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NEO100-01 Meets Primary End Point, Supporting Further Development in IDH1-Mutant Glioma
08/31/2026
Emily Estrada
Topline results from the phase 2a NEO100-01 trial showed that intranasal NEO100 achieved a 48.9% 6-month progression-free survival rate in patients with recurrent IDH1-mutant high-grade glioma, significantly exceeding the prespecified 20%...
Topline results from the phase 2a NEO100-01 trial showed that intranasal NEO100 achieved a 48.9% 6-month progression-free survival rate in patients with recurrent IDH1-mutant high-grade glioma, significantly exceeding the prespecified 20%...
Topline results from the phase...
08/31/2026
Oncology
News
Zanidatamab Plus Chemotherapy Improves Overall Survival in HER2-Positive Advanced Gastroesophageal Adenocarcinoma
08/31/2026
Stephanie Holland
Updated phase 3 HERIZON-GEA-01 results showed that zanidatamab-based regimens improved overall survival compared with trastuzumab plus chemotherapy in first-line HER2-positive advanced gastroesophageal adenocarcinoma, strengthening the...
Updated phase 3 HERIZON-GEA-01 results showed that zanidatamab-based regimens improved overall survival compared with trastuzumab plus chemotherapy in first-line HER2-positive advanced gastroesophageal adenocarcinoma, strengthening the...
Updated phase 3 HERIZON-GEA-01...
08/31/2026
Oncology
News
Real-World Study Shows Nirogacestat Provides Sustained Disease Control and Symptom Improvement in Patients With Desmoid Tumors
08/31/2026
Emily Estrada
A real-world study of nirogacestat in patients with desmoid tumors demonstrated durable disease control, tumor responses, and meaningful pain improvement, with many patients also reducing or discontinuing analgesics, reinforcing the clinical...
A real-world study of nirogacestat in patients with desmoid tumors demonstrated durable disease control, tumor responses, and meaningful pain improvement, with many patients also reducing or discontinuing analgesics, reinforcing the clinical...
A real-world study of...
08/31/2026
Oncology
FDA Approval
FDA Approves First-in-Class Rusfertide to Reduce Phlebotomy Burden in Adult Patients With Polycythemia Vera
08/31/2026
Emily Estrada
The FDA has approved rusfertide for the treatment of erythrocytosis in adult patients with polycythemia vera after results from the phase 3 VERIFY trial showed showed improved hematocrit control, reduced phlebotomy requirements, and improved...
The FDA has approved rusfertide for the treatment of erythrocytosis in adult patients with polycythemia vera after results from the phase 3 VERIFY trial showed showed improved hematocrit control, reduced phlebotomy requirements, and improved...
The FDA has approved rusfertide...
08/31/2026
Oncology
FDA Approval
FDA Approves Ropeginterferon Alfa-2b for Adult Patients With Essential Thrombocythemia
08/31/2026
Emily Estrada
Based on results from the SURPASS ET trial, the FDA has approved ropeginterferon alfa-2b for adult patients with essential thrombocythemia regardless of genotype or disease status, marking the first new FDA-approved treatment for the disease...
Based on results from the SURPASS ET trial, the FDA has approved ropeginterferon alfa-2b for adult patients with essential thrombocythemia regardless of genotype or disease status, marking the first new FDA-approved treatment for the disease...
Based on results from the...
08/31/2026
Oncology
News
Response-Guided PD-1 Therapy May Support Treatment De-Escalation in Advanced Cutaneous Squamous Cell Carcinoma
08/28/2026
Emily Estrada
A retrospective cohort study found that limited PD-1 exposure frequently produced durable disease control in patients with locally advanced or resectable cutaneous squamous cell carcinoma, with uncertain incremental benefit from treatment...
A retrospective cohort study found that limited PD-1 exposure frequently produced durable disease control in patients with locally advanced or resectable cutaneous squamous cell carcinoma, with uncertain incremental benefit from treatment...
A retrospective cohort study...
08/28/2026
Oncology
News
Ivonescimab Plus Chemotherapy Extends PFS After Tyrosine Kinase Inhibitor Progression in EGFR-Mutant Non-Small Cell Lung Cancer
08/28/2026
Stephanie Holland
Results from the phase 3 HARMONi trial showed that ivonescimab plus pemetrexed and carboplatin significantly improved progression-free survival compared with chemotherapy alone in patients with advanced EGFR-mutant non-small cell lung cancer...
Results from the phase 3 HARMONi trial showed that ivonescimab plus pemetrexed and carboplatin significantly improved progression-free survival compared with chemotherapy alone in patients with advanced EGFR-mutant non-small cell lung cancer...
Results from the phase 3 HARMONi...
08/28/2026
Oncology
News
Expert Consensus Establishes Imaging Recommendations for High-Risk Cutaneous Squamous Cell Carcinoma
08/28/2026
Emily Estrada
A multidisciplinary Delphi consensus established staging and surveillance imaging recommendations for localized cutaneous squamous cell carcinoma, supporting imaging for tumors with at least a 15% risk of metastasis and identifying specific...
A multidisciplinary Delphi consensus established staging and surveillance imaging recommendations for localized cutaneous squamous cell carcinoma, supporting imaging for tumors with at least a 15% risk of metastasis and identifying specific...
A multidisciplinary Delphi...
08/28/2026
Oncology
News
Twice-Daily Radiation Associated With Better Patient-Reported Outcomes in Limited-Stage Small Cell Lung Cancer
08/27/2026
Emily Estrada
A planned patient-reported outcomes analysis from NRG-LU005 found that adding atezolizumab to chemoradiation did not significantly reduce clinically meaningful decline at 15 months, while twice-daily radiation was consistently associated with...
A planned patient-reported outcomes analysis from NRG-LU005 found that adding atezolizumab to chemoradiation did not significantly reduce clinically meaningful decline at 15 months, while twice-daily radiation was consistently associated with...
A planned patient-reported...
08/27/2026
Oncology
News
Tarlatamab Reduces Symptom Burden and Treatment Side Effects in Extensive-Stage Small Cell Lung Cancer
08/27/2026
Emily Estrada
Patient-reported outcomes from the phase 3 DeLLphi-304 trial showed that tarlatamab delayed deterioration in key cancer-related symptoms and physical functioning while reducing treatment-related side-effect burden compared with standard...
Patient-reported outcomes from the phase 3 DeLLphi-304 trial showed that tarlatamab delayed deterioration in key cancer-related symptoms and physical functioning while reducing treatment-related side-effect burden compared with standard...
Patient-reported outcomes from...
08/27/2026
Oncology

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