Conference Coverage

First-Line Encorafenib Plus Binimetinib and Nivolumab for Patients With BRAF-Mutated Melanoma Brain Metastases

07/24/2025

Zeynep Eroglu, MD, Moffitt Cancer Center, Tampa, Florida, discusses results from the SWOG S2000 study which compared first-line encorafenib plus binimetinib and nivolumab to ipilimumab plus nivolumab among patients with BRAFV600-mutated melanoma brain metastases.

Study results demonstrated that encorafenib plus binimetinib and nivolumab significantly improved progression-free survival in this patient population.

These data were presented at the American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, Illinois.

Source:

Eroglu Z, Moon J, Najjar Y, et al. A randomized phase 2 trial of encorafenib + binimetinib + nivolumab vs ipilimumab + nivolumab in BRAFV600-mutant melanoma brain metastases: SWOG S2000 (NCT04511013). Presented at 2025 ASCO Annual Meeting. May 30-June 3, 2025; Chicago, IL. Abstract LBA9507

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