Based on results from the phase 3 MANEUVER trial, the FDA accepted the New Drug Application for pimicotinib for the treatment of patients with tenosynovial giant cell tumor.
Based on results from the phase 3 MANEUVER trial, the FDA accepted the New Drug Application for pimicotinib for the treatment of patients with tenosynovial giant cell tumor.
Systemic CSF-1R inhibition provides an effective option for unresectable or recurrent tenosynovial giant cell tumor, with safety and tolerability favoring newer agents and potentially shifting first-line treatment paradigms.
Systemic CSF-1R inhibition provides an effective option for unresectable or recurrent tenosynovial giant cell tumor, with safety and tolerability favoring newer agents and potentially shifting first-line treatment paradigms.
Key Clinical Takeaways:
Design/Population: This retrospective study evaluated plasma ctDNA in 42 patients with muscle-invasive bladder cancer treated with trimodality therapy. Patients were stratified by post-treatment ctDNA...
Key Clinical Takeaways:
Design/Population: This retrospective study evaluated plasma ctDNA in 42 patients with muscle-invasive bladder cancer treated with trimodality therapy. Patients were stratified by post-treatment ctDNA...
Stereotactic ablative radiotherapy provides durable local control and delays systemic therapy escalation in selected patients with oligoprogressive metastatic renal cell carcinoma receiving systemic therapy.
Stereotactic ablative radiotherapy provides durable local control and delays systemic therapy escalation in selected patients with oligoprogressive metastatic renal cell carcinoma receiving systemic therapy.
Based on results from the phase 3 MANEUVER trial, the FDA accepted the New Drug Application for pimicotinib for the treatment of patients with tenosynovial giant cell tumor.
Based on results from the phase 3 MANEUVER trial, the FDA accepted the New Drug Application for pimicotinib for the treatment of patients with tenosynovial giant cell tumor.
Elevated baseline and early on-treatment serum levels of LDH and α-HBDH following first-line chemoimmunotherapy were independently associated with survival outcomes in extensive-stage small cell lung cancer.
Elevated baseline and early on-treatment serum levels of LDH and α-HBDH following first-line chemoimmunotherapy were independently associated with survival outcomes in extensive-stage small cell lung cancer.
Results from the STELLAR-303 trial demonstrate that zanzalintinib plus atezolizumab significantly improves overall survival compared with regorafenib in relapsed or refractory metastatic colorectal cancer without MSI-H or dMMR tumors.
Results from the STELLAR-303 trial demonstrate that zanzalintinib plus atezolizumab significantly improves overall survival compared with regorafenib in relapsed or refractory metastatic colorectal cancer without MSI-H or dMMR tumors.
Results from a real-world imaging analysis suggest that ¹⁸F-DOPA-PET and advanced MRI sequences may provide earlier indicators of treatment response than conventional MRI in patients with IDH-mutant glioma receiving IDH inhibitors.
Results from a real-world imaging analysis suggest that ¹⁸F-DOPA-PET and advanced MRI sequences may provide earlier indicators of treatment response than conventional MRI in patients with IDH-mutant glioma receiving IDH inhibitors.
Results from a retrospective analysis indicate that a multi-omics model integrating clinical, radiomic, and dosiomic features accurately predicts response to whole-brain radiotherapy in patients with small cell lung cancer brain metastases.
Results from a retrospective analysis indicate that a multi-omics model integrating clinical, radiomic, and dosiomic features accurately predicts response to whole-brain radiotherapy in patients with small cell lung cancer brain metastases.
Results from a phase 2 trial show that tinengotinib demonstrates strong antitumor activity in
patients with advanced cholangiocarcinoma who developed resistance to prior FGFR inhibitor therapy.
Results from a phase 2 trial show that tinengotinib demonstrates strong antitumor activity in
patients with advanced cholangiocarcinoma who developed resistance to prior FGFR inhibitor therapy.
Results from the phase 2 CART19-BE-02 trial demonstrate that varnimcabtagene autoleucel produces high rates of complete remission with undetectable MRD in relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
Results from the phase 2 CART19-BE-02 trial demonstrate that varnimcabtagene autoleucel produces high rates of complete remission with undetectable MRD in relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
Secondary analysis results from the phase 3 TROG 05.01 trial identified that patients with cutaneous squamous cell carcinoma of the head and neck who display higher risk features experience significantly worse DFS following postoperative...
Secondary analysis results from the phase 3 TROG 05.01 trial identified that patients with cutaneous squamous cell carcinoma of the head and neck who display higher risk features experience significantly worse DFS following postoperative...