News

FDA Approval

FDA Approves Zenocutuzumab for Patients With NRG1 Fusion-Positive Advanced Cholangiocarcinoma

05/08/2026

Stephanie Holland

Based on results from the phase 2 eNRGy trial, the FDA has approved zenocutuzumab for previously treated patients with advanced cholangiocarcinoma harboring NRG1 gene fusions.

Based on results from the phase...

05/08/2026

Oncology

News

Neoadjuvant GOLP Demonstrates Efficacy, Safety in High-Risk Intrahepatic Cholangiocarcinoma

04/06/2026

Stephanie Holland

Results from a phase 2/3 trial demonstrate that neoadjuvant gemcitabine, oxaliplatin, lenvatinib, and toripalimab significantly improves survival compared with surgery alone in high-risk resectable intrahepatic cholangiocarcinoma.

Results from a phase 2/3 trial...

04/06/2026

Oncology

News

Tinengotinib Demonstrates Strong Antitumor Activity in FGFR-Altered Cholangiocarcinoma

02/04/2026

Stephanie Holland

Results from a phase 2 trial show that tinengotinib demonstrates strong antitumor activity in patients with advanced cholangiocarcinoma who developed resistance to prior FGFR inhibitor therapy.

Results from a phase 2 trial...

02/04/2026

Oncology

News

Lirafugratinib Demonstrates Efficacy, Safety for Previously Treated Patients With FGFR2 Fusion-Positive Cholangiocarcinoma

01/13/2026

Stephanie Holland

Results from the phase 1/2 ReFocus study show that lirafugratinib demonstrates promising efficacy and safety among FGFR inhibitor-naive patients with advanced or metastatic cholangiocarcinoma harboring FGFR2 fusions or rearrangements.

Results from the phase 1/2...

01/13/2026

Oncology

News

Lirafugratinib Demonstrates Efficacy, Safety for Previously Treated Patients With FGFR2 Fusion-Positive Cholangiocarcinoma

01/13/2026

Stephanie Holland

Results from the phase 1/2...

01/13/2026

Oncology

Conference Coverage

Addition of Stereotactic Body Radiotherapy to Chemotherapy for Patients With Inoperable, Locally Advanced Cholangiocarcinoma

05/28/2024

Allison Casey

According to a phase 2 trial presented at the 2024 ASCO Annual Meeting, adding stereotactic body radiotherapy to chemotherapy did not prolong progression-free survival for patients with advanced cholangiocarcinoma, however more mature data is...

According to a phase 2 trial...

05/28/2024

Oncology

News

Laparoscopic Hemihepatectomy vs Open Hemihepatectomy Among Patients With Primary or Metastatic Liver Tumors

05/17/2024

Results from the ORANGE II PLUS trial demonstrated that a minimally invasive, laparoscopic approach to hemihepatectomy shortened time to functional recovery compared to open, major hemihepatectomy among patients with primary or metastatic...

Results from the ORANGE II PLUS...

05/17/2024

Oncology

Conference Coverage

Tinegotinib Monotherapy Shows Efficacy Among Patients With Advanced/Metastatic Cholangiocarcinoma

01/20/2024

Stephanie Holland

Results from a phase 2 study found tinegotinib monotherapy demonstrated promising clinical efficacy and tolerable safety among patients with advanced/metastatic cholangiocarcinoma previously treated with an FGFR inhibitor and patients with...

Results from a phase 2 study...

01/20/2024

Oncology

Conference Coverage

Hepatic Arterial Infusion Pump Chemotherapy Improves Survival Outcomes for Intrahepatic Cholangiocarcinoma

01/19/2024

Allison Casey

According to results from a phase 2 trial, combining hepatic arterial infusion pump chemotherapy with systemic therapy was associated with improved 3-year overall survival among patients with advanced intrahepatic cholangiocarcinoma.

According to results from a...

01/19/2024

Oncology

Conference Coverage

Atezolizumab and Bevacizumab Plus Chemotherapy Provides Modest PFS Benefit in Advanced Biliary Tract Cancer

01/19/2024

Janelle Bradley

First-line treatment with atezolizumab and bevacizumab plus chemotherapy provides PFS advantage vs atezolizumab plus placebo and chemotherapy for patients with advanced biliary tract cancer, according to findings from the phase 2 IMbrave151...

