Donor Demographics and Laboratory Parameters as Predictors of Allogenic Peripheral Stem Cell Mobilization Outcome based on CD34+ cell count in a Tertiary Hospital in the Philippines
Efficient mobilization of hematopoietic stem cells (HSCs) is essential for successful allogeneic transplantation. CD34+ cell count serves as the primary marker of mobilization adequacy, yet limited data exist on donor-related predictors, particularly in Filipino populations. This study determined the influence of donor demographic and laboratory parameters on CD34+ cell mobilization outcomes among healthy adult donors.
Materials and Methods/Case Presentation/Objective:
This retrospective cohort study included 28 healthy adult donors who underwent peripheral blood stem cell (PBSC) collection at a tertiary hospital from 2015 to 2024. Donor demographics and pre- and post-G-CSF laboratory values were collected. Adequate mobilization was defined as a CD34+ cell yield of ≥2 ×10⁶ cells/kg. Generalized Linear Models (GLM) with Poisson distribution and robust standard errors were used to estimate crude and adjusted prevalence ratios (PRs) for adequate mobilization.
Results/Description/Main Outcome Measure(s):
Most donors were male (64.29%) with a mean age of 36.93 years and a mean BMI of 27.39 kg/m². Adequate mobilization was observed in 85.71% of donors. Donor height was significantly associated with CD34+ cell mobilization (Adjusted PR = 1.03; 95% CI: 1.00-1.06; p = 0.040). Other variables, including age, sex, BMI, hemoglobin, hematocrit, WBC, and platelet counts, showed no significant associations after adjustment.
Conclusion(s).:
Height was identified as a significant predictor of CD34+ cell mobilization. These findings support its inclusion in donor screening protocols. Larger studies with higher sample sizes are recommended to validate predictive factors and optimize mobilization strategies.
Trademarked Items:
References: [1] Hassan, M., Husin, A., Mustaffa, R., Hassan, R., Ibrahim, M., Abdullah, A., … & Noor, N. (2020). Risk factors for poor autologous peripheral blood stem cell mobilization among lymphoproliferative disease patients. Bangladesh Journal of Medical Science, 19(3), 458-466. https://doi.org/10.3329/bjms.v19i3.45863
[2] Lussier, M. and Gallicchio, V. (2017). Therapeutic effects of aging stem cells. Stem Cell & Regenerative Medicine, 1(3), 1-9. https://doi.org/10.33425/2639-9512.1022
[3] Martino, M., Gori, M., Moscato, T., Naso, V., Ferreri, A., Provenzano, F., … & Pitino, A. (2019). Challenge to predict mobilized peripheral blood stem cells on the fourth day of granulocyte colony-stimulating factor treatment in healthy donors: predictive value of basal cd34+ cell and platelet counts. Biology of Blood and Marrow Transplantation, 25(8), 1586-1591. https://doi.org/10.1016/j.bbmt.2019.04.011
