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Chronic Wound Infection Topic Center

Systematic Review
08/18/2025
Manuela de Mendonça Figueirêdo Coelho, PhD; Beatriz Moreira Alves Avelino, RN; Beatriz Alvez de Oliveira, MSN; Mariana Araújo Rios, RN; Fabiane do Amaral Gubert, PhD; Mariana Cavalcante Martins, PhD; Janaína Fonseca Victor Coutinho, PhD; Paula Sacha Frota Nogueira, PhD; Rachel Gabriel Bastos Barbosa, PhD; Viviane Mamede Vasconcelos Cavalcante, PhD
The authors of this article conducted a systematic review to determine how prevalent biofilm is in chronic wounds.
The authors of this article conducted a systematic review to determine how prevalent biofilm is in chronic wounds.
The authors of this article...
08/18/2025
Wounds
Case Report
08/04/2025
Stephanie Behme, DPM; Shiwei Zhou, MD; Andrew Brown, DPM; Gary M. Rothenberg, DPM
A 64-year-old female presented with an enlarging ulceration that failed to respond to antibiotic therapy based on routine aerobic culture results. Acid-fast bacilli (AFB) cultures revealed a nontuberculous mycobacteria infection with...
A 64-year-old female presented with an enlarging ulceration that failed to respond to antibiotic therapy based on routine aerobic culture results. Acid-fast bacilli (AFB) cultures revealed a nontuberculous mycobacteria infection with...
A 64-year-old female presented...
08/04/2025
Wounds
mina izadjoo phd
Videos
06/26/2023
Mina Izadjoo
In this video, Dr. Izadjoo presents research that is focused on novel and cost-effective antimicrobials, including antifungals, ranging from small molecules to recombinant proteins.
In this video, Dr. Izadjoo presents research that is focused on novel and cost-effective antimicrobials, including antifungals, ranging from small molecules to recombinant proteins.
In this video, Dr. Izadjoo...
06/26/2023
Wounds
Case Report
05/16/2023
Rong Wang; Zhen Zhao; Haiyan Wang; Shuang Liang; Lifeng Qin; Hairui Gao; Gang Zhao; Ying Li
Two patients with recalcitrant perineal wounds saw full wound closure within 2 weeks following treatment with platelet-rich plasma.
Two patients with recalcitrant perineal wounds saw full wound closure within 2 weeks following treatment with platelet-rich plasma.
Two patients with recalcitrant...
05/16/2023
Wounds
Consensus Statements
05/15/2023
Paul J. Kim, DPM, MS, FACFAS; Luis G. Fernández; Marc R. Matthews, MD, FACS, MS
The authors present their consensus opinion on the use of a synthetic hybrid-scale fiber matrix for the management of open wounds.
The authors present their consensus opinion on the use of a synthetic hybrid-scale fiber matrix for the management of open wounds.
The authors present their...
05/15/2023
Wounds
Case Report
05/08/2023
Marek K. Dobke
A 29-year-old male who was undergoing chemotherapy for sarcoma presented with a nonhealing leg wound; 22 weeks after initiating treatment with a structural microvascular tissue allograft, the wound was fully closed.
A 29-year-old male who was undergoing chemotherapy for sarcoma presented with a nonhealing leg wound; 22 weeks after initiating treatment with a structural microvascular tissue allograft, the wound was fully closed.
A 29-year-old male who was...
05/08/2023
Wounds
Case Report
04/28/2023
Huang Xuecheng; Yang Junxing; Chen Haoxiong; Guo Fuming; Xu Qiliang
The authors detail a case in which elastic therapeutic tape was successfully used to close a surgical wound that had failed to heal almost 3 months after surgery.
The authors detail a case in which elastic therapeutic tape was successfully used to close a surgical wound that had failed to heal almost 3 months after surgery.
The authors detail a case in...
04/28/2023
Wounds
Review
04/19/2023
Daniel Zhang; Gabrielle McMullin; Adriel Song Wei Leong
The authors conducted a review focused on the physiological impact of blue light on wound healing.
The authors conducted a review focused on the physiological impact of blue light on wound healing.
The authors conducted a review...
04/19/2023
Wounds
Case Report
03/22/2023
Marco Romanelli; Cristian Fidanzi; Giammarco Granieri; Matteo Bevilacqua; Flavia Manzo Margiotta; Valentina Dini; Alessandra Michelucci; Giorgia Salvia
In this case report, the authors discuss a 50-year-old female who presented with necrotic, punched-out ulcers on her back.
In this case report, the authors discuss a 50-year-old female who presented with necrotic, punched-out ulcers on her back.