First-line treatment with...

01/19/2024

Oncology

Recent News

FDA Approval

FDA Approves Zenocutuzumab for Patients With NRG1 Fusion-Positive Advanced Cholangiocarcinoma

05/08/2026

Stephanie Holland

Based on results from the phase 2 eNRGy trial, the FDA has approved zenocutuzumab for previously treated patients with advanced cholangiocarcinoma harboring NRG1 gene fusions.

Based on results from the phase...

05/08/2026

Oncology

News

Daraxonrasib Shows Clinical Promise in Patients With RAS-mutated Pancreatic Ductal Adenocarcinoma

05/07/2026

Stephanie Holland

Results from a phase 1/2 study demonstrated that the daraxonrasib showed clinical promise in previously treated patients with RAS-mutated pancreatic ductal adenocarcinoma.

Results from a phase 1/2 study...

05/07/2026

Oncology

FDA Approval

FDA Approves Extended-Release Ruxolitinib Across Hematologic Indications

05/07/2026

Stephanie Holland

Based on pharmacokinetic bioequivalence data, the FDA has approved extended-release ruxolitinib for patients with myelofibrosis, polycythemia vera, and graft-versus-host disease.

Based on pharmacokinetic...

05/07/2026

Oncology

FDA Alerts

Camizestrant Fails to Gain Support from the FDA’s Advisory Committee in ESR1-Mutated Advanced Breast Cancer

05/07/2026

Stephanie Holland

Based on results from the SERENA-6 trial, the FDA’s Oncologic Drugs Advisory Committee has voted that camizestrant plus CDK4/6 inhibition does not demonstrate a favorable benefit-risk profile in patients with HR-positive, HER2-negative...

Based on results from the...

05/07/2026

Oncology

News

Complete Consolidative Radiotherapy Improves Survival in Extensive-Stage Small Cell Lung Cancer

05/07/2026

Emily Estrada

Results from a retrospective cohort study demonstrated that completion of consolidative radiotherapy was associated with significantly improved survival outcomes in patients with extensive-stage small cell lung cancer.

Results from a retrospective...

05/07/2026

Oncology

News

Oligoprogression Predicts Improved Survival After Chemoimmunotherapy in Relapsed Small Cell Lung Cancer

05/07/2026

Emily Estrada

Results from a retrospective analysis demonstrated that patterns of post-chemoimmunotherapy progression were strongly associated with outcomes in relapsed small cell lung cancer.

Results from a retrospective...

05/07/2026

Oncology

News

Giredestrant Demonstrates Antiproliferative Activity in Premenopausal Patients With Early Breast Cancer

05/07/2026

Stephanie Holland

Results from the phase 2 PREcoopERA trial demonstrated that giredestrant shows antiproliferative activity in premenopausal ER-positive, HER2-negative early breast cancer.

Results from the phase 2...

05/07/2026

Oncology

News

Glecirasib-Based Regimens Show Promise in KRAS G12C-Mutant Metastatic Colorectal Cancer

05/07/2026

Emily Estrada

Combined results from the JAB-21822-1002 and JAB-21822-1007 trials demonstrate that glecirasib shows clinical promise both alone and in combination with cetuximab in KRAS G12C-mutated locally advanced or metastatic colorectal cancer.

Combined results from the...

05/07/2026

Oncology

News

ctDNA Dynamics to Predict Survival Outcomes in Patients With Metastatic Colorectal Cancer

05/07/2026

Emily Estrada

Exploratory ctDNA results from the phase 2 VALENTINO study demonstrated that baseline detection and early ctDNA dynamics are strongly associated with clinical outcomes in patients with metastatic colorectal cancer.

Exploratory ctDNA results from...

05/07/2026

Oncology

FDA Alerts

Capivasertib Gains Support from the FDA’s Advisory Committee in Metastatic Hormone-Sensitive Prostate Cancer

05/04/2026

Stephanie Holland

Based on results from the phase 3 CAPItello-281 trial, the FDA’s Oncologic Drugs Advisory Committee has voted that capivasertib plus abiraterone and ADT demonstrates a favorable benefit-risk profile in PTEN-deficient metastatic...

Based on results from the phase...

05/04/2026

Oncology