAMA Neurology links higher exposure to fine particulate air pollution (PM2.5) with more severe Alzheimer-related brain changes and faster cognitive decline in older adults.
Research published in JAMA...
12/16/2025
Annals of Long-Term Care
News
Gabapentin Enacarbil Lowers Nighttime Agitation in Dementia Patients With Restless Legs Syndrome
11/26/2025
Grace Taylor, MS, MA
A randomized trial shows that treating restless legs syndrome with gabapentin enacarbil can significantly reduce nighttime agitation and improve sleep in older adults with Alzheimer disease–related dementia.
A randomized trial shows that treating restless legs syndrome with gabapentin enacarbil can significantly reduce nighttime agitation and improve sleep in older adults with Alzheimer disease–related dementia.
A randomized trial shows that...
11/26/2025
Annals of Long-Term Care
A man lies in bed asleep
News
Moderate to Severe OSA May Raise Risk for Cerebral Microbleeds
11/03/2025
Jolynn Tumolo
Moderate to severe obstructive sleep apnea (OSA) is independently linked with an increased risk of incident cerebral microbleeds (CMBs) over 8 years, according to a population-based study published online in JAMA Network Open.
Moderate to severe obstructive sleep apnea (OSA) is independently linked with an increased risk of incident cerebral microbleeds (CMBs) over 8 years, according to a population-based study published online in JAMA Network Open.
Moderate to severe obstructive...
11/03/2025
Neurology
a neurologist reviews a brain model with a patient
News
Posttreatment Amyloid Levels Associated With Donanemab Benefit in Early AD
10/28/2025
Jolynn Tumolo
An exploratory post hoc analysis of a randomized clinical trial that demonstrated clinical benefit with donanemab in patients with early symptomatic Alzheimer disease (AD) suggests amyloid plaque removal was the mechanism of action.
An exploratory post hoc analysis of a randomized clinical trial that demonstrated clinical benefit with donanemab in patients with early symptomatic Alzheimer disease (AD) suggests amyloid plaque removal was the mechanism of action.
An exploratory post hoc analysis...
10/28/2025
Neurology
A doctor clasps an elderly woman's hand between her own alzheimer's cognitive impairment
News
Metabolic Modulators Show Promise in Early Alzheimer Disease
10/21/2025
Jolynn Tumolo
Intranasal insulin and the diabetes drug empagliflozin were safe and demonstrated positive effects on memory, brain health, and brain blood flow in patients with mild cognitive impairment (MCI) and early Alzheimer disease (AD).
Intranasal insulin and the diabetes drug empagliflozin were safe and demonstrated positive effects on memory, brain health, and brain blood flow in patients with mild cognitive impairment (MCI) and early Alzheimer disease (AD).
Intranasal insulin and the...
10/21/2025
Neurology