In this case report, the authors...
03/22/2023
Wounds
Case Report
03/07/2023
James McKee; Arnold Paul C. Cua; Nicholas Chang; Valerie L. Marmolejo (Schade), DPM, MS, CTBS, MWC, FACFAS, FACFAOM
The authors of this case report present a 78-year-old male with primary cutaneous mucormycosis who was treated with surgical debridement and antibiotics.
The authors of this case report present a 78-year-old male with primary cutaneous mucormycosis who was treated with surgical debridement and antibiotics.
The authors of this case report...
03/07/2023
Wounds

Multimedia

mina izadjoo phd
Videos
06/26/2023
Mina Izadjoo
In this video, Dr. Izadjoo presents research that is focused on novel and cost-effective antimicrobials, including antifungals, ranging from small molecules to recombinant proteins.
In this video, Dr. Izadjoo presents research that is focused on novel and cost-effective antimicrobials, including antifungals, ranging from small molecules to recombinant proteins.
In this video, Dr. Izadjoo...
06/26/2023
Wounds
Preview Image
Videos
10/03/2022
This video features an interview with members of the ECRI Institute-Penn Medicine Evidence-Based Practice Center (ECRI) and the Agency for Healthcare Research and Quality regarding a systematic review of skin substitutes conducted by the ECRI...
This video features an interview with members of the ECRI Institute-Penn Medicine Evidence-Based Practice Center (ECRI) and the Agency for Healthcare Research and Quality regarding a systematic review of skin substitutes conducted by the ECRI...
This video features an interview...
10/03/2022
Wounds
WCLN logo
SAWC Insights
05/27/2022
Robert J. Klein, DPM, FACFAS, CWS
In this video, Robert Klein, DPM, FACFAS, CWS, discusses why it's difficult to differentiate between malignant transformations of a chronic wound and the primary malignancy within the ulceration.
In this video, Robert Klein, DPM, FACFAS, CWS, discusses why it's difficult to differentiate between malignant transformations of a chronic wound and the primary malignancy within the ulceration.
In this video, Robert Klein,...
05/27/2022
Wounds
Preview Image
Videos
01/15/2022
Matthew J. Regulski, DPM, ABMSP, CMET, FAPWH(c)
This video showcases the mechanisms of action and use of a topical gel in the scope of chronic, hard-to-treat wounds.
This video showcases the mechanisms of action and use of a topical gel in the scope of chronic, hard-to-treat wounds.
This video showcases the...
01/15/2022
Wounds
Preview Image
Expert Insights
12/01/2021
Kazem Kazempour
In this video, Kazem Kazempour , PhD, explains why it is so difficult for new wound healing therapies for DFUs to be approved by the FDA.
In this video, Kazem Kazempour , PhD, explains why it is so difficult for new wound healing therapies for DFUs to be approved by the FDA.
In this video, Kazem Kazempour ,...
12/01/2021
Wounds
Podcasts
08/23/2021
Listen to "The Use of an Advanced Fluorescence Imaging System to Target Wound Healing" on Spreaker.
Listen to "The Use of an Advanced Fluorescence Imaging System to Target Wound Healing" on Spreaker.
Listen to "The Use of an...
08/23/2021
Wounds
Podcasts
05/20/2021
In day-to-day clinical practice, a wound care clinician will find themselves continually educating patients and other clinicians on the basic fundamentals of wound care.
In day-to-day clinical practice, a wound care clinician will find themselves continually educating patients and other clinicians on the basic fundamentals of wound care.
In day-to-day clinical practice,...
05/20/2021
Wounds
Podcasts
04/27/2021
In this podcast, Laura Swoboda DNP, APNP, FNP-BC, CWOCN-AP, explores methods of pain control that are utilized by wound centers, which consist of pharmacologic and non-pharmacologic interventions.
In this podcast, Laura Swoboda DNP, APNP, FNP-BC, CWOCN-AP, explores methods of pain control that are utilized by wound centers, which consist of pharmacologic and non-pharmacologic interventions.
In this podcast, Laura Swoboda...
04/27/2021
Wounds
Podcasts
02/10/2021
In this podcast, Janice M. Beitz, PhD, RN, CS, CNOR, CWOCN-AP, CRNP, APNC, ANEF, FNAP, FAAN, and Martha Kelso, RN, LNC, HBOT, discuss wound care with a focus on pharmacology. They delve into how different medications affect wounds and their...
In this podcast, Janice M. Beitz, PhD, RN, CS, CNOR, CWOCN-AP, CRNP, APNC, ANEF, FNAP, FAAN, and Martha Kelso, RN, LNC, HBOT, discuss wound care with a focus on pharmacology. They delve into how different medications affect wounds and their...
