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News
Pirtobrutinib Plus Venetoclax and Obinutuzumab Produces Deep MRD Remissions in Treatment-Naïve Chronic Lymphocytic Leukemia
09/21/2026
Emily Estrada
Results from a phase 2 trial demonstrated that pirtobrutinib plus venetoclax and obinutuzumab produced deep measurable remissions in untreated patients with chronic lymphocytic leukemia, with responses largely maintained after treatment...
Results from a phase 2 trial demonstrated that pirtobrutinib plus venetoclax and obinutuzumab produced deep measurable remissions in untreated patients with chronic lymphocytic leukemia, with responses largely maintained after treatment...
Results from a phase 2 trial...
09/21/2026
Oncology
News
Fixed-Duration Pirtobrutinib Plus Venetoclax and Rituximab Emerges as Potential New Standard in Relapsed/Refractory Chronic Lymphocytic Leukemia
06/16/2026
Stephanie Holland
Results from the phase 3 BRUIN CLL-322 trial demonstrated that pirtobrutinib plus venetoclax and rituximab significantly improved outcomes compared with venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia.
Results from the phase 3 BRUIN CLL-322 trial demonstrated that pirtobrutinib plus venetoclax and rituximab significantly improved outcomes compared with venetoclax plus rituximab in relapsed or refractory chronic lymphocytic leukemia.
Results from the phase 3 BRUIN...
06/16/2026
Oncology
News
Bexobrutideg Continues to Demonstrate Clinical Promise Following BTK Inhibitor Resistance in Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
06/11/2026
Stephanie Holland
Updated results from a phase 1a/1b study show that bexobrutideg, a highly selective, oral BTK degrader, continues to demonstrate strong clinical promise among patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.  
Updated results from a phase 1a/1b study show that bexobrutideg, a highly selective, oral BTK degrader, continues to demonstrate strong clinical promise among patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.  
Updated results from a phase...
06/11/2026
Oncology
Richard Furman, MD
Videos
Immature Data Limit Conclusions on Continuous vs Fixed-Duration Frontline CLL Therapies
03/19/2026
Richard Furman, MD
Richard Furman, MD, discusses early results from the CLL-17 trial, underscoring the need for longer follow-up before defining optimal frontline strategies for treatment-naïve patients with chronic lymphocytic leukemia.
Richard Furman, MD, discusses early results from the CLL-17 trial, underscoring the need for longer follow-up before defining optimal frontline strategies for treatment-naïve patients with chronic lymphocytic leukemia.
Richard Furman, MD, discusses...
03/19/2026
Oncology
FDA Approval
FDA Approves Acalabrutinib Plus Venetoclax for Previously Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
02/20/2026
Emily Estrada
The FDA approved acalabrutinib plus venetoclax for previously untreated chronic lymphocytic leukemia and small lymphocytic lymphoma without del(17p) or TP53 mutations, based on the phase 3 AMPLIFY trial demonstrating significantly improved...
The FDA approved acalabrutinib plus venetoclax for previously untreated chronic lymphocytic leukemia and small lymphocytic lymphoma without del(17p) or TP53 mutations, based on the phase 3 AMPLIFY trial demonstrating significantly improved...
The FDA approved acalabrutinib...
02/20/2026
Oncology
Matthew Davids, MD
Videos
Genetic Risk Factors May Help Predict Richter Transformation in Chronic Lymphocytic Leukemia
01/05/2026
Matthew S. Davids, MD, MMSc
Matthew Davids, MD, highlights advances in identifying and managing Richter transformation among patients with chronic lymphocytic leukemia.
Matthew Davids, MD, highlights advances in identifying and managing Richter transformation among patients with chronic lymphocytic leukemia.
Matthew Davids, MD, highlights...
01/05/2026
Oncology
Wojciech Jurczak, MD, PhD
Conference Coverage
Frontline Pirtobrutinib Shows Superior PFS vs Bendamustine-Rituximab for CLL/SLL: BRUIN CLL-313 Trial
12/15/2025
Wojciech Jurczak, MD, PhD
According to first results from a phase 3 trial presented by Wojciech Jurczak, MD, PhD, at the 2025 ASH Annual Meeting, pirtobrutinib showed superior PFS and tolerability for treatment-naïve chronic lymphocytic leukemia/small lymphocytic...
According to first results from a phase 3 trial presented by Wojciech Jurczak, MD, PhD, at the 2025 ASH Annual Meeting, pirtobrutinib showed superior PFS and tolerability for treatment-naïve chronic lymphocytic leukemia/small lymphocytic...