Migraine CME Series

News

an older woman sits on a couch looking out the window
Research Summary
Frontal Release Signs Linked to Future Dementia Risk in Older Adults
06/17/2026
Maria Mantas
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release signs (FRS), primitive reflexes that reemerge with neurodegeneration or brain injury, may help identify older adults at increased risk for future cognitive decline, according to a cohort study.
The presence of frontal release...
06/17/2026
Neurology
a doctor reviews brain scans
News
Reperfusion-Guided Blood Pressure Strategy May Improve Stroke Outcomes
06/09/2026
Maria Mantas
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized clinical trial found that reperfusion-guided systolic blood pressure (BP) management after successful endovascular therapy improved 90-day functional outcomes compared with guideline-recommended care.
A multicenter randomized...
06/09/2026
Neurology
a strand of RNA
News
SKY-0515 Shows Sustained Biomarker Reductions in Huntington’s Disease
06/01/2026
Maria Mantas
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational oral RNA splicing modifier, reduced mutant huntingtin (mHTT) protein levels in blood by up to 69% and PMS1 mRNA by up to 26% in a phase 1/2 Huntington’s disease (HD) trial. 
SKY-0515, an investigational...
06/01/2026
Neurology
a man lays in bed unable to sleep
News
Accelerometer Sleep Metrics Linked to Dementia Risk in Older Adults
05/26/2026
Maria Mantas
Disruptions in sleep-wake cycles may provide scalable early markers for dementia risk in older adults, according to cohort study findings.
Disruptions in sleep-wake cycles may provide scalable early markers for dementia risk in older adults, according to cohort study findings.
Disruptions in sleep-wake cycles...
05/26/2026
Neurology
a side profile of a human head, with the top portion appearing to be made of shattered, crumpled paper
News
Plasma Biomarkers Predict Cognitive Decline in Early-Onset Dementia
05/11/2026
Maria Mantas
In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
In a South Korea–based multicenter cohort, plasma phosphorylated tau217 (p-tau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL) were associated with cognitive decline in early-onset Alzheimer disease (EOAD). 
In a South Korea–based...
05/11/2026
Neurology
A doctor interacts with an elderly patient
News
Cognitive Decline May Precede Cardiovascular Events in Older Adults
05/04/2026
Maria Mantas
Findings from a large Aspirin in Reducing Events in the Elderly (ASPREE) cohort suggest cognitive changes could serve as early indicators of cardiovascular risk. 
Findings from a large Aspirin in Reducing Events in the Elderly (ASPREE) cohort suggest cognitive changes could serve as early indicators of cardiovascular risk. 
Findings from a large Aspirin in...
05/04/2026
Neurology
a clinician reviews brain scans in front of a laptop
News
EVT Plus Medical Treatment Enhances Imaging Outcomes in Distal Stroke
04/24/2026
Maria Mantas
The addition of endovascular treatment (EVT) to best medical treatment (BMT) was associated with a higher likelihood of achieving good imaging outcomes compared with BMT alone in patients with a medium or distal vessel occlusion stroke.
The addition of endovascular treatment (EVT) to best medical treatment (BMT) was associated with a higher likelihood of achieving good imaging outcomes compared with BMT alone in patients with a medium or distal vessel occlusion stroke.
The addition of endovascular...
04/24/2026
Neurology
a man holds his head in his hands
News
Eptinezumab Improves Migraine-Related Cognitive Symptoms in INFUSE Study
04/20/2026
Maria Mantas
Real-world data presented at the American Academy of Neurology (AAN) 2026 Annual Meeting reported improvements in migraine-related cognitive symptoms with eptinezumab (VYEPTI).
Real-world data presented at the American Academy of Neurology (AAN) 2026 Annual Meeting reported improvements in migraine-related cognitive symptoms with eptinezumab (VYEPTI).
Real-world data presented at the...
04/20/2026
Neurology
a doctor sits at a desk and takes notes while looking at a laptop
News
Teleneurological Ward Rounds Noninferior to On-Site Care in Subacute Stroke Patients
04/13/2026
Maria Mantas
Teleneurological ward rounds were found noninferior to conventional on-site ward rounds in subacute inpatient stroke care, according to prospective study findings.
Teleneurological ward rounds were found noninferior to conventional on-site ward rounds in subacute inpatient stroke care, according to prospective study findings.
Teleneurological ward rounds...
04/13/2026
Neurology
an older man wearing a mask receives a vaccination shot in his upper arm
News
High-Dose Flu Vaccine Tied to Lower Alzheimer Risk
04/09/2026
Brionna Mendoza
High-dose influenza vaccination may confer additional neuroprotective benefit beyond standard-dose formulations, according to results from a new, large retrospective cohort study published in Neurology.
High-dose influenza vaccination may confer additional neuroprotective benefit beyond standard-dose formulations, according to results from a new, large retrospective cohort study published in Neurology.
High-dose influenza vaccination...
04/09/2026
Neurology

Alzheimer's Disease CME Series

Emerging Treatments for Early Alzheimer Disease: Efficacy and Safety Data
11/17/2020
Emerging Treatments for Early Alzheimer Disease: Efficacy and Safety Data To view accreditation information/faculty disclosures for the program, click 
Emerging Treatments for Early Alzheimer Disease: Efficacy and Safety Data To view accreditation information/faculty disclosures for the program, click 
Emerging Treatments for Early...
11/17/2020
Neurology

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