In this podcast, Janice M....
02/10/2021
Wounds
Podcasts
12/17/2020
Listen to "The Importance of Wound Measurements and How it Affects Treatment Plans" on Spreaker.
Listen to "The Importance of Wound Measurements and How it Affects Treatment Plans" on Spreaker.
Listen to "The Importance of...
12/17/2020
Wounds
Analysis
03/26/2026
Scott Nelson
This speaker discusses the audit implications of inaccuracies in wound care documentation, highlighting the importance of maintaining documentation integrity at practices of any size.
This speaker discusses the audit implications of inaccuracies in wound care documentation, highlighting the importance of maintaining documentation integrity at practices of any size.
This speaker discusses the audit...
03/26/2026
Wounds
Analysis
03/23/2026
Scott Nelson
This author emphasizes that inconsistencies in measurement of wounds for CTPs can lead to red flags for auditors, as erratic size changes or consistent overestimations may suggest improper billing practices.
This author emphasizes that inconsistencies in measurement of wounds for CTPs can lead to red flags for auditors, as erratic size changes or consistent overestimations may suggest improper billing practices.
This author emphasizes that...
03/23/2026
Wounds
Analysis
03/19/2026
Scott Nelson
In the first of three videos, this speaker focuses on the critical role of measurement accuracy in wound care, emphasizing its impact on medical necessity and reimbursement processes.
In the first of three videos, this speaker focuses on the critical role of measurement accuracy in wound care, emphasizing its impact on medical necessity and reimbursement processes.
In the first of three videos,...
03/19/2026
Wounds
Analysis
03/17/2026
Kathleen D. Schaum, MS
Now that Medicare is no longer paying for CTP wastage, Kathleen D. Schaum discusses how to adjust your processes to accommodate that change.
Now that Medicare is no longer paying for CTP wastage, Kathleen D. Schaum discusses how to adjust your processes to accommodate that change.
Now that Medicare is no longer...
03/17/2026
Wounds
Analysis
03/13/2026
Kathleen D. Schaum, MS
In the second part of this video series, Kathleen Schaum explores exceptions to the Medicare CTP payment of $127.14 per square centimeter.
In the second part of this video series, Kathleen Schaum explores exceptions to the Medicare CTP payment of $127.14 per square centimeter.
In the second part of this video...
03/13/2026
Wounds
Analysis
03/11/2026
Kathleen D. Schaum, MS
In part 1 of a video series, Kathleen D. Schaum breaks down how to implement using the same allowable payment rate for all brands of CTP sheets.
In part 1 of a video series, Kathleen D. Schaum breaks down how to implement using the same allowable payment rate for all brands of CTP sheets.
In part 1 of a video series,...
03/11/2026
Wounds
Viewpoints
03/03/2026
David Alper, DPM
In this interview, the speaker outlines concerns about regulatory overcorrection, escalating product costs, and the growing influence of vendor-driven revenue messaging in physician offices.
In this interview, the speaker outlines concerns about regulatory overcorrection, escalating product costs, and the growing influence of vendor-driven revenue messaging in physician offices.
In this interview, the speaker...
03/03/2026
Wounds
Viewpoints
02/24/2026
David Alper, DPM
As multi-billion dollar spending on CTPs draws heightened regulatory scrutiny, policymakers are stepping in—fast and forcefully. But as new rules roll out, many clinicians worry that cost containment efforts could unintentionally undermine...
As multi-billion dollar spending on CTPs draws heightened regulatory scrutiny, policymakers are stepping in—fast and forcefully. But as new rules roll out, many clinicians worry that cost containment efforts could unintentionally undermine...
As multi-billion dollar spending...
02/24/2026
Wounds
Viewpoints
02/16/2026
Frank Aviles, Jr., PT, CWS, FACCWS, CLT-LANA, ALM, AWCC
Advanced wound imaging technologies—including near-infrared spectroscopy, thermography, and fluorescence imaging—are transforming how clinicians select and time cellular tissue product (CTP) applications.
Advanced wound imaging technologies—including near-infrared spectroscopy, thermography, and fluorescence imaging—are transforming how clinicians select and time cellular tissue product (CTP) applications.
Advanced wound imaging...
02/16/2026
Wounds
Viewpoints
02/10/2026
Jim McDannald, DPM
In this part of a recent interview with Jim McDannald, DPM, of Podiatry Growth, he shares how he sees practices adapting in light of regulatory changes, and what he predicts for those that do not find a way to do so.