According to first results from...
12/15/2025
Oncology
Catherine Coombs, MD
Conference Coverage
Evolving Treatment Strategies for Patients With Chronic Lymphocytic Leukemia
06/28/2025
Catherine Coombs, MD
At the 2025 Great Debates in Hematologic Malignancies meeting , Catherine Coombs, MD, discussed insights into evolving treatment strategies for patients with chronic lymphocytic leukemia.
At the 2025 Great Debates in Hematologic Malignancies meeting , Catherine Coombs, MD, discussed insights into evolving treatment strategies for patients with chronic lymphocytic leukemia.
At the 2025 Great Debates in...
06/28/2025
Oncology
Catherine Coombs, MD
Conference Coverage
Evolving Treatment Strategies for Patients With Chronic Lymphocytic Leukemia
06/28/2025
Catherine Coombs, MD
At the 2025 Great Debates in Hematologic Malignancies meeting , Catherine Coombs, MD, discussed insights into evolving treatment strategies for patients with chronic lymphocytic leukemia.
At the 2025 Great Debates in Hematologic Malignancies meeting , Catherine Coombs, MD, discussed insights into evolving treatment strategies for patients with chronic lymphocytic leukemia.
At the 2025 Great Debates in...
06/28/2025
Oncology
Constantine Tam, MD
Conference Coverage
Zanubrutinib for Patients With del(17p) CLL and SLL: 5-Year Follow-Up From the SEQUOIA Trial
06/03/2025
Constantine S. Tam
Constantine Tam, MD discusses 5-year follow-up results from the SEQUOIA trial evaluating the efficacy of zanubrutinib for patients with chronic lymphocytic leukemia and a chromosome 17p deletion.
Constantine Tam, MD discusses 5-year follow-up results from the SEQUOIA trial evaluating the efficacy of zanubrutinib for patients with chronic lymphocytic leukemia and a chromosome 17p deletion.
Constantine Tam, MD discusses...
06/03/2025
Oncology

Recent News

News
FDA Grants Fast Track Designation to LYT-200 Plus Hypomethylating Therapy for Relapsed or Refractory High-Risk Myelodysplastic Syndromes
09/22/2026
Emily Estrada
The FDA granted Fast Track designation to LYT-200 plus a hypomethylating agent for relapsed or refractory high-risk myelodysplastic syndromes following early-phase findings demonstrating clinical activity and supporting advancement of the...
The FDA granted Fast Track designation to LYT-200 plus a hypomethylating agent for relapsed or refractory high-risk myelodysplastic syndromes following early-phase findings demonstrating clinical activity and supporting advancement of the...
The FDA granted Fast Track...
09/22/2026
Oncology
News
Trastuzumab Deruxtecan Reduces Risk of Progression or Death in First-Line HER2-Mutant Non-Small Cell Lung Cancer
09/22/2026
Stephanie Holland
Results from the phase 3 DESTINY-Lung04 trial demonstrated that first-line trastuzumab deruxtecan significantly improved progression-free survival and response compared with pembrolizumab plus chemotherapy in advanced HER2-mutant non-small...
Results from the phase 3 DESTINY-Lung04 trial demonstrated that first-line trastuzumab deruxtecan significantly improved progression-free survival and response compared with pembrolizumab plus chemotherapy in advanced HER2-mutant non-small...
Results from the phase 3...
09/22/2026
Oncology
News
Tafasitamab Plus Lenalidomide and R-CHOP Significantly Improves PFS in High-Risk Diffuse Large B-Cell Lymphoma or High-Grade B-Cell Lymphoma
09/21/2026
Emily Estrada
Results from the phase 3 FrontMIND trial demonstrated that adding tafasitamab and lenalidomide to R-CHOP significantly improved progression-free survival in previously untreated patients with high-risk diffuse large B-cell lymphoma or...
Results from the phase 3 FrontMIND trial demonstrated that adding tafasitamab and lenalidomide to R-CHOP significantly improved progression-free survival in previously untreated patients with high-risk diffuse large B-cell lymphoma or...
Results from the phase 3...
09/21/2026
Oncology
FDA Approval
FDA Approves Imlunestrant Plus Abemaciclib for ESR1-Mutated Advanced Breast Cancer
09/18/2026
Stephanie Holland
Based on results from the phase 3 EMBER-3 trial, the FDA approved imlunestrant plus abemaciclib for previously treated ESR1-mutated, ER-positive, HER2-negative advanced or metastatic breast cancer, establishing a biomarker-selected...
Based on results from the phase 3 EMBER-3 trial, the FDA approved imlunestrant plus abemaciclib for previously treated ESR1-mutated, ER-positive, HER2-negative advanced or metastatic breast cancer, establishing a biomarker-selected...
Based on results from the phase...
09/18/2026
Oncology
FDA Alerts
FDA Approves Taletrectinib Label Update Reflecting Durable Responses in TKI-Naïve ROS1-Positive Non-Small Cell Lung Cancer
09/17/2026
Emily Estrada
The FDA approved a supplemental new drug application updating the taletrectinib label with longer-term TRUST-I data demonstrating sustained response durability in TKI-naïve advanced ROS1-positive non-small cell lung cancer, with no new safety...
The FDA approved a supplemental new drug application updating the taletrectinib label with longer-term TRUST-I data demonstrating sustained response durability in TKI-naïve advanced ROS1-positive non-small cell lung cancer, with no new safety...
The FDA approved a supplemental...
09/17/2026
Oncology
News
Epcoritamab Plus Lenalidomide and Rituximab Shows Superior Efficacy in Second-Line or Later Follicular Lymphoma
09/17/2026
Emily Estrada
Results from the phase 3 EPCORE FL-1 trial demonstrated that adding epcoritamab to lenalidomide plus rituximab significantly improved response, depth of response, and progression-free survival in patients with relapsed or refractory...
Results from the phase 3 EPCORE FL-1 trial demonstrated that adding epcoritamab to lenalidomide plus rituximab significantly improved response, depth of response, and progression-free survival in patients with relapsed or refractory...
Results from the phase 3 EPCORE...
09/17/2026
Oncology
News
Low-Dose Ruxolitinib Significantly Reduces Acute Graft-Versus-Host Disease After Haploidentical Transplantation
09/17/2026
Emily Estrada
Results from a phase 3 trial demonstrated that replacing mycophenolate mofetil with low-dose ruxolitinib significantly reduced acute graft-versus-host disease following haploidentical hematopoietic stem-cell transplantation, supporting...
Results from a phase 3 trial demonstrated that replacing mycophenolate mofetil with low-dose ruxolitinib significantly reduced acute graft-versus-host disease following haploidentical hematopoietic stem-cell transplantation, supporting...
Results from a phase 3 trial...
09/17/2026
Oncology
News
Sacituzumab Govitecan Plus Pembrolizumab Fails to Significantly Improve PFS in PD-L1–High Metastatic Non-Small Cell Lung Cancer
09/16/2026
Stephanie Holland
Results from the phase 3 EVOKE-03 trial demonstrated that adding sacituzumab govitecan to pembrolizumab did not significantly improve progression-free or overall survival in untreated patients with PD-L1–high metastatic non-small cell lung...
Results from the phase 3 EVOKE-03 trial demonstrated that adding sacituzumab govitecan to pembrolizumab did not significantly improve progression-free or overall survival in untreated patients with PD-L1–high metastatic non-small cell lung...
Results from the phase 3...
09/16/2026
Oncology
FDA Alerts
FDA Label Update Shortens Initial Tarlatamab Monitoring to Support Broader Extensive-Stage Small Cell Lung Cancer Treatment Access
09/16/2026
Stephanie Holland
The FDA updated the prescribing information for tarlatamab to substantially shorten monitoring following the first 2 doses in patients with extensive-stage small cell lung cancer, potentially reducing treatment burden and facilitating...
The FDA updated the prescribing information for tarlatamab to substantially shorten monitoring following the first 2 doses in patients with extensive-stage small cell lung cancer, potentially reducing treatment burden and facilitating...
The FDA updated the prescribing...
09/16/2026
Oncology
News
Tarlatamab Plus Durvalumab Improves Survival as First-Line Maintenance Therapy in Extensive-Stage Small Cell Lung Cancer
09/15/2026
Emily Estrada
Topline results from the phase 3 DeLLphi-305 trial showed that adding tarlatamab to durvalumab significantly improved overall and progression-free survival compared with durvalumab alone as first-line maintenance therapy for patients with...
Topline results from the phase 3 DeLLphi-305 trial showed that adding tarlatamab to durvalumab significantly improved overall and progression-free survival compared with durvalumab alone as first-line maintenance therapy for patients with...
Topline results from the phase 3...
09/15/2026
Oncology

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