In this part of a recent interview with Jim McDannald, DPM, of Podiatry Growth, he shares how he sees practices adapting in light of regulatory changes, and what he predicts for those that do not find a way to do so.
In this part of a recent...
02/10/2026
Wounds

From the Publications

Case Report
08/04/2025
Stephanie Behme, DPM; Shiwei Zhou, MD; Andrew Brown, DPM; Gary M. Rothenberg, DPM
A 64-year-old female presented with an enlarging ulceration that failed to respond to antibiotic therapy based on routine aerobic culture results. Acid-fast bacilli (AFB) cultures revealed a nontuberculous mycobacteria infection with...
A 64-year-old female presented with an enlarging ulceration that failed to respond to antibiotic therapy based on routine aerobic culture results. Acid-fast bacilli (AFB) cultures revealed a nontuberculous mycobacteria infection with...
A 64-year-old female presented...
08/04/2025
Wounds
Case Report
05/16/2023
Rong Wang; Zhen Zhao; Haiyan Wang; Shuang Liang; Lifeng Qin; Hairui Gao; Gang Zhao; Ying Li
Two patients with recalcitrant perineal wounds saw full wound closure within 2 weeks following treatment with platelet-rich plasma.
Two patients with recalcitrant perineal wounds saw full wound closure within 2 weeks following treatment with platelet-rich plasma.
Two patients with recalcitrant...
05/16/2023
Wounds
Case Report
05/08/2023
Marek K. Dobke
A 29-year-old male who was undergoing chemotherapy for sarcoma presented with a nonhealing leg wound; 22 weeks after initiating treatment with a structural microvascular tissue allograft, the wound was fully closed.
A 29-year-old male who was undergoing chemotherapy for sarcoma presented with a nonhealing leg wound; 22 weeks after initiating treatment with a structural microvascular tissue allograft, the wound was fully closed.
A 29-year-old male who was...
05/08/2023
Wounds
Case Report
04/28/2023
Huang Xuecheng; Yang Junxing; Chen Haoxiong; Guo Fuming; Xu Qiliang
The authors detail a case in which elastic therapeutic tape was successfully used to close a surgical wound that had failed to heal almost 3 months after surgery.
The authors detail a case in which elastic therapeutic tape was successfully used to close a surgical wound that had failed to heal almost 3 months after surgery.
The authors detail a case in...
04/28/2023
Wounds
Case Report
03/22/2023
Marco Romanelli; Cristian Fidanzi; Giammarco Granieri; Matteo Bevilacqua; Flavia Manzo Margiotta; Valentina Dini; Alessandra Michelucci; Giorgia Salvia
In this case report, the authors discuss a 50-year-old female who presented with necrotic, punched-out ulcers on her back.
In this case report, the authors discuss a 50-year-old female who presented with necrotic, punched-out ulcers on her back.
In this case report, the authors...
03/22/2023
Wounds
Case Report
03/07/2023
James McKee; Arnold Paul C. Cua; Nicholas Chang; Valerie L. Marmolejo (Schade), DPM, MS, CTBS, MWC, FACFAS, FACFAOM
The authors of this case report present a 78-year-old male with primary cutaneous mucormycosis who was treated with surgical debridement and antibiotics.
The authors of this case report present a 78-year-old male with primary cutaneous mucormycosis who was treated with surgical debridement and antibiotics.
The authors of this case report...
03/07/2023
Wounds
Case Series
02/01/2023
Chayane K.L. de Carvalho; Mauren Abreu de Souza; Michel M. Dalmedico; Beatriz Luci Fernandes, PhD
This series examines 3 cases in which an autologous biopolymer fibrin membrane was used to treat chronic oncological wounds that had displayed no sign of healing after more than 6 months of conventional treatment.
This series examines 3 cases in which an autologous biopolymer fibrin membrane was used to treat chronic oncological wounds that had displayed no sign of healing after more than 6 months of conventional treatment.
This series examines 3 cases in...
02/01/2023
Wounds
Case Series
01/31/2023
Yi Arnold; Jeremy Perse; Deepali Darji, DPM
The authors report on 3 cases of chronic pretibial ulcers successfully treated with fenestration and the application of an antimicrobial fetal bovine acellular dermal matrix.
The authors report on 3 cases of chronic pretibial ulcers successfully treated with fenestration and the application of an antimicrobial fetal bovine acellular dermal matrix.
The authors report on 3 cases of...
01/31/2023
Wounds
Case Series
01/31/2023
Leydi Castro; Nelly Esperanza Jaimes; Luis Fernando Orduz; Diana Isabel Cáceres; Maria Andreina Pulido
01/31/2023
Wounds
Original Research
04/16/2026
Rene Amaya, MD; Emily Heisler, MSN, RN, FNP-C
This retrospective series evaluate cutaneous safety and tolerability associated with use of a pure hypochlorous acid-preserved cleanser in preterm and neonatal patients with complex wounds
This retrospective series evaluate cutaneous safety and tolerability associated with use of a pure hypochlorous acid-preserved cleanser in preterm and neonatal patients with complex wounds
This retrospective series...
04/16/2026
Wounds
Case Series
04/08/2026
Thea Price, MD; Katie Meador, NP
In a retrospective series, synthetic electrospun fiber matrix promoted healing of complex tunneling and undermining wounds, helping avoid flap reconstruction or amputation in high-risk patients.
In a retrospective series, synthetic electrospun fiber matrix promoted healing of complex tunneling and undermining wounds, helping avoid flap reconstruction or amputation in high-risk patients.
In a retrospective series,...
04/08/2026
Wounds
Case Series
03/27/2026
Suzie Ehmann, PhD, DPT, CWS, CLWT, CLT-LANA; Sandi Davis, PT, DPT, CLT-LANA, CLWT
This case series shows that a dual-layer compression system can effectively reduce limb volume, support wound healing, and improve patient independence in complex lymphedema.
This case series shows that a dual-layer compression system can effectively reduce limb volume, support wound healing, and improve patient independence in complex lymphedema.
This case series shows that a...
03/27/2026
Wounds
Case Series
03/10/2026
Sibat Noor, MD; Soniya Singh, BS; Katherine Cordero Bermudez, MD; Scott A. Gorenstein, MD
Eight refractory pyoderma gangrenosum cases healed with immunosuppression, selective debridement, and bilayer skin substitute, supporting surgery under controlled inflammation.
Eight refractory pyoderma gangrenosum cases healed with immunosuppression, selective debridement, and bilayer skin substitute, supporting surgery under controlled inflammation.
Eight refractory pyoderma...
03/10/2026
Wounds
Original Research
02/26/2026
Abigail Royfman, BS; Sarah Lux, BA; Kennedy Couch, BS; Molynna Nguyen, BS; Mandy Wong, BS; Emily Gong, BS; Richard Simman, MD
CAMPs may reduce long-term lower-limb amputation risk and improve amputation-free survival in diabetic foot ulcer care.
CAMPs may reduce long-term lower-limb amputation risk and improve amputation-free survival in diabetic foot ulcer care.
CAMPs may reduce long-term...
02/26/2026
Wounds
Case Report
02/24/2026
Hydrosurgical debridement combined with negative pressure therapy effectively treated extensive chronic wounds from polyacrylamide hydrogel breast injections, resulting in successful healing without recurrence at 12–18 months.
Hydrosurgical debridement combined with negative pressure therapy effectively treated extensive chronic wounds from polyacrylamide hydrogel breast injections, resulting in successful healing without recurrence at 12–18 months.
Hydrosurgical debridement...
02/24/2026
Wounds
Case Report
02/11/2026
Chi Young Bang, MD, PhD; Seung Ho Lee, MD; Kun Yong Sung, PhD, MD
Systemic lupus erythematosus may present with refractory leg ulcers unresponsive to immunosuppression, prompting consideration of multimodal anticoagulation and advanced wound therapies.
Systemic lupus erythematosus may present with refractory leg ulcers unresponsive to immunosuppression, prompting consideration of multimodal anticoagulation and advanced wound therapies.
Systemic lupus erythematosus may...
02/11/2026
Wounds
Case Report
02/06/2026
Mohamad Kharashgah, MBBS; Qusai Swedan, MD; Saleh Abualhaj, MD
This case report explores management considerations for full-thickness burns with exposed Achilles tendon in an immunocompromised patient.
This case report explores management considerations for full-thickness burns with exposed Achilles tendon in an immunocompromised patient.
This case report explores...
02/06/2026
Wounds
Case Report
01/28/2026
Francisco Javier Ramírez-Fernández, MD; Isidro Velázquez-Jacobo, MD; Adriana Lozano-Platonoff, MD; Monica Navarrete-Martínez, MD; José Contreras-Ruiz, MD
This case report discusses region-specific reconstruction of complex foot trauma using plantar-to-plantar punch grafting to provide durable, glabrous coverage.
This case report discusses region-specific reconstruction of complex foot trauma using plantar-to-plantar punch grafting to provide durable, glabrous coverage.
This case report discusses...
01/28/2026
Wounds

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